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The aim of this study was to evaluate the efficacy of the new optimised levoclopa, Stalevo(R) (levoclopa, carbidopa and entacapone) in patients with Parkinson's disease experiencing end-of-close wearing-off. Treatment with Stalevo was compared to treatment with traditional immediate-release levodopa and dopa-decarboxylase inhibitor (DDCl) formulations along with adjunct entacapone (Comtess(R)/Comt
Channels were activated, in ripped-off patches from rat-cultured hippocampal neurons, by propofol alone, propofol plus 0.5 muM GABA (gamma-aminobutyric acid) or GABA alone. The propofol-activated currents were chloride-selective, showed outward-rectification and were enhanced by 1 muM diazepam. The maximum propofol-activated channel conductance increased with propofol concentration from less than
model the optimal Bayesian foraging strategy in environments with only two patch qualities. That is, all patches either belong to one rich type, or to one poor type. This has been a situation created in several foraging experiments. In contrast, previous theories of Bayesian foraging have dealt with prey distributions where patches may belong to one out of a large range of qualities (binomial, Poi
This paper examines how organizations for Boy Scouts and Girl Scouts in Sweden dealt with domestic and parental issues, from the movement’s inception in 1910 to 1960. The perspective is twofold. First, it discusses how ideals and expectations concerning participation in domestic matters differed for boys and girls. Were these gender roles stable or changeable? Secondly, it brings to light how pare
The article examines the extent of and factors behind Civil Society Organizations’ (CSOs’) use of social media to influence politics compared with nondigital political strategies, that is, using the traditional media and demonstrations. Taking stock of previous research on information and communication technologies, social media, and political influence, the relevance of four sets of factors is te
During the past 25 years, the combination of increasingly sophisticated gene targeting technology with transplantation techniques has allowed researchers to address a wide array of questions about postnatal mammary gland development. These in turn have significantly contributed to our knowledge of other branched epithelial structures. This review chapter highlights a selection of the mouse models
The devices that constitute the Internet of Things are evolving to include more than just enabling sensing and actuation over a wireless interface. In a contemporary scenario, these devices perform tasks and contribute to an aggregate information flow, in a distributed manner. In the wake of this evolution, new distributed Internet of Things frameworks have emerged. These frameworks maintain a dis
This paper presents a digital hardware implementation of a novel wavelet-based event detector suitable for the next generation of cardiac pacemakers. Significant power savings are achieved by introducing a second operation mode that shuts down 2/3 of the hardware for long time periods when the pacemaker patient is not exposed to noise, while not degrading performance. Due to a 0.13-mu m CMOS techn
The usefulness of measuring neutral lipid fatty acids (NLFAs) and phospholipid fatty acids (PLFAs) separately in order to interpret perturbation effects on soil and compost microorganisms has been studied. Initially the NLFA/PLFA ratios were studied in different soils. Low ratios were found for fatty acids common in bacteria, especially for cyclopropane fatty acids. Higher ratios were found for fa
We explored the potential relationships between male traits, reproductive success, testosterone levels in the breeding season, and Immoral immunocompetence in male red-winged blackbirds (Agelaius phoeniceus). Males responded to a single injection of diphtheriatetanus vaccine by producing antibodies to both antigens. The primary responses to each antigen were positively correlated with each other,
A method to study total deposition of aerosol attached radon progeny in children and adults have been validated and used in home environments. Two persons, one child and one adult are tested simultaneously, thus inhaling from the same aerosol and allowing for a direct comparison. The aim of the study was to increase the knowledge of the lung deposition and thereby the knowledge of the radiation do
As part of the Virus-X Consortium that aims to identify and characterize novel proteins and enzymes from bacteriophages and archaeal viruses, the genes of the putative lytic proteins XepA from Bacillus subtilis prophage PBSX and YomS from prophage SPβ were cloned and the proteins were subsequently produced and functionally characterized. In order to elucidate the role and the molecular mechanism o
The lateral accessory lobes (LALs), paired structures that are homologous among all insect species, have been well studied for their role in pheromone tracking in silkmoths and phonotaxis in crickets, where their outputs have been shown to correlate with observed motor activity. Further studies have shown more generally that the LALs are crucial both for an insect's ability to steer correctly and
Recently, the iterative adaptive approach (IAA) was adopted to allow for the estimation of high-resolution scanning radar images. In this letter, we further develop this approach by introducing a range-recursive IAA (IAA-RR) formulation allowing for a computationally efficient updating of the resulting estimates along range. Besides exploiting the rich matrix structure to mitigate the computationa
Objective To evaluate the implementation of automated chest compression cardiopulmonary resuscitation (ACC-CPR) after out-of-hospital cardiac arrest (OHCA) in Sweden during the years 2011 through 2015. The association between ACC-CPR and 30-day survival was studied as a secondary objective. Methods The Swedish cardiopulmonary resuscitation registry is a prospectively recorded nationwide registry o
Background: Enabling women to make informed decisions is a key objective in the guidelines governing prenatal screening and diagnostics. Despite efforts to provide information, research shows that women's choice of prenatal screening is often not based on informed decisions. The aim of this study was to investigate pregnant women's perceptions of the use of an interactive web-based DA, developed t
Today we can observe an increasing spatial divide as some large urban regions and many more medium-sized and small regions face growing problems such as decreasing labour demand, increasing unemployment and an ageing population. In view of these trends, this book offers a better understanding of the general characteristics and specific drivers of the geographies of growth. It shows how these may v
This paper provides a multi-scalar examination of the Ethiopian coffee sector and its pursuit of climate resilience. Concern is growing about the potential impact of climate change on Arabica coffee in Ethiopia and the 25 million livelihoods it supports. Arabica coffee has a relatively narrow envelope of climatic suitability and recent studies suggest that the area of bioclimatically suitable spac
Purpose: An unprecedented scale of human migration has lead humanitarians to view camps as long-term settlements rather than temporary holding facilities. The purpose of this paper is to increase the understanding of and identify challenges with this proposed new approach to camp design. Design/methodology/approach: Based on the camp design literature, the authors developed an interview guide and
A Swedish/Norwegian head and neck cancer study was designed to assess prospectively the levels of mental distress and psychiatric morbidity in a heterogeneous sample of newly diagnosed head and neck cancer patients. A total of 357 patients were included. The mean age was 63 years, and 72% were males. The patients were asked to answer the HAD scale (the Hospital Anxiety and Depression scale) six ti
