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Aim: Acyl ghrelin increases cardiac output (CO) in heart failure with reduced ejection fraction (HFrEF). This could impair the right ventricular-pulmonary arterial coupling (RVPAC), both through an increased venous return and right ventricular afterload. We aim to investigate if acyl ghrelin increases CO with or without worsening the right-sided haemodynamics in HFrEF assessed by RVPAC. Methods an

Purpose: To report on the ophthalmic findings in children with tuberous sclerosis complex (TSC) in southern Sweden, and to investigate the frequency of refractive errors, strabismus and cerebral visual impairment associated with this condition. Methods: This was a retrospective cohort study including all paediatric patients with TSC in southern Sweden born between 1983 and 2020. Medical records we

Widespread autumn cooling occurred in the northern hemisphere (NH) during the period 2004-2018, primarily due to the strengthening of the Pacific Decadal Oscillation and Siberian High. Yet, while there has been considerable focus on the warming impacts, the effects of natural cooling on autumn leaf senescence and plant productivity have been largely overlooked. This gap in knowledge hinders our un

OBJECTIVES: To correlate femoral neck Hounsfield units (HUs) measured on a computed tomography (CT) scan to dual-energy x-ray absorptiometry (DEXA) T-scores allowing evaluation of bone mineral density (BMD) over time after lower extremity trauma-related amputation.DESIGN: Retrospective cohort study.SETTING: United States military trauma referral center.PATIENTS: Military combat-related lower extre

Background. Pain is common in Parkinson's disease (PD) and impairs quality of life. The King's PD pain questionnaire (KPPQ) is a standardized, reliable, and valid self-administered questionnaire for screening of pain in PD. We developed a linguistically validated German version of the KPPQ and applied it to a cohort with fluctuating PD. Methods. The interculturally adapted German translation was p

Future Internet-of-Things (IoT) systems need to combine heterogeneous IoT components and support weak connectivity. This paper introduces ComPOS, a domain-specific language for composing IoT services into systems. ComPOS is a small language but supports powerful message mediation, using stateful reactions with nested and parallel message sequences and anonymous futures. To deal with weak connectiv

Hollow fibre (HF) membrane modules were applied in continuous mode for equilibrium sampling through membranes (ESTM) of polar organic pollutants. Phenolic compounds (chlorophenols, cresols and phenol) served as model substances and ESTM was tuned towards the measurement of freely dissolved concentrations (C(free)). HF membrane modules were constructed using thin-walled membrane, 1-m module length

BACKGROUND: Internal hernias occur frequently after laparoscopic gastric bypass. We have found no data on the relative strength of the various techniques available for closing these defects. The present study was performed to obtain such data to form a theoretical basis for clinical studies. METHODS: Six piglets were operated laparoscopically and four loops of small bowel created in each. These me

Nanoparticles made from recombinant proteins offer excellent potential for several nanotechnological applications. However, only a very limited number of proteins are currently being used for such purposes due to limited availability and stability. Therefore, we have investigated the enamel matrix protein amelogenin as a new alternative protein for use as recombinant nanoparticles. Amelogenin is a

In common grid installations, services responsible for storing big data chunks, replication of those data and indexing their availability are usually completely decoupled. And a task of synchronizing data is passed to either user-level tools or separate services (like spiders) which are subject to failure and usually cannot perform properly if one of underlying services fails too. The NorduGrid Sm

Wireless Mesh Networks (WMNs) have the potentialities to greatly penetrate the marketplace in the next decade. They can be considered a hybrid between wireless infrastructure and ad-hoc networks; no other network infrastructure is needed other than the mesh points, thus providing flexibility in building and expanding the network, allowing for automatic discovery of neighboring nodes, increased rel

Packaging Logistics is a concept that recognises the need for coordination of the packaging system and its manifold functions throughout a package’s life cycle. Packaging Logistics is an area in need for substantial theoretical building. This dissertation elaborates on its underpinnings and suggests conceptual models that should be useful in better understanding the core of the concept, its undere

Popular AbstractAvhandlingen är en feministisk analys av regionalpolitiken som möjliggörare för kvinnor som vill försörja sig på landbygden som egna företagare. Fokus i studien är kvinnor som ville men inte ansåg sig ha eller fick möjlighet driva sina företagsidéer vidare och därför avvecklade dem på ett tidigt stadium. I intervjuer redogör ett antal kvinnor för sina upplevelser av att arbeta för

The objectives of this study were: (1) to assess nutrient flows and balances at land management systems and cropping seasons levels, and (2) to determine rate of nutrient depletion. The study was conducted in dry lands of Northern Kordofan, Sudan, at El Demokeya Forest Reserve (lat.13° 16′ ′′ ′N; long. 30° 29′ ′′ ′E, and alt. 560 m), over three cropping seasons (2002, 2003 and 2004). Flows and

INTRODUCTION: Sex steroids are important for growth and maintenance of the skeleton. Catechol-O-methyltransferase (COMT) is an estrogen degrading enzyme. The COMT val158met polymorphism results in a 60-75% difference in enzyme activity between the val (high activity=H) and met (low activity=L) variants. We have previously reported that this polymorphism is associated with bone mineral density (BMD

Background: Cellular interactions elicited by Plasmodium falciparum erythrocyte membrane protein antigen 1 (PfEMP1) are brought about by multiple DBL ( Duffy binding like), CIDR ( cysteine-rich interdomain region) and C2 domain types. Elucidation of the functional and structural characteristics of these domains is contingent on the abundant availability of recombinant protein in a soluble form. A

Development of novel disease-modifying treatment strategies for neurological disorders, which at present have no cure, represents a major challenge for today's neurology. Translation of findings from animal models to humans represents an unresolved gap in most of the preclinical studies. Gene therapy is an evolving innovative approach that may prove useful for clinical applications. In animal mode