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Popular science summary: Predictive model for unbound brain-to-plasma concentration ratio Blood-brain barrier (BBB) is a dynamic interface evolved to protect the brain from exposure to toxic xenobiotics and to maintain homeostasis. Distribution of drugs across BBB is critical for any drug discovery project. A drug designed for a target in brain has to pass through the BBB in sufficient concentr
Validation of gene × environment interaction results from epidemiological studies in randomized clinical trials (RCTs) is usually hampered by insufficient statistical power. Genotype-based recall (GBR) refers to the design of studies in which subgroups of the population are selected based on their genotypes. In this thesis we test if a GBR approach of recruiting two groups of participants with dis
Investeringsrådgivning är när en personlig rekommendation avseende ett finansiellt instrument lämnas till en kunde. Det finns inga begränsningar i hur det ska gå till, utan det kan både genom ett fysiskt möte och via ett automatiskt verktyg. Vid investeringsrådgivning finns det omfattande krav som måste uppfyllas. Kraven handlar huvudsakligen om information som ska lämnas till kund, en bedömning aProviding investment advice is the act of giving a personalized investment advice to a client in relation to a financial instrument. There is no set form for how investment advice is provided, it can be done by a person in a meeting, as well as by an automated tool. The legislation that must be complied with while providing investment advice is extensive. The legislation mainly stipulates three re
This thesis examines the utilization of internal controls as means of facilitating effective use of free cash flow (FCF) by managers, with the aim of preventing potential issues that may distort their relationship with shareholders. The objective was to understand the means of mitigating FCF issues by identifying internal controls within the companies to guarantee the effective utilization of cash
When humans are involved, things can go wrong. This is a statement as factually true and yet dramatically undefined and dangerously ambiguous as any. No matter the industry or domain, where humans interact with other humans, perfect predictability is impossible and a focus on negative outcomes can seem natural. When outcomes are anything less than ideal and when these events and outcomes are made
Purpose: The purpose of this study is to investigate if institutional ownership has an impact on a firm’s total payout ratio in Swedish firms. Methodology: The study uses fixed effects models with robust standard errors clustered by firm with year effects and provides several robustness checks by altering the dependent variable in our analysis. Theoretical perspectives: The theoretical framework
Background: For most patients with end stage renal disease (ESRD) kidney transplantation is the best treatment option. Best outcomes are achieved with living donation. To increase access to living donation for patients who are not compatible with their living donors, Kidney Exchange Programs (KEPs) have evolved. By exchanging donors, compatibility can be achieved thus enabling transplantation.
Den svenska avtalslagen, med tillhörande principer, har existerat i över 100 år. Parallellt med att avtalsrätten stått stadigt har den teknologiska utvecklingen tagit markanta kliv framåt. De metoder för avtalsslut som var i åtanke vid utformandet av lagen är vitt skilda från de metoder som finns tillgängliga i dag. Detta har, än så länge, inte visat sig vara ett större problem. De regler och prin
I denna scoping review har syftet varit att söka efter forskning kring vilket behov föräldrar har av stöd för att kunna prata om sexualitet med sina barn som har funktionsnedsättning och om det finns beprövad intervention. Totalt nio artiklar har granskats som har innefattat barn med autismspektrumtillstånd (AST), intellektuell funktionsnedsättning (IF) och rörelsenedsättning (RH). Resultatet visa
The primacy of hegemonic structures that shape political processes is relevant to purvey an extensive grasp of which central power dynamic is in effect. The United States has a significant role in the international context and frequently incurs the attention of the world when dealing with issues of global nature. This paper studies how American Exceptionalism, a tendency on the U.S. part to view i
Situated in Geneva, Switzerland, the Large Hadron Collider is largest particle accelerator in the world, and as such, its operation carries with it some of the greatest technical challenges ever faced. Among them are the huge demands put on data storage capacity by experiments in particle physics, both in terms of rate and volume of data. Several systems are employed to manage and reduce the flow
Sweden has for the last half-century had a very high consumption of dairy products compared to other European countries. This high demand in cow’s milk puts a lot of pressure on the dairy industry which requires a high amount of feed, water and energy to produce dairy products. These factors combined with the rumination that occurs when cows eat is the origin of the release of greenhouse gases (GH
Colombia committed to reduce 20% of its emissions by 2030 in the framework of Paris Agreement. The study provides a systemic approach that considers the two main drivers of the emissions in the country to know how realistic is the mentioned intended National Determined Contribution (iNDC). It analyzes deforestation and road transport with a methodology that combines analyses of their current situa
En rad internetbaserade tjänster finansieras idag genom att samla in data om sina användare för att sedan sälja riktat reklamutrymme till andra aktörer. Konsumenter får ofta tillgång till tjänsterna inte genom att betala pengar, utan i stället genom att tillhandahålla sina personuppgifter och acceptera att dessa behandlas i marknadsföringssyfte. Genom EU-direktiv 2019/770 och dess implementation A number of internet-based services are in today’s digital economy financed by collecting data about their users in order to sell targeted advertising space to other actors. Consumers often gain access to these services not by paying money, but by providing their personal data and allowing for it to be process-sed for marketing purposes. Through EU Directive 2019/770 and its implementation in the
Background and Purpose: In recent years, the treatment landscape for breast cancer has undergone significant advancements, with the introduction of several new anticancer agents. One such agent is trastuzumab emtansine (T-DM1), an antibody drug conjugate that has shown improved outcomes in both early and advanced breast cancer. However, there is currently a lack of comprehensive evidence regarding
New article on wetlands outside of Lund shows a trans-Holocene history of human activity New article on wetlands outside of Lund shows a trans-Holocene history of human activity Published 2 June 2025 A Mesolithic log with axe marks found in the Gullåkra mosse fills in gaps in our understanding of the wetland’s history. DarkLab members have published a new article detailing excavations in the Gul
Øresundsdagen 3 | Centre for Mathematical Sciences Skip to main content This site uses cookies to enhance the user experience. By continuing to use the site you agree that cookies are used according to our Cookie Policy (on the website of LTH) . Essential cookies These cookies are necessary for the website to function and cannot be turned off in our systems. These cookies do not store any personal
https://www.maths.lu.se/english/conferences/oeresunds-dagen-3/ - 2026-10-08
Mandatory assignments | Centre for Mathematical Sciences Skip to main content This site uses cookies to enhance the user experience. By continuing to use the site you agree that cookies are used according to our Cookie Policy (on the website of LTH) . Essential cookies These cookies are necessary for the website to function and cannot be turned off in our systems. These cookies do not store any pe
Matematikcentrum Matematik NF Sammanställning för MATA22 Lineär algebra 1, vårterminen 2024 Kursansvarig: Anna-Maria Persson Övriga lärare: Henrik Ekström, Frej Weiström Dahlin, Joakim Cronvall Antal studenter: 86 nyregistrerade samt 11 omregistrerade. 32 studenter har svarat på utvärderingen. Resultat på examinerande moment: - Projektuppgifter: 80 studenter klara med samtliga inlämningsuppgifter
https://www.maths.lu.se/fileadmin/maths/Matematik_NF/Kursutvaerderingar/VT2024/MATA22VT24.pdf - 2026-10-08
