Filetype
Objective:To compare the diagnostic accuracy of CSF biomarkers and amyloid PET for diagnosing early-stage Alzheimer disease (AD).Methods:From the prospective, longitudinal BioFINDER study, we included 122 healthy elderly and 34 patients with mild cognitive impairment who developed AD dementia within 3 years (MCI-AD). -Amyloid (A) deposition in 9 brain regions was examined with [F-18]-flutemetamol
Type 2 diabetes (T2D) is a disease characterised by varying degrees of defect in insulin secretion and insulin sensitivity and associated with increased morbidity and mortality. Optimal glycaemic control reduces the progression of diabetic complications. Over time, there is a steady deterioration of glycaemic control that raises the need for effective therapy targeted at the underlying defects in
Popular Abstract in Swedish I detta arbete studerades olika aspekter av lapptestdiagnostiken vid misstänkt kontaktallergi mot en grupp ämnen som kallas isocyanater. Dessa ämnen innehåller reaktiva isocyanatgrupper med den kemiska strukturen -N=C=O. Isocyanater används framförallt vid tillverkningen av polyuretan (PUR) som bildas när iso-cyanater reagerar med flerfunktionella alkoholer till en polyIsocyanates are highly reactive compounds used in the production of polyurethane. Exposure to isocyanates is mainly associated with respiratory disorders, but may also result in allergic contact dermatitis. Reports describing contact allergy to isocyanates are few in number and it has been considered a rare phenomenon. In the present study it is shown that the low frequency of reported cases could
Popular Abstract in Swedish Hur kommer det sig att liknande reformprogram återfinns i olika länder? Varför väljs vissa idéer framför andra? Avhandlingen syftar till att öka förståelsen av så kallad policydiffusion, spridning av olika typer av policy, och den dynamik som omgärdar spridningen. Detta görs genom att undersöka hur externa, eller utländska, idéer integreras och översätts i en ny omgivniSimilar policies may be found in different countries. This, in turn, is an indication that policies travel. But why are certain policies imitated while others are not? The author seeks to further our understanding of policy diffusion and its dynamics by investigating how foreign ideas are integrated and translated into new contexts, and how these imported ideas influence national policymaking and
Two different chemical recipes comprising various pollutants were selected to create high (HC) and low (LC) levels of contaminated synthetic greywaters (SGW). Remediation in macrocosm–scale floating treatment wetlands (FTW) vegetated with Phragmites australis (Cav.) Trin. ex Steud. (common reed) was investigated under natural weather conditions. The presence or absence of vegetation, short or long
This thesis investigates the interface between external impressions of an organization, often referred to as its brand and image, and internal expressions, its culture and the identity of its employees, in organizations that have suffered crises of confidence. More specifically, the thesis seeks to problematize the alignment ideal in the corporate branding perspective (de Chernatony, 2001; Harris
The general aim of the research presented in this thesis was to contribute to the understanding of how breast cancer patients with germline BRCA1/2 mutations should be treated medically and surgically, and furthermore, to characterize the limitations and strengths of different procedures for BRCA testing. In Paper I, the long-term prognosis was assessed in a cohort of early-onset breast cancer pat
INTRODUCTION: Treatment response in high grade gliomas (HGG) is influenced by O6-methylguanine-DNA methyltransferase promoter methylation (MGMTpm). Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) is a non-invasive approach for potential molecular tumor characterization, although previous studies have reported inconsistent results for MGMTpm. This study investigates fl
Problem area Alfa Laval is a world leading company in the heat transfers area and have the vision to continue to be that in the future as well. The company has a lot of press lines where the utilization is high and also has started to become old. Prognosis shows that there is an increased demand of heat exchanger in the future. This increased demand is not something that existing lines will manag
Populärvetenskaplig sammanfattning: Vår jordskorpa är uppbyggd av ett antal kontinentplattor som under hela jordens existens rört sig relativt varandra. Således har en och samma kontinentplatta vid upprepade tillfällen kolliderat med andra plattor under uppbyggnad av mäktiga bergskedjor - vid andra tillfällen har de splittrats upp i mindre kontinenter. Bergarter nära plattkanterna kommer vid dessaThe Protogine Zone is the easternmost major deformation zone in the southern part of the Sveconorwegian Province. Over the past 20 years discussions have concerned its tectonic significance, e.g. whether this zone is extensional or compressional. Several generations of mafic intrusives are situated along the Protogine Zone. The metamorphic and deformational history of these intrusions provides a k
