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Background: To identify apolipoprotein E (APOE)-specific factors that may predict life expectancy after a diagnosis of Alzheimer’s disease (AD). Method: The Swedish Alzheimer Treatment Study (SATS) is a prospective, observational, clinical-practice-based, multicentre study that includes 999 participants diagnosed with mild-to-moderate AD at the start of cholinesterase inhibitor (ChEI) therapy (tim

In this volume of “Lecture Notes in Intelligent Transportation and Infrastructure”, we are pleased to present the proceedings of the International Conference “Vision Zero for Sustainable Road Safety in Baltic Sea Region”, which took place in Vilnius, Lithuania, from 5 to 6 December 2018. This event is organized by Vilnius Gediminas Technical University (VGTU) and Lithuanian-Swedish Academy. The miIn this volume of “Lecture Notes in Intelligent Transportation and Infrastructure”, the proceedings of the International Conference “Vision Zero for Sustainable Road Safety in Baltic Sea Region”, which took place in Vilnius, Lithuania, from 5 to 6 December 2018, are presented. The mission of the conference was to promote a more comprehensive approach supporting new ideas, technologies, theories, i

Abstract. Objectives. To ascertain whether a relationship exists between the PiZ alpha1‐antitrypsin (α1AT) variant and antineutrophil cytoplasm antibodies (ANCA)‐positive vasculitis in a large group of Swedish patients, and whether analysis for the presence of the PiZ variant might be useful for diagnostic or prognostic purposes. Design. Retrospective cross‐sectional study. Setting. The Department

We describe the clinical presentation and outcome in a series of eight patients with systemic necrotizing vasculitis and severe alpha1-antitrypsin (AAT) deficiency followed up at three Swedish hospitals during 1968-92. We also review six other cases reported in the literature during the same period. Diagnosis of severe AAT deficiency was based on the presence of the PiZZ phenotype, or low plasma t

OBJECTIVE The authors aimed to develop the first clinical grading scale for patients with surgically treated spontaneous supratentorial intracerebral hemorrhage (ICH). METHODS A nationwide multicenter study including 401 ICH patients surgically treated by craniotomy and evacuation of a spontaneous supratentorial ICH was conducted between January 1, 2011, and December 31, 2015. All neurosurgical ce

Abstract OBJECTIVES: To evaluate the influence of age on survival and risk of subsequent fracture in men with hip fracture, applying a residual lifetime perspective. DESIGN: Retrospective cohort study with 22-year follow-up. SETTING: Skåne University Hospital, Malmö, Sweden. PARTICIPANTS: Men aged 60 and older (N=226) with an index hip fracture during 1984/85. MEASUREMENTS: Twenty-two-year sur

PURPOSE: This study was designed to assess aorto-iliac morphological characteristics in relation to reintervention and all-cause long-term mortality in patients undergoing standard EVAR for infrarenal AAA. METHODS: Patients treated with EVAR (Zenith(®) Stentgrafts, Cook) between May 1998 and February 2006 were prospectively enrolled in a computerized database where comorbidities and preoperative

There is little epidemiological data on heart failure (HF) in the younger age groups dominating clinical HF trials. We assessed gender-specific long-term HF incidence and mortality in an urban community-based sample of middle-aged subjects. Between 1974 and 1992, 33,342 HF-free subjects (10,900 [32.7%] women, mean age 45.7 +/- 7.4 years) were included in the Malmö Preventive Project, on average 21

Background: In order to increase treatment coverage, antiretroviral treatment (ART) is provided through primary health care in low-income high-burden countries, where tuberculosis (TB) co-infection is common. We investigated the long-term outcome of health center-based ART, with regard to concomitant TB.Methods: ART-naïve adults were included in a prospective cohort at Ethiopian health centers and

Objectives We investigated gender differences in the association between mortality and general psychological distress (measured by 12-item General Health Questionnaire, GHQ-12), as an increased mortality risk has been shown in community studies, but gender differences are largely unknown. Setting We used data from a cross-sectional population-based public health survey conducted in 2008 in the Swe

