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Omkring 10% av Sveriges befolkning lider av kronisk njursjukdom. För de flesta patienter med långt gången, så kallad terminal njursjukdom är njurtransplantation den bästa behandlingen, både för patientens livskvalitet och ur ett hälsoekonomiskt perspektiv. Många patienter som har en villig donator passar inte med denna på grund av icke kompatibla blodgrupper eller för att de har antikroppar motBackground: For most patients with end stage renal disease (ESRD) kidney transplantation is the best treatment option. Best outcomes are achieved with living donation. To increase access to living donation for patients who are not compatible with their living donors, Kidney Exchange Programs (KEPs) have evolved. By exchanging donors, compatibility can be achieved thus enabling transplantation.

This thesis examines the utilization of internal controls as means of facilitating effective use of free cash flow (FCF) by managers, with the aim of preventing potential issues that may distort their relationship with shareholders. The objective was to understand the means of mitigating FCF issues by identifying internal controls within the companies to guarantee the effective utilization of cash

Abstract The aim of this dissertation was to study those directly affected by the 2010 law on Coordinated Individual Plan (Samordnad Individuell Plan, SIP). How the service users experienced the implementation of SIP and how the plan came to affect them in their day-to-day work. The dissertation takes its point of departure in a discussion concerning the critique of psychiatric care, the well bei

Endotoxin exposure is associated with wheeze and asthma morbidity, while early life exposure may reduce risk of allergy and asthma. Unfortunately, it is difficult to compare endotoxin results from different laboratories and environments. We undertook this study to determine if lipopolysaccharide ( LPS) extraction efficiency could account for differences among laboratories. We generated and collect

Epilepsy is one of the most devastating neurological diseases and despite significant efforts there is no cure available. Occurrence of spontaneous seizures in epilepsy is preceded by numerous functional and structural pathophysiological reorganizations in the brain-a process called epileptogenesis. Treatment strategies targeting this process may be efficient for preventing spontaneous recurrent s

Fermentation of Ulva spp., a protein-rich green macroalga, offers a sustainable approach for utilising an available resource and developing functional food ingredients. However, its high levels of inorganic matter, polyphenols, and complex polysaccharides such as ulvan pose challenges to microbial metabolism. This study investigated the effects of various pretreatment strategies, including hot wat

Introduction: Wildfires pose escalating risks to communities at the wildland--urban interface, often necessitating extensive evacuations. This thesis explores how driving behaviour during wildfire evacuations differs from routine conditions and how these differences can be modelled to improve traffic simulations, thereby supporting more informed planning and response decisions by authorities.Objec

Stingless bees (Meliponini) are important pollinators in tropical ecosystems and very abundant in the Bolivian Yungas region; yet little is known about their foraging behavior and floral preferences. In this study, we combined melissopalynology, pollen analysis from honey, with plant-pollinator interactions network to investigate foraging behavior and niche overlap of three rescued stingless bee s

INTRODUCTION: Alzheimer's disease (AD) diagnosis has been based largely on clinical symptoms, despite their limited sensitivity and specificity. Biomarker use was proposed to support a more accurate and timely diagnosis. However, neuroimaging or cerebrospinal fluid (CSF) is rarely used in primary care due to their perceived invasiveness, cost, and need for appropriate infrastructure. Blood-based b

Parkinson's disease (PD) affects motor function through degenerative processes and synaptic transmission impairments in the basal ganglia. None of the treatments available delays or stops the progression of the disease. While α-synuclein pathological accumulation represents a hallmark of the disease in its idiopathic form, leucine rich repeat kinase 2 (LRRK2) is genetically associated with familia

A key task in the ESMERALDA project dealt with identifying appropriate case studies to test the ‘flexible methodology’ in its different stages of development. Case studies consist of working examples in which mapping and assessment of ecosystem services were applied to address specific decision-making problems. Testing is understood as an iterative process of co-learning that involves project part

Human embryonic stern cells (hESC) are now routinely cultured in many laboratories, and differentiation protocols are available to generate a large variety of cell types. In all ongoing ethical debate opinions of different groups are based oil varying sets of religious, historical, cultural and scientific arguments as well as oil widely differing levels of general information. We here give all ove

Emergency medicine service (EMS) systems in the five Nordic Countries have more similarities than differences. One similarity is the involvement of anaesthesiologists as pre-hospital physicians and their strong participation for all critically ill and injured patients in-hospital. Discrepancies do exist, however, especially within the ground and air ambulance service, and the EMS systems face seve

Aims/hypothesis: The HLA class II DQB1*0602 allele confers strong dominant protection against type 1 diabetes but protection is not absolute. The aim of this study was to identify markers within the HLA region that differentiate DQB1*0602 haplotypes and show different associations with disease risk. Methods: We defined alleles at eight microsatellite markers spanning the HLA region in a case-contr

Reconstructing the vortex wake of freely flying birds is challenging, but in the past few years, direct measurements of the wake circulation have become available for a number of species. Streamwise circulation has been measured at different positions along the span of the birds, but no measurements have been performed in the transverse plane. Recent findings from studies of bat wakes have pointed

The interference between vascular plants and peat mosses with respect to nitrogen and phosphorus was studied in a fertilization experiment and with respect to competition for light in a removal experiment in poor fens with either soligenous or topogenous hydrology using Narthecium ossifragum (L.) Huds. and three species of Sphagnum sect. Sphagnum as targets. Adding fertilizer either on the moss su

A major challenge in neuroscience is to resolve the connection between gene functionality, neuronal circuits, and behavior. Most, if not all, neuronal circuits of the adult brain contain a glutamatergic component, the nature of which has been difficult to assess because of the vast cellular abundance of glutamate. In this study, we wanted to determine the role of a restricted subpopulation of glut

Major databases on western clothing and their thermal properties are available, but information on non-western clothing is lacking. A recent ASHRAE project 1504 TRP, Extension of the Clothing Insulation Database for Standard 55 and ISO 7730 dealt with the issue. Simultaneously, a co-operation study at Indian workplaces allowed us to acquire some sets of the traditional clothes used at construction

Objectives. Accidents in health care, resulting in injury or death to the patient, are a matter of considerable concern. The aim of this study is to examine whether system weaknesses can contribute to these accidents, and if so, how. Design. Eight consecutive accidents reported to the Health Authority in Sweden were analysed using MTO (Man-Technique-Organization) analysis. Setting. Emergency care