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There is an increasing use of distributed computer systems to provide services in both traditional telephony as well as in the Internet. Two main technologies are Distributed Object Computing (DOC) and Web based services. One common DOC architecture investigated in this thesis is the Common Object Request Broker Architecture (CORBA), specified by the Object Management Group. CORBA applications con
AIMS: To investigate the disease causing event in patients with familial hypercholesterolaemia, carrying two mutations each, E256K in exon 6 and I402T in exon 9, of the gene encoding the low density lipoprotein (LDL) receptor. It was not known whether the mutations were positioned in cis or trans, or if they were each pathogenic separately or only when present together. METHODS: Polymerase chain r
The neuropathological substrate of dementia in patients with Parkinson's disease is still under debate, particularly in patients with insufficient alternate neuropathology for other degenerative dementias. In patients with pure Lewy body Parkinson's disease, previous post-mortem studies have shown that dopaminergic and cholinergic regulatory projection systems degenerate, but the exact pathways th
Popular Abstract in Swedish Järn har den kemiska beteckningen Fe från latinskans ferrum. Det är det fjärde vanligaste ämnet i världen och utgör ca en femtedel av jordskorpan. Trots det kan både djur och växter ha järnbrist. Hur kan detta vara möjligt? Problemet är egentligen inte förekomsten av järn utan att järnet som vi och alla andra organismer behöver har oxidationstillståndet Fe(II) medan detIt is of vital importance to understand the systems for iron metabolism and this thesis contributes to this by providing insights into the structure and function of the acquisition and homeostasis of iron. The two proteins that have been primarily investigated are a ferric reductase from Arabidopsis thaliana called FRO2 and a mitochondrial iron chaperone from Saccharomyces cerevisiae called fratax
The objectives of this dissertation are 1) to describe what child protection services actually do when assessing risk and deciding on interventions, and 2) to analyze this practice in the light of institutional expectations, organizational demands and professional technology. The field work was carried out in two Danish municipal social service agencies. Data consist of records on families subject
The overall aim of this work was to increase our knowledge of newborn infants and their mothers, gain a better understanding of attachment and the infants' development and identify infants at risk for poorer emotional, social and cognitive development. An interdisciplinary approach was used. Six studies are included in the thesis. Non-nutritive sucking (NNS) and its relation to neurobehavioural st
Popular Abstract in Swedish Proteiners interaktioner med andra proteiner, med polymerer och med ytor har stor praktisk betydelse inom bland annat proteinrening, läkemedelsformulering och livsmedelsteknologi. Målet med detta arbete är att öka förståelsen för växelverkan mellan proteiner, mellan proteiner och polymerer samt mellan proteiner och ytor, särskilt beträffande de elektrostatiska krafternaInteractions of proteins with other proteins, with polymers and with surfaces are of great practical importance within for instance protein purification, drug delivery, and food technology. The aim of this work is to increase the understanding of protein-protein, protein-polyelectrolyte, and protein-surface interactions, particularly concerning the role of electrostatic interactions in these syste
Om platser verkligen är av betydelse, vilket ekonomiska geografer anser, då måste de vara som mest betydelsefulla för de människor vars liv utspelar sig på dessa platser, och upplever världen, materiellt kan kulturellt, genom den. När en kris och efterföljande osäkerheter drabbar en plats så påverkar detta främst människorna som kallar denna platsen för sitt hem. Ibland till den grad att en del avIf places indeed matter, as economic geographers believe, then it must matter most to the people who live their everyday lives in these places and experience the world materially and socially through it. When a crisis hits and uncertainty ensues, it affects people who call these places home the most. So much so, that some of them might be willing to stake a claim on its recovery, and development t
Activity-related breathlessness is the most problematic symptom of chronic obstructive pulmonary disease (COPD), arising from complex interactions between periph- eral pathophysiology (both pulmonary and non-pulmonary) and central perceptual proces- sing. To capture information on the breathlessness experienced by people with COPD, many different instruments exist, which vary in applicability depe
