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Nuclear orphan receptor TLX (Drosophila tailless homolog) is essential for the maintenance of neural stem/progenitor cell self-renewal, but its role in neuroblastoma (NB) is not well understood. Here, we show that TLX is essential for the formation of tumor spheres in three different NB cell lines, when grown in neural stem cell media. We demonstrate that the knock down of TLX in IMR-32 cells dimi
Popular Abstract in Swedish Syftet med denna studie var att (I) utvärdera sambandet mellan övervikt mätt med det s.k. body mass index (BMI) och operation med höftleds- eller knäledsprotes (konstgjord led) på grund av artros, (II) utvärdera sambandet mellan mekanisk belastning på grund av yrke och operation med höftleds- eller knäledsprotes på grund av artros, (III) utvärdera naturalförloppet för eThe purpose of this study was to (I) assess the association between body mass index (BMI) and total hip replacement (THR) and total knee replacement (TKR) due to osteoarthritis (OA), (II) assess the association between the mechanical load of work and THR and TKR due to OA, (III) evaluate the natural history of radiographic hip OA with regards to THR and hip fracture, (IV) to determine the prevalen
Background. Bioincompatible glucose degradation products (GDPs) in fluids for peritoneal dialysis (PD) develop during sterilization and storage. Their biological activity has successfully been monitored through the use of various in vitro methods but their molecular and chemical nature is less well understood. Many GDPs are highly reactive carbonyl compounds. Although some of the identified GDPs a
The importance of different additional simplifications used when moving from single site applications to regional applications of the SAFE and MAKEDEP models was studied. The SAFE model is a dynamic soil chemistry model, which apart from physical and chemical soil parameters also needs the historic evolution of atmospheric deposition and nutrient uptake to simulate the effects of acidic deposition
Degradation of toxaphene in soil from both newly contaminated (from Sweden) and aged spills (from Nicaragua) were studied. The newly contaminated soil contained approximately 11 mg kg(-1) toxaphene while the aged Nicaraguan soil contained approximately 100 mg kg-1. Degradation was studied in anaerobic bioreactors, some of which were supplied with lactic acid and others with Triton (R) X-114. In th
Aim: Studying changes between the ages of 20 and 35 in the use of alcohol and its meaning to the user and the relation of this to cultural background. Data and method: Qualitative interviews with 42 persons in Malmö, Sweden, aged approximately 20 years (21 women and 21 men) belonging to 3 groups, differing in social characteristics in their use of alcohol and the meaning it had for them. 34 of the
Relativistic channels are generated in an under-dense plasma by means of subpicosecond laser pulses. The channel extension is characterized via the Thomson-scattered light and the impact of the laser pulse duration and chirp are studied. It is shown that, under certain conditions, the channel extends further when the pulse duration is increased. This is in contrast to many earlier reports, where t
We theoretically investigate the mechanism of chemical enhancement of surface-enhanced resonance Roman scattering (SERRS) of para-aminothiophenol (PATP)/metal complexes and metal/PATP/metal junctions. The method of charge difference density is used to visualize intracluster excitation and charge transfer (CT) between PATP and metal during the process of resonant electronic transitions. It is found
Objective. The present study investigates the cross-sectional relationship between tobacco smoking and body fatness. Methods. This cross-sectional study consisted of 469,543 men and women who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study between 1992 and 2000 providing anthropometric measurements and information on smoking. Adjusted multilevel mixed-
INTRODUCTION The actual heat loss may be underestimated especially in studies employing mild whole-body cooling, if AVA-rich distal areas are not taken into account. In the present report, we illustrate the skin temperature response pattern in fingers (rich in AVAs) to transient whole-body cooling as compared to non-acral body sites (without AVAs). METHODS Eight men participated in the study. Duri
The problem addressed in this thesis is how to account for environmental aspects when purchasing freight transports. This problem is addressed from a transport purchasing perspective. The result of the research is a model for how transport purchasers can incorporate environmental aspects when purchasing freight transports. This mode! is built on two tools and a work process. The first too! is a st
Popular Abstract in SwedishUnder slutet av 1950-talet, ungefär samtidigt med tv:s etablering, innehade Sverige Europarekordet vad gäller antalet biografer. Folk gick på bio som aldrig förr. Biograferna att spela en mycket stor roll för film- och biografkulturens tillgänglighet och spridning. Den här boken handlar om att gå på bio. Genom att gå på bio lärde sig människor att se och uppleva film ochGoing to the Pictures The Cinema as a Meeting Place in the 1940s and 1950s Summary At the end of the 1950s, at roughly the same time as television became established, Sweden had the largest number of cinemas of any country in Europe. People went to the cinema in unprecedented numbers. In 1956 ticket sales in Swedish cinemas reached 80 million. There were palatial cinemas which offered people a f
We use a microscopic Slater-Koster tight-binding model with short-range exchange and atomic spin-orbit interactions that realistically captures generic features of ferromagnetic metal nanoparticles to address the mesoscopic physics of magnetocrystalline anisotropy and hysteresis in nanoparticle-quasiparticle excitation spectra. Our analysis is based on qualitative arguments supported by self-consi
Aims. We aim to study the variability properties of bright hard X-ray selected active galactic nuclei (AGN) in the redshift range between 0.3 and 1.6 detected in the Chandra Deep Field South (XMM-CDFS) by a long (∼3 Ms) XMM observation. Methods. Taking advantage of the good count statistics in the XMM CDFS, we search for flux and spectral variability using the hardness ratio (HR) techniques. We al
The aim was to compare two different regimens for children diagnosed with type 1 diabetes, hospital-based care and hospital-based home care (HBHC), in terms of the child's metabolic control, episodes of severe hypoglycaemia, the disease's impact on family and the parents' health-related quality of life, one year after diagnosis. The study had a randomised controlled design and included 60 children
Future global temperature change will have significant effects on society and ecosystems. Earth system models (ESM) are the primary tools to explore future climate change. However, ESMs have great uncertainty and often run at a coarse spatial resolution (usually about 2°). Accurate high-spatial-resolution temperature dataset are needed to improve our understanding of temperature variations and for
When it comes to the field of drug studies, researchers have tended to privilege men’s perspectives and experiences, assuming women to be mostly marginal, as primarily victims and accomplices. Further, when women’s experiences are taken into account, a view of them as only women has tended to be pushed to the forefront. As such, we are sorely lacking research departing from women’s own recollectio
The maritime industry is undergoing a transition towards alternative fuels to reduce greenhouse gas emissions. These fuels influence engine exhaust gas characteristics and consequently affect the performance of waste heat recovery (WHR) systems. This study investigates the impact of fuel type on the recoverable exhaust gas exergy of marine two-stroke engines and evaluates the suitability of differ
The favorable pharmacokinetics of MMC, used during intraperitoneal chemotherapy, has been reported in several studies [11-19]. A major safety issue in studies using intraperitoneal chemotherapy perfusion is the resulting systemic drug exposure. The AUCplasma is determined by the dose, the clearance, and the fraction absorbed from the peritoneal cavity. The reported mean plasma peak concentrations
To study the role of the mossy fiber afferents to the cerebellum in classical eye-blink conditioning, in particular the timing of the conditioned responses, we compared the effects of varying a peripheral conditioned stimulus with the effects of corresponding variations of direct stimulation of the mossy fibers. In one set of experiments, decerebrate ferrets were trained in a Pavlovian eye-blink c
