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PURPOSE: To investigate the expression of the complement regulatory proteins CD46, CD55, and CD59 on peripheral leukocytes in neovascular age-related macular degeneration (AMD).DESIGN: Prospective, case-control study.METHODS: Thirty-five unrelated patients with neovascular AMD and 30 control individuals were included in this case-control study. All participants were subjected to a structured inter
The present article is concerned with mechanisms which are responsible for the exaggerated brain damage observed in hyperglycemic animals subjected to transient global or forebrain ischemia. Since hyperglycemia enchances the production of lactate plus H+ during ischemia, it seems likely that aggravation of damage is due to exaggerated intra- and extracellular acidosis. This contention is supported
Recognizing individual variability is essential for developing targeted, personalized medical interventions. Vocal fatigue is a prevalent symptom and complaint among occupational voice users, but its identification has yielded mixed results. Vocal fatigue is a complex issue with heterogeneous biophysiological responses to vocal demands among individuals. This research aims to classify individuals
Several studies have demonstrated strong agreement between routine clinical visual assessment and quantification, suggesting that quantification approaches could support assessment by less experienced readers or in challenging cases. However, all studies to date have implemented a retrospective case collection, and challenging cases were generally underrepresented. Methods: We included all partici
Aim: To explore the lived experience of the trusting nurse–patient relationship among patients admitted to internal medicine wards. Design: A qualitative study guided by van Manen's hermeneutic phenomenological approach. Methods: Semi-structured interviews were conducted with fourteen hospitalised patients in a Danish University hospital in 2024. Data were analysed through thematic reflection. Res
Why, despite decades of warnings and solutions, does unsustainable consumption still persist? What keeps societies locked into business as usual even when the consequences are clear? This book contends that part of the answer lies in the myths we adhere to – powerful narratives that normalise the status quo, limit imagination and delay the transition to sustainability. Gathering leading scholars f
While general trends in Central European postglacial recolonisation dynamics are relatively well known, we often lack studies on intermediate (meta-population, landscape) scales. Such studies are needed to increase our understanding of, for example, the location of refugia; emergence of endemism, rates and trajectories of postglacial migrations; and anthropogenic landscape changes. Here, we focuse
The degree of trophic specialization determines the ability of predators to cope with changing foraging conditions, but in predators that prey on hundreds of species it is challenging to assess, especially when prey identity varies among predator individuals and across space and time. Here, we test the hypothesis that a bat species foraging on flying insects like moths will show ample flexibility
Purpose: It is common for radiation oncologists (ROs) today to have a mixed arsenal of radiotherapy treatment modalities at their disposal. To optimize a clinic's use of its different treatment modalities, while at the same time giving every patient an optimal treatment, is not a trivial task. The purpose of this study was to give ROs a tool to choose between available modalities. This would help
This study aims at exploring disability, health-related quality of life (HrQoL), psycholog- ical distress, and psychological features in post-stroke patients with chronic pain. An observational cross-sectional study involving 50 post-stroke patients (25 with chronic pain and 25 without pain) was conducted. The primary outcome was the self-reported level of disability and HrQoL which were both asse
Telomeres are the conservative sequence repeats located at the end of linear chromosomes that have been the focus of intensive research across many disciplines over the last four decades. They function as a cap to protect the chromosome ends from fusion to other chromosomes and to prevent chromosome degradation. Telomere shortening is thought to be involved in ageing, reflecting or even causing ag
The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) comprising 181,522 cases among 1,165,690 participants of predominantly European ancestry. We detected 241 associations, including 30 new loci. Cross-ancestry meta-analysis with a
There is a knowledge gap about nurses’ use of social media in relation to and during the COVID-19 pandemic, which demands the upholding of a physical distance to other people, including patients and their relatives. The study aims to explore how nurses in the Scandinavian countries used social media for professional purposes in relation to the first 15 months of the COVID-19 pandemic. Qualitative,
Aim: The Swedish Social Board has implemented a support strategy to guide out-of-home care for children, which translates as children's needs in focus (CNIF) and includes a systematic health assessment. It was fully introduced into the Skåne province in 2012 and our study covered the first four years of the CNIF health assessments, from 2012 to 2015. Methods: We studied children aged 0–17 years in
A wide range of research school activities of the MEDEA ESR training programme were monitored through observations and repeated structured individual interviews with participating Early Stage Researchers (ESRs; i.e. doctoral students). In the early stage of the project, instructional video presentations of participating laboratories and key scientific principles turned out helpful for the early st
BACKGROUND: The principles of palliative care were developed in hospices and specialised palliative care units and have not been sufficiently adapted to and evaluated in nursing homes. Therefore, an educational intervention from an interprofessional education perspective was performed within the project Implementation of Knowledge-Based Palliative Care in Nursing Homes. The aim of this study was t
Many conservative public figures have claimed that Google Search exhibits a liberal bias in the links presented. Surprisingly, perhaps, the few scientific studies conducted so far have tended to support this claim. In the study reported here, we compared Google search engine result pages (SERPs) for 8 terms related to immigration across 8 geographically distinct locations (municipalities). For eac
BACKGROUND: Sustained intrauterine hypoxia causes some four million perinatal deaths annually worldwide. The condition is predicated by neonatal acidemia, as determined by pH in umbilical cord blood at birth. We aimed to evaluate the association between umbilical cord arterial pH and long-term outcomes up to 20 years of follow-up.STUDY DESIGN: Using a retrospective cohort design, umbilical cord ar
Declining butterfly abundance over recent decades coincides with both habitat loss and increasingly warmer springs. Warmer temperatures could pose a problem for ‘capital’ breeders, especially those species that enter winter diapause as a pupa or adult, since a higher metabolic rate pre-eclosion is expected to further deplete lipid stores needed for egg production. We undertook an experiment on Pie