OBJECTIVE: Previous literature has suggested that identifying putative differences in health care seeking patterns before death by suicide depending on age and gender may facilitate more targeted suicide preventive approaches. The aim of this study is to map health care utilisation among individuals in the two years prior to suicide in Sweden in 2015 and to examine possible age and gender differen

OBJECTIVE To estimate the risk of all cause and cause specific mortality in people with obsessive-compulsive disorder (OCD) compared with matched unaffected people from the general population and with their unaffected siblings. DESIGN Population based matched cohort and sibling cohort study. SETTING Register linkage in Sweden. PARTICIPANTS Population based cohort including 61 378 people with OCD a

Context: Clinically assisted hydration during end-of-life care among patients with cancer is controversial; practice varies between clinical settings and countries, and there is a lack of evidence. Objectives: To examine whether breathlessness, respiratory secretion, or confusion correlates with receiving parenteral hydration during end of life, adjusted for sex, age, and place of death. Methods:

BACKGROUND: Despite pain control being a top priority in end-of-life care, pain continues to be a troublesome symptom and comprehensive data on pain prevalence and pain relief in patients with different diagnoses are scarce.METHODS: The Swedish Register of Palliative Care (SRPC) was used to retrieve data from 2011 to 2022 about pain during the last week of life. Data were collected regarding occur

Long-term oxygen therapy (LTOT) ≥ 15 h/day improves survival in hypoxemic chronic obstructive pulmonary disease (COPD). LTOT 24 h/day is often recommended but may pose an unnecessary burden with no clear survival benefit compared with LTOT 15 h/day. The aim was to test the hypothesis that LTOT 24 h/day decreases all-cause, respiratory, and cardiovascular mortality compared to LTOT 15 h/day in hypo

Omkring en tredjedel av alla sammanlevande par i Sverige idag är sambor och omfattas därigenom av sambolagen. Sambolagens huvudsyfte är att tillhandahålla ett minimiskydd till den svagare parten när samboförhållandet upplöses. I och med att samboförhållandena ökar i antal varar allt fler samboförhållanden längre, till och med livet ut. Mot bakgrund av detta är uppsatsens mål att behandla vilket efAbout one third of all couples in Sweden today are cohabitants and therefore subject to the Cohabitees Act. The purpose of the Cohabitees Act is to provide minimum protection for the weaker party when a cohabitee relationship ends. Due to the fact that cohabitee relationships are increasing in number, more cohabitee relationships are lasting longer, some even for life. Considering this, the object

De kallas ”evighetskemikalier” Det började med att öka flygsäkerheten på Arlanda men har idag lett till en miljömässig påverkan. De så kallade evighetskemikalierna, PFAS, sprider sig i marken och grundvattnet vid Sveriges största flygplats. Men vad är det egentligen som sker under markytan som inte syns med blotta ögat? PFAS är kemikalier som är stabila och mycket svårnedbrytbara i naturen. Det mPFAS contamination has been identified at numerous sites worldwide, particularly at firefigh-ting training facilities. Firefighting foams, Aqueous film forming foam (AFFF), used at these facilities often contain PFAS as their active substance. The aim of this study was to examine factors that influence transport of eleven different substances of PFAS. Furthermore the study aimed to see how long ti

BACKGROUND: Children, adolescents, and young adults with cancer (referred to as CAYAs) are at risk of long-term health complications, with cardiovascular disease (CVD) being a major concern. In addition, sociodemographic characteristics and traditional cardiovascular risk factors may also contribute to disparities in outcomes compared with those of the general population. The aim of this study was

Objective: Although rare, malignant ovarian germ cell tumors (MOGCTs) account for 70 % of ovarian malignancies in women younger than 30 years. Given the rarity of MOGCTs and the limited population-based data, this study aims to examine national treatment patterns and survival in women with MOGCTs, with a focus on fertility-sparing surgery. Methods: This nationwide population-based study included a