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Sepsis is one of the leading causes of mortality in the world. Currently, the heterogeneity of sepsis makes it challenging to determine the molecular mechanisms that define the syndrome. Here, we leverage population scale proteomics to analyze a well-defined cohort of 1364 blood samples taken at time-of-admission to the emergency department from patients suspected of sepsis. We identified panels o
A commonly held assumption is that demonstration and pantomime differ from ordinary action in that the movements are slowed down and exaggerated to be better understood by intended receivers. This claim has, however, been based on meagre empirical support. This article provides direct evidence that the different functional demands of demonstration and pantomime result in motion characteristics tha
In order to give adequate support to risk managers, new risk assessment methods should be developed that are (1) scientifically sound, (2) simplified, and (3) suited for precautionary risk management. In this Perspective we propose that the notion of a precautionary default can be a useful tool in the development of such methods. A precautionary default is a cautious or pessimistic assumption that
Whittaker was one of the leading ecologists of his generation, introducing several ideas to plant community ecology. One approach involved deriving environmental-correlation curves in attempts to determine how the abundance of individual species changed along environmental gradients. These curves have been used extensively in the ecological literature of the last 50 years. However, there has been
Global competition forces companies to constantly increase the efficiency in their production systems. One important factor affecting the production performance is the inbound materials handling system. When designing or relocating a manufacturing system, the cost of the material handling system is one of many things to take into consideration. In connection with on-going research a comprehensive
The aim of this study was to illuminate the lived experiences of families where a child had survived 7 years from a diagnosis of childhood cancer. This article describes one part of an inductive and longitudinal research project that included 17 families. Four families whose child was diagnosed with cancer 7 years previously were interviewed using a hermeneutical phenomenological approach. The fam
The self-assembly of proteins into beta-sheet-rich amyloid fibrils has been observed to occur with sigmoidal kinetics, indicating that the system initially is trapped in a metastable state. Here, we use a minimal lattice-based model to explore the thermodynamic forces driving amyloid formation in a finite canonical (NVT) system. By means of generalized-ensemble Monte Carlo techniques and a semi-an
Effect of aluminium on microstructure and properties of austenitic heat resistant steel was investigated. The results showed that Al addition led to formation of spheroidal and dispersed Ni3Al. After solution treatment, Ni3Al particles experienced a significant refinement from 1.5 μm to nanoscale (∼80 nm). Matrix transformed from austenite to ferrite when addition of Al was >4.72%. Oxidation resis
There are fundamental unresolved questions about the nature of the long-run interplay between innovation and economic development processes. This study examines technological transitions in Sweden, 1908-2016, using a new literature-based innovation output indicator for the engineering industry, allowing a mixed-methods approach. The results suggest that waves of innovation have taken place during
Ecological modernisation in the form of support to the notion of green growth remains the dominant discourse in environmental policy globally. Still, questions of limits to economic expansion and growth on a planet with finite natural resources have been at the core of environmental discourses at least since the 1970's. A recent effort by Stoknes and Rockström (2018) seeks to unite notions of ecol
The EU's farmers are no longer required to produce commodities to receive direct payments as long as they keep their land in good condition. Some believe this is bad for development because it encourages passive farming. We evaluate, using a real options approach, the implications of decoupled payments for the desirability and optimal timing of agricultural land development when considering sunk i
International media regularly portray North Korea as abnormal, run by a leadership depicted in turns as evil, incompetent, all-powerful, and farcical. Such representations provide reason for publics not to question American-led preferences, dominant until 2018, for sanctions and threats over dialogue when responding to weapons development. How does a region beyond the Asia-Pacific, home to potenti
Ida WingrenMilena Arias Schreiber Sebastian LinkeBreaking out of the neoliberal market agenda? Developing expertise to support local coastal community-based fisheries in SwedenFisheries management lays bare many of the tensions and contradictions between community wellbeing and livelihoods on one hand and impositions of neoliberal market approaches to sustainability on the other. This causes probl
The aim of this study was to investigate the meaning of social adaptation among solid organ transplant recipients one year after transplantation. We analysed in-depth interviews from 16 solid organ transplant recipients by means of phenomenological hermeneutics. The informants comprised 11 men and five women with a mean age of 54 years, who had received a kidney, a liver or a heart. We found the o
Cell-extracellular matrix interactions are crucial for the development of an organism from the earliest stages of embryogenesis. The main constituents of the extracellular matrix are collagens, laminins, proteoglycans and glycosaminoglycans that form a network of interactions. The extracellular matrix and its associated molecules provide developmental cues and structural support from the outside o
Humans have an inquiring mind. Throughout history, one may find documentation that shows on human curiosity, and our drive to stretch boundaries to satisfy it. Thus, this is not something that characterizes our time in any particular way. Sources, for instance, from the 13th century can serve as good examples that support such an assumption. Mary Shelley’s novel from the 19th century, “Frankenstei
This review discusses the role arbuscular mycorrhizal fungi play in the regulation of plant nutrient transporter genes. Many plant nutrient transporter genes appear to be transcriptionally regulated by a feed-back mechanism that reduces their expression when the plant reaches an optimal level of nutrition. Their down-regulation in mycorrhizal roots, therefore, would be predicted as a result of sym
