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All cells of the musculoskeletal system possess transmembrane syndecan proteoglycans, notably syndecan-4. In fibroblasts it regulates integrin-mediated adhesion to the extracellular matrix. Syndecan-4 null mice have a complex wound repair phenotype while their fibroblasts have reduced focal adhesions and matrix contraction abilities. Signalling through syndecan-4 core protein to the actin cytoskel
Background: Cystatin C may add explanatory power for associations with mortality in combination with other filtration markers, possibly indicating pathways other than glomerular filtration rate (GFR). However, this has not been firmly established since interpretation of associations independent of measured GFR (mGFR) is limited by potential multicollinearity between markers of GFR. The primary aim
SPRINT (Systolic Blood Pressure Intervention Trial) showed that intensive lowering of systolic blood pressure to <120 mm Hg was beneficial, as compared with standard treatment in which systolic blood pressure is lowered to <140 mm Hg. The proposal that the results of SPRINT were mainly driven by the reduction of heart failure events has undermined the main conclusion of the study. Therefore, this
BackgroundChildren and adolescents treated for a brain tumor suffer from more fatigue than survivors of other types of childhood cancer. As tumor location might be predictive of fatigue, our aim was to investigate the longitudinal development of fatigue in children with brain tumors and risk factors for fatigue separately for different tumor locations.MethodsFatigue was assessed 1235 times for 425
The diagnosis of lymphoma relies mainly on clinical examination and laboratory explorations. Among the latter, morphological and immunohistochemical analysis of a tissue biopsy are the cornerstones for proper identification and classification of the disease. In lymphoma with blood and/or bone marrow involvement, multiparameter flow cytometry is useful. This technique can also be applied to fresh c
Infectious and parasitic agents (IPAs) and their associated diseases are major environmental stressors that jeopardize bee health, both alone and in interaction with other stressors. Their impact on pollinator communities can be assessed by studying multiple sentinel bee species. Here, we analysed the field exposure of three sentinel managed bee species (Apis mellifera, Bombus terrestris and Osmia
Introduction: Children born preterm are at increased risk for adverse neurodevelopmental outcomes. Music and reading activities in childhood could ameliorate these difficulties, as they have shown benefits on both neural and behavioral levels. However, only a few studies have assessed these potential benefits in preterm-born children. We investigated whether music and language activities in early
Deep neural networks tend to be vulnerable to adversarial perturbations, which by adding to a natural image can fool a respective model with high confidence. Recently, the existence of image-agnostic perturbations, also known as universal adversarial perturbations (UAPs), were discovered. However, existing UAPs still lack a sufficiently high fooling rate, when being applied to an unknown target mo
Trusted Third Parties (TTPs) are a standard building block in secure systems and are used in many cryptographic protocols. A TTP is an entity which facilitates interaction between the users in a system. As the name suggests, TTPs are trusted, and can thus be relied on to perform critical parts of a protocol without need for external scrutiny. Due to this property, they can serve the role of making
Generative AI tools (GenAI) are increasingly used for academic tasks, including qualitative data analysis for the Scholarship of Teaching and Learning (SoTL). In our practice as academic developers, we are frequently asked for advice on whether this use for GenAI is reliable, valid, and ethical. Since this is a new field, we have not been able to answer this confidently based on published literatu
BackgroundTo enable people with stroke to achieve an active everyday life under altered conditions, the development of self-management programs is essential to facilitate the process of change that individuals must undergo. To improve access to self-management, internet-based solutions have been proposed. The aim of this study was to evaluate the feasibility of a novel internet-based intervention,
Insect pollination, and in particular pollination by bees, is a highly valued ecosystem service that ensures plant reproduction and the production of high-quality crops. Bee activity is known to be influenced by the weather, and as the global climate continues to change, the flying frequency and foraging behaviour of bees may also change. To maximise the benefits of pollination in a changing world
Several studies have evaluated various ML techniques and found promising results in classifying bug reports. However, these studies have used different evaluation designs, making it difficult to compare their results. Furthermore, they have focused primarily on accuracy and did not consider other potentially relevant factors such as generalizability, explainability, and maintenance cost. These two
Background: Lung injury in COVID-19 is characterized by neutrophil invasion and the release of neutrophil extracellular traps (NETs). An aberrant NET formation may induce local inflammation and increase sputum viscosity. Inhalation of DNase I (dornase alfa) is a treatment option that degrades NETs in the airways. Previous case series have indicated positive clinical effects of inhaled dornase alfa
We investigated the mRNA expression of G protein-coupled receptors (GPCRs) in cells from four human vascular beds: umbilical vein (HUVEC), microvasculature (MVEC), aorta (HAEC), and coronary artery (CAEC). Our study revealed that the orphan receptor ELTD1 (ADGRL4) was the most abundantly expressed GPCR mRNA in all four EC types. When recombinantly expressed in U87 cells, ELTD1 receptors activated
In modern industrial settings with small batch sizes it should be easy to set up a robot system for a new task. Strategies exist, e.g. the use of skills, but when it comes to handling forces and torques, these systems often fall short. We introduce an approach that provides a combination of task-level planning with targeted learning of scenario-specific parameters for skill-based systems. We propo
A considerable number of lakes in Sweden have high phosphorus internal loading from the sediments which cause cyanobacterial blooms every summer. Due to potential risks with such blooms for human health, drinking water supply, and ecosystem services, measures need to be taken to control the phosphorus content. Measures to control the phosphorus input from the surrounding land has been in focus. Ho
OBJECTIVES: To study the effects on the number of laboratory tests ordered after introduction of cost display (showing the cost in the computerized test ordering system at test ordering and test result delivery) and cost charge (requiring all primary healthcare centers to pay full laboratory costs of the ordered tests). STUDY DESIGN: The study included cost display for secondary healthcare centers
Building resilient and sustainable energy systems is a critical challenge for disaster-prone regions in the Global South. This study investigates the energy management of a networked microgrid (NMG) system on Lombok Island, Indonesia, a region frequently exposed to natural disasters (NDs) and characterized by vulnerable grid infrastructure. A multi-objective optimization framework is developed to
Decoupling key intermediates’ adsorption via asymmetric 3d-5d-orbital hybridization overcomes the intrinsic scaling relation bottleneck, enabling rational design of high-performance, durable multifunctional electrocatalysts for anion exchange membrane water electrolyzers (AEMWEs) and Zn–air batteries (ZABs). Here, we reveal that asymmetric 3d-5d-orbital hybridization, engineered through the synerg
