Small-Molecule Galectin Inhibitors - On Tweezers and Talosides
Abstract Work on the design, synthesis, and biological evaluation of galectin inhibitors is presented. The most significant results relate to the development of galactose-based arginine “tweezers” and taloside-based galectin inhibitors. The galectins are a β-galactoside binding protein family. They are involved in cancer and inflammation, thus comprising interesting pharmaceutical targets. Galact
