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Popular Abstract in Swedish Bakgrund Den kroniska ögonsjukdomen grön starr (glaukom) skadar ögats synnerv och påverkar den perifera synen (synfältet) hos de som drabbas. I västvärlden är grön starr den näst vanligaste orsaken till blindhet enligt Världshälsoorganisationen WHO. I Sverige räknar man med att cirka 70 000 personer över 70 år har grön starr, men att endast hälften av dessa är kända föThis thesis addresses several aspects of glaucoma diagnostics from both a clinical and a screening perspective. New instruments for diagnosing glaucoma have been developed over the past years, but little information is available regarding their performance as screening methods and their usefulness in ordinary clinical practice. Purpose of the research underlying this thesis The objectives of th

Electron beam optics (particle betatron motion) and trajectory (centroid secular motion) in the FERMI@Elettra free electron laser (FEL) are modeled and experimentally controlled by means of the ELEGANT particle tracking code. This powerful tool, well known to the accelerator community, is here for the first time fully integrated into the Tango-server based high level software of an FEL facility, t

Minimal residual disease (MRD) detection during the early treatment phase has become an important stratification parameter in many childhood acute lymphoblastic leukaemia (ALL) treatment protocols. Here, we aimed to address the applicability of rearranged antigen-receptor genes as potential MRD markers using real-time quantitative polymerase chain reaction (RQ-PCR) in a Swedish population-based co

The aim of this study was to investigate myocardial wall motion using echocardiography and color-coded tissue velocity imaging and to generate a cardiac state diagram for evaluation of the duration of the pre- and post-ejection phases in asphyxiated fetal lambs. Six near-term lambs were partly exteriorized and brought to cardiac arrest through asphyxia. Echocardiography measurements were recorded

This study has two goals: Firstly, to give an account of the semantic organization of individually used antonymic adjectives in discourse, and secondly, based on these finding, and previous work on antonymic meanings, contribute to a comprehensive theoretical account of their representation within the framework of Cognitive Linguistics. The hypothesis is that the members of the pairs are used in t

The IKZF1 gene at 7p12.2 codes for IKAROS (also termed IKZF1), an essential transcription factor in haematopoiesis involved primarily in lymphoid differentiation. Its importance is underlined by the fact that deregulation of IKAROS results in leukaemia in both mice and men. During recent years, constitutional as well as acquired genetic changes of IKZF1 have been associated with human disease. For

BackgroundPrevious studies have reported increased risk of brain tumors after allergic conditions, but no systematic analyses of these tumors in patients with autoimmune disease (AId) have been performed. No data are available on survival among patients with AId from brain tumors. We analyzed systematically risks and survival in histological types of brain tumors among patients who received a diag

The development of a plasmid-based genetic transformation protocol for Chlamydia trachomatis provides the basis for the detailed investigation of the function of the chlamydial plasmid and its individual genes or coding sequences (CDS). In this study we constructed a plasmid vector with CDS6 deleted (pCDS6KO) from the original Escherichia coli/C. trachomatis shuttle vector pGFP::SW2. pCDS6KO was t

Between January 1993 - December 1995, the Galileo spacecraft traversed the interplanetary space between Earth and Jupiter and arrived at Jupiter on 7 December 1995. The dust instrument onboard the spacecraft was operating during most of the time and data from the instrument were obtained via memory readouts which occurred at rates between twice per day and once per week. All events were classified

BACKGROUND: Cardiac surgery places extensive stress on spouses who often are more worried than the patients themselves. Spouses can experience difficult and demanding situations when the partner becomes critically ill. OBJECTIVES: To identify, describe, and conceptualize the individual needs of spouses of patients with complications of heart failure after cardiac surgery. METHODS: Grounded theory

The binaries PSR J1141-6545 and PSR B2303+46 each appear to contain a white dwarf that formed before the neutron star. We describe an evolutionary pathway to produce these two systems. In this scenario, the primary transfers its envelope on to the secondary, which is then the more massive of the two stars, and indeed sufficiently massive later to produce a neutron star via a supernova. The core of

Background: Little is known about the influence of racemic ketamine on autoregulation of cerebral blood flow (CBF), and available reports regarding its influence on cerebral hemodynamics are contradictory. This study was designed to evaluate cerebrovascular responses to changes in the mean arterial pressure (MAP) during ketamine anesthesia. Methods: In eight normoventilated pigs anesthesia was in

BACKGROUND: Diagnosis with prostate cancer has been reported to increase the risk of subsequent tumours. However, specific data on individuals with a parental history are not available so far. METHODS: On the basis of the nationwide Swedish Family-Cancer Database including 18,207 primary invasive prostate cancers, standardised incidence ratios (SIRs) were used to estimate the relative risks of sub

Based on the body of evidence implicating ocular blood flow disturbances in the pathogenesis of glaucoma, there is great interest in the investigation of the effects of antiglaucoma drugs and systemic medications on the various ocular vascular beds. The primary aim of this article was to review the current data available on the effects of antiglaucoma drugs and systemic medications on ocular blood

This experimental study examines the influence of moisture variations on the load-bearing capacity of steel-timber dowel joints. The glulam specimens used to manufacture the joints were first exposed to controlled climate changes. After being stored in the climate chambers, holes were drilled and dowels were inserted. Then, the joints were loaded to failure. The main aim of this study was to inves

This experimental study examines the influence of moisture variations on the load-bearing capacity of steeltimber dowel joints. The glulam specimens used to manufacture the joints were first exposed to controlled climate changes. After being stored in the climate chambers, holes were drilled and dowels were inserted. Then, the joints were loaded to failure. The main aim of this study was to inv

This report presents a project at Lund University Libraries (LUB) during the fall of 2012, with the object to identify areas where the present research support services ought to be developed and strengthened. The project is three folded and contains a) a literature review focusing on definitions and examples of research support services as well as researchers’ needs and experiences of support serv

Popular Abstract in English A handful of diseases-causing pathogenic microorganisms claim millions of lives worldwide each year, mainly due to limited diagnostic capabilities. The lack of simple, cost-effective, sensitive and rapid on-site diagnostic tools lead to delays in the diagnoses with a subsequent lag in treatment, which in turn can result in serious complications or even loss of lives. Fast and sensitive detection of pathogenic microbial cells is a highly important task in medical diagnostics, environmental analysis and evaluation of food safety. Accordingly, the idea of microorganism identification by the recognition of specific DNA sequence using electrochemical technique is one of the leading researches in the development of diagnostic devices. In other words, it should only

The self-pressurization phenomenon is studied numerically with the Volume of Fluid (VOF) method in a cryogenic fluid tank. Heat and mass transfer modelling is used for the phase change calculation at the interface. Transient simulations of the vaporization and pressure rise in a cylindrical liquid hydrogen tank are performed. The computations are carried out by using the CFD software package, Ansy

The usefulness of measuring neutral lipid fatty acids (NLFAs) and phospholipid fatty acids (PLFAs) separately in order to interpret perturbation effects on soil and compost microorganisms has been studied. Initially the NLFA/PLFA ratios were studied in different soils. Low ratios were found for fatty acids common in bacteria, especially for cyclopropane fatty acids. Higher ratios were found for fa