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Introduction Human breast tumors are heterogeneous and consist of phenotypically diverse cells. Breast cancer cells with a CD44(+)/CD24(-) phenotype have been suggested to have tumor-initiating properties with stem cell-like and invasive features, although it is unclear whether their presence within a tumor has clinical implications. There is also a large heterogeneity between tumors, illustrated
Ernst Wigforss (1881−1977) was Minister of Finance in Sweden 1925−26, 1932−36, and 1936−49, and one of the great ideologists of Swedish SocialDemocracy. During 1918−36 he was also a member of the Chapter in the Diocese of Gothenburg, Church of Sweden.Before 1937, lecturers in the old grammar schools were ex officiomembers of the diocesan chapter. The agnostic Wigforss took his seat in the chapter
The phylogenetic relationship of lecanoroid lichens is studied using two data sets: 1) a 2-locus data set including 251 OTUs representing 150 species, and 2) a 6-locus data set with 82 OTUs representing 53 species. The genus Lecanora as currently circumscribed is shown to be highly polyphyletic and several genera, including Adelolecia, Arctopeltis, Bryonora, Carbonea, Frutidella, Lecidella, Miriqu
Reusing of 3.3 MCM (million cubic meter) of water every year from utilizing thermal water of the hot springs will boost the availability of water at the Dead Sea area. This water represent an additional sources of water for agribusiness in which all available springs and similar sources can follow the same way of successful. In this work the water quality of Afra hot springs was analysed at source
Previous research has not been conclusive regarding the association between selenium (Se) and breast cancer. This study was conducted to clarify if there is an association between prediagnostic serum Se levels and breast cancer risk. A population based cohort, the Malmö Diet and Cancer Study, was used and linked with the Swedish cancer registry up to 31 December 2013. Our study included 1,186 wome
Objective To evaluate the implementation of automated chest compression cardiopulmonary resuscitation (ACC-CPR) after out-of-hospital cardiac arrest (OHCA) in Sweden during the years 2011 through 2015. The association between ACC-CPR and 30-day survival was studied as a secondary objective. Methods The Swedish cardiopulmonary resuscitation registry is a prospectively recorded nationwide registry o
Background:Due to new legislation in 2011 and 2013, the Swedish public healthcare system has undergone change as regards incident reporting and supervision. Focus has turned to learning from adverse events and sharing this learning with actors within the system. The aim of this study was to explore with what underlying safety ontology adverse events in the incident reporting system are investigate
In this talk, model predictive control (MPC) is used to dynamically optimize an investment portfolio. Thepredictive control is based on multi-period forecasts of the mean and covariance of financial returns from amultivariate hidden Markov model with time-varying parameters. Estimation and forecasting are done using anonline expectation--maximization algorithm. There are computational advantages t
In a population-based, matched case-control study from the South Swedish Health Care Region, which has the highest risk for melanoma in Sweden, the relation between the use of sunbeds or sunlamps and malignant melanoma was investigated. Between July 1, 1988, and June 30, 1990, a total of 400 melanoma patients and 640 healthy controls aged 15-75 years answered a comprehensive questionnaire containi
The molecular form and immunochemical properties of the J chain populations released on reduction and carboxymethylation of normal human plasma, milk, saliva and of plasma containing IgA or IgM M-components were investigated. A procedure was devised to release the entire J chain population from these various sources and to produce immunochemically identical J chain populations containing only J ch
The field of molecular phylogenetics is being revolutionized with next-generation sequencing technologies making it possible to sequence large numbers of genomes for non-model organisms ushering us into the era of phylogenomics. The current challenge is no longer how to get enough data, but rather how to analyse the data and how to assess the support for the inferred phylogeny. Here, we focus on o
Introduction: The addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery (CRS) improves recurrence-free (RFS) and overall survival (OS) in patients with FIGO stage III ovarian cancer. We evaluated the effect of HIPEC on patient's health-related quality of life (HRQoL) in the OVHIPEC trial. Materials and methods: OVHIPEC was a multicentre, open-label, random
Climate projections for the 21st century for CMIP6 are warmer than those for CMIP5 despite nominally identical instantaneous radiative forcing. Many climate modeling groups attribute the stronger warming in the CMIP6 projections to the higher climate sensitivity of the new generation of climate models, but here we demonstrate that also changes in the forcing datasets can play an important role, in
This article discusses sustainability in Human Resource Management (HRM) in the blurred digital working life, focusing on the emotion of stress. Its empirical basis is an activity and emotion diary study conducted with 26 employees of three industrial companies in Sweden. Our results show that work and private life are integrated by digital activities and also by emotions. Due to the extensive use
Flexibility of the energy system plays a vital role when integrating non-dispatchable renewable energy technologies. However, flexibility of the energy system has been often discussed only focusing on the operation of the energy system. This study extends the flexibility concept considering both design and operation of the energy system. In order to achieve this, pseudo chronological scenarios use
Human galectins have functionally divergent roles, although most of the members of the galectin family bind weakly to the simple disaccharide lactose (Galss1-4Glc). To assess galectin-glycan interactions in more detail, we explored the binding of several important galectins (Gal-1, Gal-2, and Gal-3) on a glycan microarray containing hundreds of structurally diverse glycans. All three galectins exh
This chapter aims at giving an insight into a variety of available monitoring technologies and techniques, which aim to provide solutions to the issues listed in Chap. 3. First, we start with discussing possible data collection approaches, by revealing choices of available sensors and underlying constrains. Second, we provide a summary of sensors used for data acquisition in regard to needed medic
BACKGROUND: Rare diseases have been continually outlined as one of the causes for the National Health Insurance Fund's (NHIF) deficit spending in Bulgaria.AIM: To estimate the budgetary impact of rare disease medicinal therapies from NHIF perspective for 2014 and 2016.MATERIALS AND METHODS: Budgetary impact of rare diseases is calculated as a percentage of NHIF total pharmaceutical spending. Total
The Biology/Disease-driven (B/D) working groups of the Human Proteome Project are alliances of research groups aimed at developing or improving proteomic tools to support specific biological or disease-related research areas. Here, we describe the activities and progress to date of the B/D working group focused on protein aggregation diseases (PADs). PADs are characterized by the intra- or extrace
