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A randomised controlled trial on cross-linking protocols for the treatment of progressive keratoconus using isoosmolar and hypoosmolar riboflavin with the addition of sterile water in thin corneae

Purpose: To present the outcomes of a randomised clinical trial for the treatment of progressive keratoconus using different kinds of riboflavin and the addition of sterile water in thin corneae. Methods: A randomised study using epithelium-off corneal cross-linking (CXL) with continuous UVA irradiance 9 mW/cm2 for 10 min (total fluence 5.4 J/cm2) and two kinds of riboflavin solutions: (i) isoosmo

Hippo in smooth muscle - a therapeutic target in vascular diseases driven by aging and hypertension

Introduction: The Hippo signaling pathway is a key regulator of cellular growth and organ size, acting through the transcriptional coactivators YAP and TAZ. These proteins shuttle between the nucleus and cytoplasm in response to Hippo pathway activity, which, when active, leads to cytoplasmic sequestration and degradation of YAP/TAZ, preventing them from initiating gene transcription. Although ini

Från nyhetsartiklar till algoritmer - En analys av 15 a § URL vid kommersiell GAI-träning med upphovsrättsligt skyddat material

Genom en rättsdogmatisk och rättsanalytisk metod undersöker denna uppsats hur undantaget för text- och datautvinning (TDM) i 15 a § lag (1960:729) om upphovsrätt till litterära och konstnärliga verk (upphovsrättslagen, URL) ska tolkas i relation till träning av generativ artificiell intelligens. Uppsatsen behandlar även huruvida den nuvarande regleringen ger en balanserad avvägning mellan upphovsrUsing a legal dogmatic and legal analytical approach, this thesis examines how the exception for text and data mining (TDM) in section 15a of the Swedish Act (1960:729) on Copyright in Literary and Artistic Works should be interpreted in relation to the training of generative artificial intelligence. It also addresses whether the current regulation provides a balanced trade-off between copyright p

Multiomics assessment of lung adenocarcinoma subtypes defined through tumor purity-adjusted DNA methylation

BackgroundMolecular subtypes of lung adenocarcinoma (LUAD) with varying prognosis and characteristics have been proposed based on one or two-dimensional studies but are not yet implemented into clinical routine. Epigenetic modifications in cancer cells are independent of sequence variants, directly linked to gene and genome regulation, and thus provide important information to guide subclassificat

Testing the personality differentiation by intelligence hypothesis in a representative sample of Swedish hexagenerians

The Personality Differentiation by Intelligence Hypothesis (PDIH) predicts larger trait-variances, and smaller across-trait covariances for individuals with higher intelligence. We tested these predictions using multiple-group confirmatory factor analyses (MG-CFA), while controlling for the potential confound of systematic method variance related to reversed items using a correlated trait, correla

Riskabla samtal – en analys av potentiella faror i skolans kvarts- och utvecklingssamtal

I denna avhandling används samtalsanalys (”conversation analysis”) för att studera ”riskstrategier” i samtal mellan lärare, elever och föräldrar i grundskolan. Materialet består av 80 samtal som insamlats vid två olika tidpunkter: 45 st. inspelade 1992–93 (kvartssamtal, eller den mer formella benämningen enskilda samtal) och ytterligare 35 st. inspelade 2004 (utvecklingssamtal, den benämning som gIn this thesis, conversation analysis (CA) is applied to study “risk strategies” in parent-teacher-student conferences in the Swedish nine-year compulsory school. The material consists of 80 conferences collected at two different points in time: 45 from the period 1992–93 (at that time called kvartssamtal, lit. “quarter of an hour conference”) and another 35 collected in 2004 (at the present time,

Free radicals and brain damage

Although free radicals have been suggested to contribute to ischemic brain damage for more than 10 years, it is not until quite recently that convincing evidence has been presented for their involvement in both sustained and transient ischemia. The hypothesis is examined against current knowledge of free radical chemistry, as it applies to biological systems, and of cellular iron metabolism. It is

Blockwise Classification: Resolving Inconsistencies with Spectral Correction and Hedged Ridge Regression

Image classification systems have been widely applied in smartphones, industrial inspection, and automated devices. However, in real-world scenarios, existing classifiers often produce inconsistent or incorrect predictions due to factors such as image degradation, inter-class similarity, and model instability, thereby reducing the overall performance of the system. To address these issues and enha

Moisture Induced Stress Perpendicular to Grain in Timber Structures

Timber structures and wooden element are in general affected by moisture and moisture variation in different ways. Their hygroscopic properties result in adsorption of water when wetted and in desorption when dried. Because the volume of wood is not constant but varies with the moisture content, uneven distribution of moisture will result in induced eigen-stresses because of internal restraint hyg

The application of resistivity and IP-measurements as investigation tools at contaminated sites : a case study from Kv. Renen 13, Varberg, SW Sweden

Kv. Renen 13 i centrala Varberg är sedan tidigare känt som kraftigt förorenat. På fastigheten har det från slutet av 1800-talet fram till 2003 funnits verksamheter i form av textilindustri som avlösts av finmekanisk verkstadsindustri. Det är framförallt den sistnämnda verksamheten som har orsakat rådande situation med höga halter klorerade lösningsmedel, trikloreten (TCE) och 1,1,1-trikoletan (TCAAn old industry estate, Kv. Renen 13, is located in central Varberg, southwest Sweden, and is known from previous investigations as highly polluted. Pollution started in the late 19th century with textile manufacturing, and in the 1960´s changed into a precision mechanics industry using chlorinated solvents, primary trichloroethene (TCE) and 1,1,1-trichloroethane (TCA), as well as cyanide and meta

Grazing resistance due to trichocysts may boost bloom formation in the HAB species Gonyostomum semen

