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Adult human joint cartilage lesions do not spontaneously heal. Patients with isolated articular cartilage lesions make up perhaps some 1% of the total number of patients examined by arthroscopy. Symptoms such pain and locking, and the suggestion that the untreated lesions may progress to osteoarthritis form the basis for current attempts to repair articular cartilage by cell transplantation and ot

This research is triggered by the emerging ‘power by the hour’® paradigm, in which aero engines are effectively leased to airlines, with the manufacturing company remaining responsible for their maintenance and repair throughout their service life. By incorporating knowledge about the performance of existing products into the design phase of new products, it is hoped to tackle some of the in-servi

Abstract in UndeterminedCaring for intensive care patients involves extensive use ofmedical technology. When staff are educated in workingwith these devices, the focus is on practical management.The context in which they are used is however verycomplex and the device cannot be seen as a separatecomponent. Knowledge about for example the patient’smedical status and background must also be considere

This research was undertaken in an aerospace company, which manufactures aero engines and also offers contracts, under which it remains responsible for the maintenance of engines. These contracts allow the company to collect far more data about the in-service performance of their engines than was previously available. This paper aims at understanding what parts of this in-service information are a

In the chapter the authors revisit one of the original topics in business angel research: to measure the scope of the business angel market and evaluate its impact on the economy, especially the financial contributions of business angels at the macro (market) level. This is an issue that has considerable policy relevance. Most policy initiatives to support business angel activities have been intro

Two emerging diagnostic concepts promote distinct treatments for youth with acute-onset motor abnormalities and severe concurrent psychiatric symptoms: Pediatric acute-onset neuropsychiatric syndrome (PANS) and pediatric catatonia. Both have institutional approval in parts of Europe and in the USA, meriting an unconditional comparison of supporting evidence. Here we report results of qualitative a

Data that defines IGHV (immunoglobulin heavy chain variable) germline gene inference using sequences of IgM-encoding transcriptomes obtained by Illumina MiSeq sequencing technology are described. Such inference is used to establish personalized germline gene sets for in-depth antibody repertoire studies and to detect new antibody germline genes from widely available immunoglobulin-encoding transcr

The paper addresses a puzzle about the proportionality requirement on self-defense due to L. Alexander. Indirectly the puzzle is also relevant to the proportionality requirement on punishment, insofar as the right to punish is derived from the right to self-defense. Alexander argues that there is no proportionality requirement on either self-defense or punishment, as long as the aggressor/offender

Skiljeförfarandet är ett eninstansförfarande som syftar till att snabbt och effektivt åstadkomma en slutlig och bindande skiljedom. Av denna anledning kan en skiljedom inte angripas på materiella grunder. Till skillnad från många utländska skiljeförfarandelagar har en part möjlighet att väcka både ogiltighets- och klandertalan mot skiljedomen som helhet eller i viss del, om skiljenämnden har brustArbitration is a single instance procedure aimed at achieving a final and binding award promptly and efficiently. For this reason, an arbitral award cannot be challenged on substantive grounds. Unlike many foreign arbitration laws, a party may bring an action for invalidity or an action to set aside an arbitral award, in whole or in part, if the arbitral tribunal has failed to comply with procedur

A wideband, compact monopolar patch antenna with an inherent filtering response is presented in this paper. By employing a slot-assisted mode-tailoring technique, the field distributions of several higher-order modes at the patch center are engineered to produce a stable monopolar radiation pattern with enhanced bandwidth. The closed-form analysis indicates that increasing the current intensity at

Policy for science, technology, and innovation is increasingly supporting bottom-up approaches to setting strategic agendas for research and innovation (R&I). These processes are designed to bring industrial needs of R&I intensive sectors to the fore, while at the same time stimulating engagement of other relevant stakeholders, such as public and private research performers. This paper add

Telomerase is expressed in more than 90% of human cancers. Telomere maintenance by this enzyme is believed to safeguard genomic integrity in neoplastic cells. Nevertheless, many telomerase-expressing tumours exhibit chromosomal instability triggered by short, dysfunctional telomeres, implying that active telomerase is not sufficient for preserving a functional telosomic nucleoprotein complex in ca

Expansive cements are utilised in special applications to improve properties such as cracking caused by drying shrinkage. Several types of expansive cements exist and the main hydration product responsible for the expansion is ettringite, [Ca₃Al(OH)₆]₂(SO₄)₃·26H ₂O. The importance of the cement phase containing alumina is well known

Popular Abstract in Swedish Det har nu gått 20 år sedan ett utbrott av ledinflammation (arthrit), i Connecticut, USA, satte forskarna på spåret till den sjukdomsbild som vi idag kallar fästingöverförd borreliainfektion och det är snart 15 år sedan man lyckades isolera bakterien som orsakar sjukdomen, Borrelia burgdorferi. Symptomen på sjukdomen har visserligen varit kända sedan sekelskiftet men he

In humans, each hemisphere comprises an overlay of two visuotopic maps of the contralateral visual field, one from each eye. Is the capacity of the visual cortex limited to these two maps or are plastic mechanisms available to host more maps? We determined the cortical organization of the visual field maps in a rare individual with chiasma hypoplasia, where visual cortex plasticity is challenged t

Splitting the Nash single linear reservoir into two serially connected reservoirs of unequal storage coefficients (one hybrid unit) for a physically realistic response, a hybrid model is introduced for derivation of a synthetic unit hydrograph. Empirical relations are given for estimation of the two storage coefficients from known peak flow (q(p)) and time to peak (t(p)). The hybrid model with two

In order to find the selection rules that can be applied to the electromagnetic transitions when the chiral geometry is achieved, a model for a special configuration in triaxial odd-odd nuclei is constructed which exhibits degenerate chiral bands with a sizable rotation. A quantum number obtained from the invariance of the Hamiltonian is given and the selection rule for electromagnetic transition

A new approach for the classification of patients with Sjogren's syndrome (SS) has been recently proposed. Although these new criteria substantially differ from the American European Consensus Group criteria, which have represented the gold standard for the last decade, when compared with each other the two sets show a high statistical degree of agreement. However, the fact that two different crit