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Popular Abstract in English Globalization and new technologies in transportation and communication have opened the doors for partnerships beyond the national and regional borders, making business survival more complex than ever before. We can see more companies outsourcing different aspects of their business in order to focus on one or a few core competencies, which would potentially gain them morIn this dissertation, we discuss how buyers practice purchasing strategies in an asymmetric power situation favoring suppliers, and how their purchasing strategies practiced impact their purchasing power and buyer-supplier relationships. Organizations enter exchange relationships to access required resources not produced internally, and are exposed to uncertainty from not being able to fully contr

Aims: Use of left ventricular assist devices (LVADs) in older patients has increased, and assessing outcomes in older LVAD recipients is important. Therefore, this study aimed to investigate associations between age and outcomes after continuous-flow LVAD (cf-LVAD) implantation. Methods and results: Cf-LVAD patients from the multicentre European PCHF-VAD registry were included and categorized into

BACKGROUND AND AIMS: In 2019, the EAT-Lancet Commission proposed a mainly plant-based diet that nurtures human health and supports environmental sustainability. However, its association with type 2 diabetes (T2D) has not been widely studied, and it remains unclear whether genetic susceptibility for T2D can modify this association. The aim was therefore to investigate the association between the EA

The derivation of dopamine neurons from human embryonic stem cells (hESCs) now offers a promising alternative to fetal tissue for cell replacement therapy (CRT) in Parkinson´s disease (PD). Using the appropriate chemical cues in vitro, hESCs can be patterned towards bona-fide ventral midbrain (VM) DA neurons that survive, reinnervate, release DA and provide functional recovery when transplanted in

Differences between 10Be records from Greenland and Antarctica over the last 100 years have led to different conclusions about past changes in solar activity. The reasons for this disagreement remain unresolved. We analyze a seasonally resolved 10Be record from a firn core (North Greenland Eemian Ice Drilling [NEEM] ice core project) in Northwestern Greenland for 1887–2002. By comparing the NEEM d

Bone mineral density (BMD) is an established measure used to diagnose patients with osteoporosis. In clinical trials, change in BMD has been shown to provide a reliable estimate of fracture risk reduction, and achieved BMD T-score has been shown to reflect the near-term risk of fracture. We aimed to test the association between BMD T-score and fracture risk in patients treated for osteoporosis in

Conditions experienced early in development can affect the future performance of individuals and populations. Demographic theories predict persistent population impacts of past resources, but few studies have experimentally tested such carry-over effects across generations or cohorts. We used bumble bees to test whether resource timing had persistent effects on within-colony dynamics over sequenti

In addition to the standard set of translation factors common in eukaryotic organisms, protein synthesis in the yeast Saccharomyces cerevisiae requires an ABCF ATPase factor eEF3, eukaryotic Elongation Factor 3. eEF3 is an E-site binder that was originally identified as an essential factor involved in the elongation stage of protein synthesis. Recent biochemical experiments suggest an additional f

Abstract Background: Osteoarthritis (OA) is a disabling joint disease affecting about 300 million people worldwide. Today, there is no cure for OA and treatment focuses on relieving symptoms. Guidelines recommend education, exercise, and weight control, as first-line treatment. In Sweden, first-line treatment is offered as a Supported Osteoarthritis Self-Management Programme (SOASP) combining educ

Objective: The Systemic Lupus International Collaborating Clinics (SLICC) frailty index (FI) predicts mortality and damage accrual in systemic lupus erythematosus (SLE), but its association with hospitalizations has not been described. Our objective was to estimate the association of baseline SLICC-FI values with future hospitalizations in the SLICC inception cohort. Methods: Baseline SLICC-FI sco

Real-time communication over Ethernet is becoming important in various application areas of cyber-physical systems such as industrial automation and control, avionics, and automotive networking. Since such applications are typically time critical, Ethernet technology has been enhanced to support time-driven communication through the IEEE 802.1 TSN standards. The performance and stability of contro

Pottery technology, originating in Northeast Asia, appeared in Alaska some 2800 years ago. It spread swiftly along Alaska's coastline but was not adopted on Kodiak Island until around 500 cal BP, as part of the Koniag tradition. While in the southeast pottery was used extensively, people on the northern half of the island did not adopt the technology. What drove these patterns of adoption and non-

Although many nations in Sub-Saharan Africa (SSA) have recently recorded impressive economic growth, and several countries could attain middle-income status in the next decade, there is no or little concurrent advance in health biotech with little capabilities for manufacturing of medicines, medical supplies, and health commodities in the region. They import majority of medicines, medical supplies

This article offers the first empirical and cross‐national analysis of citizens’ views about the democratic importance of the public sphere. We first identify three normative functions that public spheres are expected to perform in representative democracies: they provide voice to alternative perspectives, they empower citizens to criticise political authorities and they disseminate information on

Introduction: Ankle fractures are commonly treated by open reduction and internal fixation with plate and screws. Unplanned return to theatre is common, in many cases to extract prominent osteosynthesis material from the lateral malleolus as swelling subsides. We hypothesised that patients operated with a posterolateral plate placement on the lateral malleolus would have fewer reoperations, and fe

Background: Fulminant myocarditis (FM) is a form of acute myocarditis characterized by severe left ventricular systolic dysfunction requiring inotropes and/or mechanical circulatory support. A single-center study found that a patient with FM had better outcomes than those with acute nonfulminant myocarditis (NFM) presenting with left ventricular systolic dysfunction, but otherwise hemodynamically

The workshop will focus on what first-year students to higher education needs to be successful and how a peer learning programme might address those needs. (~5 min for introduction)The workshop will start with a brainstorm session where participants in small groups will share thoughts and ideas on the question (~20 min for activity): “What would you like to affect with your new students? Provide s

Populärvetenskaplig sammanfattningDet senaste århundradet har den tekniska utvecklingen gått snabbt inom många områden. Jordbruket är ett av dessa. Idag upptas ungefär en tredjedel av jordens landyta av jordbruk och boskapsskötsel. Utvecklingen av jordbruket har inneburit att vi idag kan producera mer mat än någonsin, men den har också inneburit intensivare brukningsmetoder, genom till exempel ökaAbstractHuman ingenuity and activities have resulted in erosion of ecosystems and their capacity to support the sustainable production of goods and functions that we depend on. Biodiversity i.e. the diversity within and between species and of ecosystems, underpins many of the ecosystem functions critical for human well-being and resilience, and is declining faster than at any time in human history

Sexual antagonism occurs when there is a positive intersexual genetic correlation in trait expression but opposite fitness effects of the trait(s) in males and females. As such, it constrains the evolution of sexual dimorphism and may therefore have implications for adaptive evolution. There is currently considerable evidence for the existence of sexually antagonistic genetic variation in laborato

Objective: To evaluate the internal consistency of the Hip disability and Osteoarthritis Outcome Score-Physical Function Short-form (HOOS-PS) and the Knee injury and Ostecarthritis Outcome Score-Physical Function Short-form (KOOS-PS) in total hip replacement (THR) and total knee (TKR) replacement. Construct validity and responsiveness were compared to the Western Ontario McMaster Universities' Ost