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Cerebrospinal fluid levels of complement proteins C3, C4 and CR1 in Alzheimer's disease

Alzheimer's disease (AD) is strongly associated with loss of synapses. The complement system has been shown to be involved in synaptic elimination. Several studies point to an association between AD and the complement system. The purpose of this study was to examine the association of cerebrospinal fluid (CSF) levels of complement components 3 and 4 (C3 and C4, respectively), and complement recept

Indirect Effects in Evidential Assessment: A Case Study on Regression Test Technology Adoption

Background: There is a need for ecient regression testing in most software development organizations. Often the proposed solutions involve automation. However, despite this being a well researched area, research results are rarely applied in industrial practice. Aim: In this paper we aim to bridge the gap between research and practice by providing examples of how evidence-based regression testing

Kroppar i nationens tjänst: en studie av statens kontroll av patologiserade kroppars reproduktion

This is a study of the Swedish governments control over pathologicalized bodies. I have carried out a genealogical analysis of Swedish government official reports concerning forced sterilizations. The purpose of the study was to find out in which ways the Swedish government controls and restricts “certain kinds” of bodies when it comes to reproduction. With theoretical influences from Judith Butle

Att se de osynliga barnen - om barn till föräldrar med psykisk sjukdom och konsekvenserna av strävan efter normalitet och undvikandet av stämpling av psykisk sjukdom

Author: Mikaela Bryland Title: To see the invisible children – about children with parents suffering from mental illness and the consequences of the search for normality and the avoidance of stigmatisation [translated title] Supervisor: Gunilla Fredin Assessor: Sune Sunesson The purpose of this study was to examine the children with parents suffering from mental illness and their situation when t

Cultural collisions in social work – The case of Aboriginal clients in Australia

Problems in social work with aboriginal clients in Australia are analysed in this thesis. The cultural collision between Western social workers and aboriginal clients is interpreted as the result of poor insight into the culturally determined worldview, the value system, norms and conceptions held by many aboriginal clients. More specifically, the collision is expressed in communication problems

Lack of concealment may lead to selection bias in cluster randomized trials of palliative care

Comprehensive palliative care programs are often implemented on a community level, and to evaluate such interventions, randomization by cluster (community) may be the only feasible method. In trials randomizing individual subjects, the importance of proper concealment has been stressed, In cluster randomized trials, however, concealment of individual patient allocation is often impossible. The fol

The reality of old moving groups - the case of HR 1614 - Age, metallicity, and a new extended sample

We prove the existence of the old and metal-rich moving group HR 1614. This is done using the new Hipparcos parallaxes in combination with metallicities derived from Strömgren photometry, supported by dynamical simulations of the evolution of old moving groups in the galactic potential. A new selection criterion for this moving group is presented as well as a new, extended sample of probable membe

Food product development - A consumer-led text analytic approach to generate preference structures

Purpose - This paper aims to illustrate a new method to cluster consumer attribute preferences and to transform spontaneously written texts by consumers about a certain favourite food product (hamburger) into distinct preference clusters of attributes. Design/methodology/approach - A new way of finding significant clusters of consumer attribute preferences is developed by means of a new text analy

Induction of platelet thrombi by bacteria and antibodies

We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai

Identification of a Catalytic Exosite for Complement Component C4 on the Serine Protease Domain of C1s

The classical pathway of complement is crucial to the immune system, but it also contributes to inflammatory diseases when dys-regulated. Binding of the C1 complex to ligands activates the pathway by inducing autoactivation of associated C1r, after which C1r activates C1s. C1s cleaves complement component C4 and then C2 to cause full activation of the system. The interaction between C1s and C4 inv

Nocturnal migratory songbirds adjust their travelling direction aloft: evidence from a radiotelemetry and radar study.