Popular vetenskapliga sammanfattning: Slemmiga trådar beskyddar blommande alg Att bada i en sjö där algen Gubbslem blommar är ingen trevlig upplevelse. Hur denna art på frammarch har lyckats invadera svenska sjöar förbryllar forskare. En hypotes är att algen försvarar sig med slemmiga trådar som ställer till det för djurplankton som försöker äta den. Den encelliga algen Gubbslem (Gonyostomum sAbstract The harmful algal bloom (HAB) species Gonyostomum semen (Raphidophyceae) has become more frequent in lakes during the past decades and is now referred to as an invasive species. Grazing resistance due to its large size and trichocysts releasing slimy threads has been suggested as a mechanism behind bloom formation in this species. Here, I performed grazing studies with two naturally occu

Vårdnadshavares strikta skadeståndsansvar – en kritisk granskning av ansvaret och dess processrättsliga konsekvenser

Sammanfattning I september 2010 trädde en lagändring i kraft som innebar att vårdnadshavare, utöver sitt redan befintliga tillsynsansvar, blev strikt skadeståndsansansvariga för skador som deras barn vållat genom en brottslig handling. Regleringen ska verka preventivt och minska ungdomsbrottsligheten. Syftet med min uppsats har varit att utreda och kritiskt granska det strikta skadeståndsansvar sSummary In September 2010 an amendment of law was made which meant that legal guardians, in addition to their already existing supervisory responsibility, became subject to strict liability for damages caused by their children through a criminal offence. The aim of the regulation is to decrease juvenile delinquency. The purpose of this thesis is to investigate and critically analyze the strict li

Lagstiftningsprocessen i praktiken - En genomgång av Samordningskansliets betydelse

Sedan hösten 2006 har lagstiftningsprocessen fått ett nytt inslag. Ett oreglerat och nästan okänt inslag, men ack så viktigt. När de fyra borgerliga partierna under åren 2004-2006 förberedde ett eventuellt regeringsskifte efter valet 2006 så var den s.k. Äntringsstyrkans arbete mycket viktigt. Ett av deras viktigaste förslag var att en mekanism för all samordning mellan de fyra partierna skulle inSince fall 2006, the legislative process has a new element. An unregulated and almost unknown element, however very important. When the four center right wing parties during the years 2004-2006 were preparing a possible change of government after the 2006 election, the work of the so-called “Äntringsstyrkan” was very important. One of their main proposals was that a mechanism for all coordination

Nanoscience colloquium 2017 10 02 prof dr gerhard abstreiter lores

Nanoscience_Colloquium_2017_10_02_Prof_Dr_Gerhard_Abstreiter_lores For full program of NanoScience Colloquia see: http://www.nano.lu.se/news-and-events/nanoscience-colloquia NNAANNOOSSCCIIEENNCCEE CCOOLLLLOOQQUUIIUUMM Prof. Dr. Gerhard Abstreiter Thursday November 2, 2017 at 15:15, K-space, Fysicum SSeemmiiccoonndduuccttoorr HHeetteerroo--NNaannoowwiirreess oonn SSii ffoorr PPhhoottoonniicc aanndd

https://www.nano.lu.se/sites/nano.lu.se/files/nanoscience_colloquium_2017_10_02_prof_dr_gerhard_abstreiter_lores.pdf - 2026-04-24

Kravet på ställföreträdare för barn i anknytningsmål - Om barnet i migrationsprocessen och beviskrav för ställföreträdarskap

Familjeåterförening är en viktig princip inom både svensk och internationell rätt. I svensk rätt regleras denna princip i utlänningslagen där en möjlighet till uppehållstillstånd på grund av anknytning ges. Vissa bevisrättsliga frågor måste dock uppfyllas för att uppehållstillstånd ska kunna ges. I denna framställning behandlas bevisning angående ställföreträdarskap för barn som söker uppehållstilFamily reunification is an important principle in both Swedish and international law. In Swedish law this principle is coded into the Aliens Act making it possible to get residence permit on the grounds of ties to Sweden. In order to get a residency permit there are a couple of things you have to prove, for example your identity and the existence of a relation to a person in Sweden. If you are und

Gemensam bostad ur ett företagsperspektiv

De flesta makar och sambor bor tillsammans i en fastighet eller i en lägenhet som de vanligtvis betraktar som deras gemensamma bostad. Inte ovanligt är att fastigheten utgör en lantbruksfastighet eller att någon av parterna bedriver näringsverksamhet i bostaden. För makar och sambor finns i äktenskapsbalken respektive sambolagen ett par skydds¬regler som kan bli tillämpliga vid en separation mellaThe majority of married couples and co-habitants live together in rented or owned accommodation which they usually consider to be their joint property. It is not unusual that the property is an agricultural property or that one half of the couple use the property for business purposes. There are protective provisions in The Marriage Code and also in The Cohabitees Act which are relevant in case of

Hur man särskilt beaktar unga lagöverträdare i straffrättsprocessen

Det straffrättsliga systemet präglas idag av en nyklassisk kriminalpolitik vilken betonar handlingen, handlingens konsekvenser, skulden och brottets svårhet. Dessa faktorer bestämmer straffvärdet vilket medför att de straffrättsliga principerna om bl.a. proportionalitet, förutsebarhet och konsekvens upprätthålls. Straffvärdet som sådant utgör nämligen grunden för påföljdsvalet. Men det finns ytterThe criminal justice system currently emphasizes the action, the consequences of the action, the liability and the gravity of the offense. These factors determine the penalty value, which means that the criminal justice principles such as proportionality, predictability and consistency is maintained. The penalty value as such constitutes the basis when deciding on a suitable penalty. But there are