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Measuring the End of Life Premium in Cancer using Individual ex ante Willingness to Pay

For the assessment of value of new therapies in healthcare, Health Technology Assessment (HTA) agencies often review the cost per Quality-Adjusted Life-Years (QALY) gained. Some HTAs accept a higher cost per QALY gained when treatment is aimed at prolonging survival for patients with a short expected remaining lifetime, a so called End-Of-Life (EoL) premium. The objective of this study is to elici

Artificial neural networks for rapid WWTP performance evaluation: Methodology and case study

Reliable performance evaluation of wastewater treatment plants (WWTPs) can be done by simulating the plant behavior over a wide range of influent disturbances, including series of rain events with different intensity and duration, seasonal temperature variations, holiday effects, etc. Such simulation-based WWTP performance evaluations are in practice limited by the long simulation time of the mech

On the dosimetric behaviour of photon dose calculation algorithms in the presence of simple geometric heterogeneities: comparison with Monte Carlo calculations

A comparative study was performed to reveal differences and relative figures of merit of seven different calculation algorithms for photon beams when applied to inhomogeneous media. The following algorithms were investigated: Varian Eclipse: the anisotropic analytical algorithm, and the pencil beam with modified Batho correction; Nucletron Helax-TMS: the collapsed cone and the pencil beam with equ

311881 Lokalförsörjningsplan 2022

Lokalförsörjningsplan 2022 Lokalförsörjningsplan 2022 LUNDS UNIVERSITET FÖRORD .................................................................................... 5 1. LOKALFÖRSÖRJNING VID LUNDS UNIVERSITET ................6 1.1 Mål för Lunds universitets campus och lokaler ................ 7 1.2 Campusutveckling .......................................................... 8 1.3 Principer för lokal

https://www.staff.lu.se/sites/staff.lu.se/files/2022-05/311881_Lokalf%C3%B6rs%C3%B6rjningsplan%202022%20.pdf - 2026-05-07

Movement on Stairs During Building Evacuations

The time that it takes an occupant population to reach safety when descending a stair during building evacuations is typically estimated by measureable engineering variables such as stair geometry, speed, stair density, and pre-observation delay. In turn, engineering models of building evacuation use these variables to predict the performance of egress systems for building design, emergency planni

Enterococcus faecalis Infection Causes Inflammation, Intracellular Oxphos-Independent ROS Production, and DNA Damage in Human Gastric Cancer Cells

Background: Achlorhydria caused by e.g. atrophic gastritis allows for bacterial overgrowth, which induces chronic inflammation and damage to the mucosal cells of infected individuals driving gastric malignancies and cancer. Enterococcus faecalis (E. faecalis) can colonize achlohydric stomachs and we therefore wanted to study the impact of E. faecalis infection on inflammatory response, reactive ox

Kan man avgöra om en person ljuger? - Utsageanalys i domstol och vittnespsykologi

Domstolarna ställs ofta inför problematiken att värdera muntliga utsagor. Ibland är en utsaga den enda bevisningen i ett mål och det är ytterst viktigt att bevisvärderingen genomförs på ett grundligt sätt. Det finns inga lagregler som styr hur bevisvärderingen ska gå till. Trots principen om fri bevisprövning finns det dock krav på objektivitet och att värderingen sker utifrån allmänna erfarenhetsCriminal courts often face the complexity that follows the analysis of verbal statements. In some cases a statement constitute the only evidence and it is vital to carry out a thorough valuation of the evidence. Despite the lack of written law and the principle of free trial of evidence there is still a demand for objectivity and the use of general knowledge. The Supreme Court has written out that

Modelling the response of yields and tissue C:N to changes in atmospheric CO2 and N management in the main wheat regions of western Europe

Nitrogen (N) is a key element in terrestrial ecosystems as it influences both plant growth and plant interactions with the atmosphere. Accounting for carbon–nitrogen interactions has been found to alter future projections of the terrestrial carbon (C) cycle substantially. Dynamic vegetation models (DVMs) aim to accurately represent both natural vegetation and managed land, not only from a carbon c

The Impact of Global Warming on Marine Boundary Layer Clouds over the Eastern Pacific-A Regional Model Study

Cloud simulations and cloud-climate feedbacks in the tropical and subtropical eastern Pacific region in 16 state-of-the-art coupled global climate models (GCMs) and in the International Pacific Research Center (IPRC) Regional Atmospheric Model (iRAM) are examined. The authors find that the simulation of the present-day mean cloud climatology for this region in the GCMs is very poor and that the cl

The effect of medication reconciliation in elderly patients at hospital discharge.

