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OBJECTIVES: Patients with chronic obstructive pulmonary disease (COPD) who also have acute coronary syndromes are a high-risk population with a high mortality rate. Little is known about these patients following coronary artery bypass grafting (CABG). METHODS: Patients presenting with acute coronary syndromes between 2006 and 2014 with an angiogram showing 3-vessel disease or left main coronary ar
UNLABELLED: The VDR is a candidate gene for osteoporosis. Here we studied five common polymorphisms of VDR in relation to calcium intake and vitamin D status in a population-based cohort of 3100 British women, but found no significant association with bone mass, bone loss, or fracture.INTRODUCTION: Population studies of vitamin D receptor (VDR) polymorphisms have produced conflicting results. We p
The interaction EPR split signals from photosystem II (PSII) have been reported from the S0, S1, and S3 states. The signals are induced by illumination at cryogenic temperatures and are proposed to reflect the magnetic interaction between YZ• and the Mn 4Ca cluster. We have investigated the formation spectra of these split EPR signals induced in PSII enriched membranes at 5 K using monochromatic l
Background: Abdominal aortic aneurysm is associated with an increased mortality, mostly cardiovascular events. Moreover, aortoiliac calcification is associated with increased mortality in patients with peripheral occlusive disease. The aim of this study is to assess the potential association between iliofemoral calcification, assessed by calcium score, in patients undergoing infrarenal (endovascul
Extracellular field potentials in the lumbosacral dorsal horn evoked by stimulation of cutaneous C fibres in the sural nerve were explored in the halothane‐anaesthetized rat. C‐fibre‐evoked field potentials were prominent in lamina II and lamina V of the dorsal horn. These potentials had a latency of 80‐130 ms and a duration of more than 200 ms. A peak in the C‐fibre‐evoked field potential, termed
We discovered structurally novel human calcium-sensing receptor (CaSR) allosteric agonists and compared their pharmacology to phenylalkylamine calcimimetics. 1-Benzothiazol-2-yl-1-(2,4-dimethyl-phenyl)-ethanol (AC-265347) activated CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays with potencies of 30 and 10 nM, respectively. (S)-1-Benzothiazol-2-yl-1-(2,4-di
An extended version of a numerical model introduced by Larson et al. (2013) to simulate long-term cross shore material exchange for the subaqueous portion of the profile has been developed. Efforts have focused on improving the model to better account for beach systems consisting of two bars (inner and outer bar), as well as simulating the feeder response over time of nearshore dredged material ba
The Aim of this research is to analyze how the socio-demographic characteristics of users of Complementary and Alternative Medicine (CAM) in Serbia influence and impact their consumption of OTC drugs. Respondents and methods: The study employed the third edition of the National Health Survey of the Republic of Serbia, published in 2013, as a data source covering the Serbian population. The sample
OBJECTIVE: To investigate the effect of the epidermal growth factor receptor (EGFR) on the induction of apoptosis by the chemotherapeutic agent etoposide (VP16), and to examine the effect of combining VP16 with gefitinib to see if the cell-survival mechanism can be prevented.MATERIALS AND METHODS: The bladder cancer cell lines RT4 and T24, representing low- and high-malignancy grades respectively,
Objective/background: Mycotic aortic aneurysms are rare, life threatening, and complex. This nationwide study aimed to assess outcome after repair of mycotic thoracic aortic aneurysms (MTAAs). Methods: Patients treated in Sweden for MTAAs between 2000 and 2016 were identified in the Swedish vascular registry (2010–16) and local patient registries (2000–09). Primary outcome was survival, and second
Atmospheric particulate matter and dust from agricultural land significantly affect air quality and human health in nearby residential areas. To quantify these air pollutants, it is important to estimate the vertical atmospheric particulate matter PM2.5, PM10, and dust flux using observations and validated models. To the authors´ knowledge, this has previously not been performed for semi-humid agr
Background: Plasma biomarkers may be useful to detect healthy individuals at increased risk for atherosclerotic manifestations, such as carotid artery stenosis. The aim of this longitudinal cohort study was to evaluate new biomarkers in relation to C-reactive protein and conventional risk factors for carotid artery stenosis during long term follow-up Methods: The following markers were measured in
Background and aims: Genetic loci associated with CHD show different relationships with intima-media thickness in the common carotid artery (IMT-CCA) and in the bulb (IMT-bulb). We evaluated if IMT-CCA and IMT-bulb differ also with respect to circulating protein profiles and risk of incident atherosclerotic disease. Methods: In three Swedish cohorts (MDC, IMPROVE, PIVUS, total n > 7000), IMT-CCA a
The incidence of fragility fractures is expected to increase in the near future due to an aging population. Therefore, improved tools for fracture prediction are required to treat and prevent these injuries efficiently. For such tools to succeed, a better understanding of the deformation mechanisms in bone over different length scales is needed. In this study, an experimental setup including mecha
Due to their unique physical and material properties, III-Sb nanowires are considered good candidates for future devices, and test beds for understanding fundamental physics. Synthesizing these nanowires however is associated with certain challenging aspects, which are generally not present for other III-V nanowires, demanding the need for in depth investigations. For instance, growing Au-seeded I
Chromatography is an important separation process for several industries due to its ability to separate components with similar physical properties, which are difficult to separate otherwise. This method may also give high product purity, which is necessary for production of biopharmaceuticals and fine chemicals. However, conventional feedback control systems cannot be utilized to control most chr
Increased awareness, interest and use of assistive technology (AT) presents substantial opportunities for many citizens to become, or continue being, meaningful participants in society. However, there is a significant shortfall between the need for and provision of AT, and this is patterned by a range of social, demographic and structural factors. To seize the opportunity that assistive technology
Background: Increased blood pressure is the biggest contributor to the global burden of disease and mortality. Data suggest that less than half of the population with hypertension is aware of it. May Measurement Month was initiated to raise awareness of the importance of blood pressure and as a pragmatic interim solution to the shortfall in screening programmes. Methods: This cross-sectional surve
Background: People with disabilities have the right to personal mobility and available and affordable assistive technology, according to the Convention of Rights of Persons with Disabilities. The aims were to investigate similarities and differences between Sierra Leone and Malawi concerning participants’ mobility and satisfaction with their lower-limb prosthetic or orthotic device and related ser
Abstract in UndeterminedIn the humanitarian context, gender mediates access to aid. The gender of the beneficiary is not only intrinsically linked with her/his disaster vulnerability (Enarson, 2002), but also to their ability to physically access aid distribution points (Lutz and Gady, 2004) and even to be considered a beneficiary in the first place. There is, however, yet another factor mitigatin