In order to fully understand the orientation behaviour of migrating birds, it is important to understand when birds set their travel direction. Departure directions of migratory passerines leaving stopover sites are often assumed to reflect the birds' intended travel directions, but this assumption has not been critically tested. We used data from an automated radiotelemetry system and a tracking

Combined Innovation Policy: Linking Scientific and Practical Knowledge in Innovation Systems

New research indicates that firms combining the science-based STI (Science, Technology, Innovation) and the experience-based DUI (Doing, Using, Interacting) modes of innovation are more efficient when it comes to improving innovation capacity and competitiveness. With regard to innovation policy, the STI mode calls for a supply-driven policy, typically aimed to commercialize research results. The

Ethyl(hydroxyethyl)cellulose-sodium dodecanoate interaction investigated by surface tension and electrical conductivity techniques

Mixtures of ethyl (hydroxyethyl)cellulose (EHEC) and sodium dodecanoate (SDoD) were investigated using surface tension, conductivity and transmittance measurements. The parameters of the surfactant to polymer association processes such as the critical aggregation concentration (cac) and saturation of the polymer by SDoD (psp) were determined from the plots of surface tension and specific conductiv

Production of phi mesons at midrapidity in root S-NN=200 GeVAu+Au collisions at relativistic energies

We present the results of phi meson production in the K+K- decay channel from Au+Au collisions at root s(NN) =200 GeV as measured at midrapidity by the PHENIX detector at Brookhaven National Laboratory's Relativistic Heavy Ion Collider. Precision resonance centroid and width values are extracted as a function of collision centrality. No significant variation from the Particle Data Group accepted v

A gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11

Genome-wide nonparametric linkage analysis of 480 sib-pairs affected with type 2 diabetes revealed linkage to a previously unreported susceptibility locus on chromosome 18p11. This result improved with stringent subphenotyping using age- and sex-adjusted BMI, ultimately reaching a logarithm of odds of 3.82 (allele sharing 0.6654) at a point between markers D18S976 and D18S391 when the most obese 2

The Marte Meo Method as a means of supporting new adoptive parents

The study discussed here by Gunnel Osterman, Anders Möller and Ingegerd Wirtberg aimed to find out if any observable themes or patterns recur when using the Marte Meo (MM) method with adoptive parents, and if the parents feel that working with this method helps them to interact with their child. The study used qualitative methods and comprised two parts: use of the MM method with couples who had a

Experiential avoidance as an emotion regulatory function: an empirical analysis of experiential avoidance in relation to behavioral avoidance, cognitive reappraisal and response suppression

he purpose of the present study was to empirically test the suggestion that experiential avoidance in an emotion regulation context is best understood as an emotion regulatory function of topographically distinct strategies. To do this we examined whether a measure of experiential avoidance could statistically account for the effects of emotion regulation strategies intervening at different points

Cytonuclear Interactions and the Economics of Mating in Seed Beetles

Recent studies have uncovered an abundance of non-neutral cytoplasmic genetic variation within species, which suggests that we should no longer consider the cytoplasm an idle intermediary of evolutionary change. Nonneutrality of cytoplasmic genomes is particularly intriguing, given that these genomes are maternally transmitted. This means that the fate of any given cytoplasmic genetic mutation is

Losing the Issue, Losing the Vote: Issue Competition and the Reform of Unemployment Insurance in Germany and Sweden

Welfare state research tends to assume strong and enduring public support for welfare state institutions. We challenge this assumption and show that in times of economic crisis, positive welfare state attitudes are confronted with conflicting preferences for improvement of labour market performance. We argue that such movements in public opinion have led to issue competition among major political

Self-fertilization and inbreeding limit the scope for sexually antagonistic polymorphism

Sexual antagonism occurs when there is a positive intersexual genetic correlation in trait expression but opposite fitness effects of the trait(s) in males and females. As such, it constrains the evolution of sexual dimorphism and may therefore have implications for adaptive evolution. There is currently considerable evidence for the existence of sexually antagonistic genetic variation in laborato