Uppsatsens fokus ligger på att undersöka effekterna av det 21 december 2012 ikraftträdda förbudet mot könsdifferentierade försäkringspremier och –ersättningar. Förbudet har sin bakgrund i ett mål i EU-domstolen, där domstolen kom att ogiltigförklara en undantagsregel som gav medlemsstaterna möjlighet att på obestämd tid tillåta användandet av kön som faktor vid försäkringsföretagens beräknande av The main purpose of this thesis is to evaluate and analyze the impact of the prohibition against the use of sex as a factor in the calculation of premiums and benefits for the purpose of insurance services that entered into force 21 December 2012. The prohibition is a result of a judgment by the European Court of Justice declaring that the exception in Directive 2004/113/EC, giving member states t
A Linear e+e- collider, either ILC or CLIC will be the next platform for high energy physics study to complement the LHC. Results discovered by LHC may need precision measurements before we can get full understanding of the physics. International collaborations are in the process to prepare both for the accelerator and for the experimental setup. Time projection chambers as the main central track
Hope was founded in 2001 by Ann Ringstrand and Stefan Söderberg. Since then the company has grown rapidly. It has won many prestigious design awards and is considered one of the most promising Swedish fashion companies. To gain control of their expansion they needed a sales forecasting tool. The search for a suitable method started with Hope’s sales order history. Due to very short and irregular r
Alla företag, stater, myndigheter och organisationer är i behov av att kunna locka till sig extra kapital till att användas för att finansiera olika verksamheter. Det finns ett flertal olika metoder för detta ändamål såsom banklån, obligationslån, strukturerade produkter, eller utgivning av nya aktier. Uppsättningen av finansieringsmetoder som används av ett företag kallas företagets kapitalstruAll companies, governments, states and organisations need to raise additional finance for different purposes. There are several different methods, such as bank loans, bonds, notes, structured products or new equity, available to obtain the required amount of money. The set of financial sources used by a corporate entity is called the company´s capital structure. Commonly, a company uses a number
Boreal forests mitigate climate change by sequestering atmospheric carbon. Recent declines in the boreal carbon sink and tree growth suggest that this mitigating influence is weakening, yet the underlying drivers remain unresolved. Increasing drought frequency is one likely driver. Yet most studies have focused on managed forests, overlooking the significant but shrinking areas of old-growth fores
Introduction: After resuscitation from out of hospital cardiac arrest (OHCA), mechanical ventilation (MV) and respiratory management are fundamental to support patients in the intensive care unit (ICU) and to minimise secondary brain injury. Best practices for MV and association with clinical outcomes in patients with OHCA remain unclear. Methods and analysis: This protocol describes a pre-planned
Background: Radiographic damage in rheumatoid arthritis (RA) includes erosions and joint space narrowing (JSN). Different mechanisms may underlie their development. The objective of this study was to evaluate predictors of these entities separately. Methods: Consecutive early RA patients (symptom duration ≤12 months) from a defined area (Malmö, Sweden) recruited during 1995-2005 were investigated
The treatment of glaucoma is focused on reducing the intraocular pressure to a level at which progression is impeded. A diagnosis of glaucoma is not considered certain until progression is confirmed, and thus detecting progression is a central aspect in both the diagnosing and the monitoring of glaucoma patients. Progression can be identified either through examination of either functional changes
Background The coverage of prevention and treatment strategies for ischemic heart disease and stroke is very low in Ethiopia. In view of Ethiopia’s meager healthcare budget, it is important to identify the most cost-effective interventions for further scale-up. This paper’s objective is to assess cost-effectiveness of prevention and treatment of ischemic heart disease (IHD) and stroke in an Ethiop
Protein-protein interactions are crucial in numerous cellular functions and biological processes that take place inside our body. It is therefore not surprising that these interactions also govern the response of our body´s defence mechanism, the so-called immune system, towards an infection. Understanding how proteins interact entails studying the binding affinity (strength) and the lifetime (dur