Objective To assess the impact of medication reconciliation interventions on medication error rates when elderly patients are discharged from hospital to community care or nursing homes.Setting Elderly patients (>65 years) living in nursing homes or in their own homes with care provided by the community nursing system. Method All medical records containing information on drug treatment were collec

Patient perspectives on depot buprenorphine treatment for opioid addiction - a qualitative interview study

Background: Recently developed buprenorphine depot injections have the potential to reduce risk for diversion and misuse, and to increase adherence with fewer visits for supervised intake. However, it is unclear how patients perceive this new form of medication. The purpose of this study was to explore patients experiences of depot injections and their reasons for continuing, discontinuing, or dec

Accelerometer-Measured Physical Activity and Sedentary Behavior in Individuals With and Without Chronic Diseases : Cross-Sectional Results of 27,890 Adults From the Swedish CArdioPulmonary BioImage Study Cohort

Background: This study compared levels of physical activity (PA) and sedentary behavior (SB) in adults with and without chronic diseases or multimorbidity, acknowledging sociodemographic factors. Methods: A cross-sectional analysis was conducted with data from 27,890 participants (52% women), aged 50–64, from the Swedish CArdioPulmonary bioImage Study cohort. Over 1500 chronic diseases were includ

Unraveling the Genetics of Shared Clinical and Serological Manifestations in Patients With Systemic Inflammatory Autoimmune Diseases

OBJECTIVE: Systemic inflammatory autoimmune diseases (SIADs) such as systemic lupus erythematosus (SLE), primary Sjögren disease (pSS), and idiopathic inflammatory myopathies (myositis) are complex conditions characterized by shared circulating autoantibodies and clinical manifestations, including skin rashes, among others. This study was aimed at elucidating the genetics underlying these common f

Proximal venous ultrasound with risk stratification safely excludes deep venous thrombosis in emergency department routine care : an observational study

Background: Lower limb deep vein thrombosis (DVT) is common in emergency departments (EDs) and can be fatal if left untreated due to the risk of progression to pulmonary embolism (PE). In Scandinavia, DVT diagnosis typically relies on ultrasound performed outside the ED in the diagnostic departments. However, international guidelines now recommend combining limited/proximal compression ultrasound

Barnets bästa eller vårdnadshavarnas bestämmanderätt? En analys av 6 kap. 13 a § FB vid vårdnadshavares oenighet gällande psykiatrisk vård av barn

I situationer där vårdnadshavare inte är överens om ett barn ska få psykiatrisk utredning eller behandling finns det en möjlighet för socialnämnden att besluta i en vårdnadshavares ställe enligt 6 kap. 13 a § föräldrabalk (1949:381) (FB). Bestämmelsen aktualiseras exempelvis när vårdnadshavare är oense om huruvida ett barn ska utredas eller medicineras mot ADHD. Syftet med bestämmelsen är att till

Governing the Ungovernable: Does the Veto Create a Structural Legal Obstacle in the UN Security Council

Denna uppsats syftar till att undersöka det strukturella problem som uppstår i säkerhetsrådet när rådet hamnar i en rättslig återvändsgränd på grund av ett veto. Uppsatsen utgår från diskussioner kring soft laws påverkan samt användning inom folkrätten och huruvida det kan vara ett användbart instrument för att kringgå sådana rättsliga återvändsgränder. FN-stadgan konstruerades på ett sätt som möjThis essay aims to examine the structural problem that arises in the Security Council when the Council finds itself in a legal impasse due to a veto. The essay is based on discussions on the impact and use of soft law in international law and whether it can be a useful instrument to circumvent such legal impasses. The UN Charter was constructed in a way that allowed for this structural problem bec

Tröskelvärdet för prospektskyldighet - EU:s mål om att underlätta noteringar av värdepapper och Sveriges implementering av ett nytt tröskelvärde

Denna uppsats behandlar EU:s nya regler som förändrar kravet på prospekt - ett detaljerat informationsdokument som företag måste publicera när de erbju-der aktier till allmänheten eller noterar dem på en marknadsplats. Prospektet skyddar investerare genom att ge klar information om företaget, aktierna och riskerna, så att de kan fatta välgrundade beslut. Uppsatsen fokuserar på "tröskelvärdet&This essay discusses how the EU's new regulations change the requirement for prospectus - a detailed information document that companies must publish when offering shares to the public or listing them on a marketplace. The prospectus protects investors by providing clear information about the company, the shares, and the risks, enabling them to make well-informed investments. The essay focuses

För vem gör det ont när utredningen brister? En studie om förvaltningsdomstolars hantering av utredningsbrister inom förvaltningsprocessen

Uppsatsens syfte är att utreda hur en förvaltningsdomstol ska hantera utredningsbrister i förvaltningsmål när en förvaltningsmyndighet har brustit i sitt utredningsansvar. Mot denna bakgrund undersöks vilka handlingsalternativ som står till domstolens förfogande och hur dessa förhåller sig till förvaltningsprocessens funktion och ändamål. Förvaltningsprocessen syftar till att kontrollera förvaltn