Objectives: To assess whether vessel morphology depicted by three-dimensional (3D) power Doppler ultrasound improves discrimination between benignity and malignancy if used as a second-stage test in adnexal masses that are difficult to classify. Methods: This was a prospective observational international multicenter diagnostic accuracy study. Consecutive patients with an adnexal mass underwent sta
Kommersiella parter väljer idag i allt högre grad att slita sina tvister genom skiljeförfarande istället för att genomgå ett traditionellt domstolsförfarande. Skiljeförfarande är i grunden ett eninstansförfarande där parterna genom avtal avsäger rätten att på materiell grund överklaga skiljedomen. Detta medför emellertid inte att parterna avsagt sig rätten till ett processuellt korrekt förfarande.Today, commercial parties are more likely to choose arbitration as a means of solving their indifferences rather than traditional court proceedings. Arbitration is basically a single instance procedure where the parties by agreement waive their right to appeal on substantive grounds. However, this does not preclude the parties the right to due process. The possibility to challenge an arbitral awar
Bakgrund: Hälso- och sjukvården genomgår kontinuerligt omorganiseringar och utsätts för ständiga ekonomiska besparingar. Samtidigt ställer sjukvårdens snabba utvecklingstakt krav på ett ledarskap som kan hantera den problematik som en komplex verksamhet innebär. Konsekvenserna av förändringsarbetet har blivit att avdelningar har slagits samman och cheftätheten har blivit glesare. De chefer som är Introduction: The health care system is undergoing continuous reorganizations and subjected to constant demands for financial savings. The rapid pace of development requires leadership that can deal with the issues that arise in this complex operation, however, the impact of these changes have resulted in consolidated departments and fewer staff. The managers who are left will be responsible for u
Bison bonanza: En dag i visentens liv Den europeiska bisonen, visenten (Bison bonasus) är den amerikanska bisonoxens (Bison bison) mindre kända släkting och likväl Europas största vilda däggdjur. Misströsta inte om du helt missat att detta stora oxdjur vandrar i Central- och Östeuropas landskap. Visenten dog nämligen ut i det vilda redan under 1920-talet och har senare blivit återintroducerad medThe European bison (Bison bonasus), is the largest terrestrial mammal in Europe and a possible keystone species. Having previously been extinct in the wild, the European bison faces several severe challenges, such as lack of suitable habitat, habitat fragmentation, isolation of populations, small population sizes and a very limited gene pool. Nonetheless, after a long period of regulated matings a
BACKGROUND: This study aimed to evaluate the prevalence of pathogenic/likely pathogenic cardiomyopathy variant carriers in a multiancestry US population and examine the risk of adverse clinical outcomes. METHODS: This retrospective cohort study included multiancestry US adults aged ≥18 years with sequencing data from the All of Us Research Program. Pathogenic/likely pathogenic variants in cardiomy
A substantial external force transmitted to the brain may cause a severe traumatic brain injury (sTBI) , resulting in structural brain damage and/or functional impairment. Despite progress in management, traumatic brain injury remains a major cause of severe disability and death. This thesis evaluates treatment strategies and novel interventions in children and adults with sTBI and comprises the f
BACKGROUND: The ORBITA and ORBITA-2 trials have provided valuable insights into the effects of coronary revascularization in chronic coronary syndrome (CCS). However, uncertainties remain regarding the efficacy of revascularization on symptoms in large real-world populations. To evaluate the efficacy of revascularization, we used dispensed long-acting nitrates as a proxy for the presence of angina
Scope: Vascular graft or endograft infection (VGEI) is a severe complication requiring a multidisciplinary approach combining surgery and antimicrobial therapy. This study aimed to develop expert consensus on the management and follow-up of VGEI, with a focus on antimicrobial strategies. Methods: A modified Delphi method was conducted to reach consensus on key aspects of VGEI care, including antim
Importance: Emerging evidence suggests that cholesterol plays a role in breast cancer (BC) metabolism, raising the possibility that cholesterol-lowering medications, such as statins, may improve BC prognosis. Objective: To evaluate the association between postdiagnosis statin initiation and BC mortality using an emulated target trial approach. Design, Setting, and Participants: This observational
