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Ribonucleotide reductase (RNR) is the only source for de novo production of the four deoxyribonucleoside triphosphate (dNTP) building blocks needed for DNA synthesis and repair. It is crucial that these dNTP pools are carefully balanced, since mutation rates increase when dNTP levels are either unbalanced or elevated. RNR is the major player in this homeostasis, and with its four different substra
Background: The slopes of the eastern Andes harbour some of the highest biodiversity on Earth and a high proportion of endemic species. However, there have been only a few and limited descriptions of carbon budgets in tropical montane forest regions. Aims: We present the first comprehensive data on the production, allocation and cycling of carbon for two high elevation (ca. 3000 m) tropical montan
This paper draws attention to a hitherto almost completely neglected encyclopaedic medical handbook composed around 950 CE: al-Muʿālajāt al-Buqrāṭiyya (Hippocratic treatment) attributed to the physician Abū al-Ḥasan Aḥmad b. Muḥammad aṭ-Ṭabarī. The handbook consists of ten books further divided into altogether 473 chapters. Since 1990, the work is available as a facsimile-print published by Sezgin
Popular Abstract in Swedish Inom moralpsykologisk forskning har man framförallt studerat hur människors förmåga att resonera om rättvisa utvecklas i olika åldrar. För de allra flesta av oss är dock moral någonting mer än bara rättvisa. Varje tillfälle då vi bestämmer oss för vad vi tycker är rätt eller fel kan ses som ett moraliskt ställningstagande, från så enkla saker som att man tvekar att gå mPsychological processes involved in moral cognition were examined in three studies, taking as their starting point the assumption that the cognitive-developmental perspective commonly taken is too narrow and that individual differences and implicit processes need to be taken into consideration. Study I focused on the role of defense mechanisms in moral thinking. A self-report questionnaire was co
Popular Abstract in Swedish Malign hypertermi, ärftligt och farligt vid narkos – hur diagnostiseras det ? I april 1960 sövdes en yngling i Australien. Han var mycket orolig därför att tio släktingar dött av eter-narkos. Han sövdes i stället med ett nytt medel – halotan, det höll på att kosta även honom livet. En kortfattad fallbeskrivning i Lancet fick stor uppmärksamhet och på andra ställen i väMalignant hyperthermia (MH) susceptibility is a rare inherited muscular disorder, which may cause a lethal increase in metabolism during anaesthesia with certain commonly used anaesthetic. Susceptible individuals are without any signs or symptoms. It is important to identify individuals at risk, since the MH reaction is preventable. Susceptibility to MH is diagnosed with an in vitro contracture te
Popular Abstract in Swedish Malmö erbjuder speciellt goda möjligheter till epidemiologiska studier, därför att all sjukhusbunden vård erbjuds av ett enda sjukhus som dessutom i stort sett endast täcker Malmös egna behov. Därtill kommer att nu avlidne professor Folke Linell redan under 1950-talet insåg den stora betydelsen för sjukvårdens kvalitet av en omfattande obduktionsverksamhet. Under periodIn the present thesis incidence, survival, mortality, cure and prognosis in invasive breast cancer in Malmö was studied over a 30 year period. Validated data from the Cancer Registry and the Cause of Death Registry were used. In the process of validation systematical biases were identified in both registers. The incidence increased over time and was strongly related to increases in diagnostic acti
Aim. The purpose of this investigation was to analyze predictors for wound healing, amputation and mortality after vacuum assisted closure (VAC (R)) therapy of wounds in the lower limb in patients with arterial disease. Methods. One hundred and twenty one wounds were treated and followed for 12 months at two vascular centres in Uppsala and Malmo, Sweden. VAC (R) therapy was applied in the wound at
To examine a putative role for neuronal nitric oxide synthase (nNOS) in early vertebrate development we investigated nNOS mRNA expression and cGMP production during development of the zebrafish Danio rerio. The nNOS mRNA expression in the central nervous system (CNS) and periphery showed a distinct spatio-temporal pattern in developing zebrafish embryo and young larvae. nNOS mRNA expression was fi
We report the isolation and characterization of a cDNA encoding the mitochondrial short chain DELTA-3,DELTA-2-enoyl-CoA isomerase from rat liver. Tryptic fragments of the purified protein were generated, purified, and sequenced. A rat liver cDNA library, constructed in the plasmid vector pUEX1 was screened with oligonucleotides synthesized on the basis of peptide sequences. The obtained clone cont
BACKGROUND: The planning target volume in radiotherapy treatment planning takes into account both movements of the clinical target volume (CTV) and set-up deviations. MATERIALS AND METHODS: A group of patients who received radiotherapy for lung cancer were studied. In order to measure the CTV movements due to respiration and other internal organ motions, fluoroscopy was performed for 20 patients.
For unknown reasons, there is a greater increase in the risk for cardiovascular complications in diabetic women than in diabetic men. Our aim was to study gender-related differences in the mechanical properties of the great arteries in patients with insulin-dependent diabetes mellitus (IDDM) but free from known cardiovascular and cerebrovascular complications. We measured arterial stiffness (beta,
This study aimed to characterize the ST-recovery loop and assess which range of heart rates (HRs) best discriminates between patients with and without significant coronary artery stenosis. Bicycle exercise tests were undertaken in 44 men and IS women with coronary artery disease (CAD) and in 59 controls (26 men, 33 women) in the same age range with no signs of CAD. The ST level and the ST-segment
X-linked retinitis pigmentosa (XLRP) is a severe form of inherited progressive retinal degeneration. The RP3 (retinitis pigmentosa type 3) locus at Xp21.1 is believed to account for the disease in the majority of XLRP families. Linkage analysis and identification of patients with chromosomal deletion have refined the location of the RP3 locus and recently have led to the cloning of the RPGR (retin
Parser generators are an indispensable tool for rapid language devel- opment. However, they often fall short of the finesse of a hand-crafted parser, built with the language semantics in mind. One area where generated parsers have pro- vided unsatisfactory results is that of error recovery. Good error recovery is both natural, giving recovery suggestions in line with the intention of the programme
Background: Allergic contact dermatitis from glucose sensors may interfere with their ongoing application. Objective: To evaluate a series of Spanish patients with contact dermatitis to glucose sensors regarding former sources of contact allergens, patch test results, and outcomes from the ongoing use of the device. Methods: A series of patients with contact dermatitis from glucose sensors was inv
Objective: Infliximab-treated patients with rheumatoid arthritis (RA) may respond insufficiently due to low serum infliximab (sIFX) levels, caused by anti-drug antibodies (ADAs). However, monitoring of sIFX and ADAs is not routinely implemented, and levels for optimal outcome have not been validated. We searched for predictors for sIFX < 0.2 μg/mL and ADA development in a randomized setting. Metho
Background: Overweight and obesity were recently associated with a poor prognosis in patients with autosomal dominant polycystic kidney disease (ADPKD). Whether the metabolic consequences of obesity as defined by the metabolic syndrome (MS) are also linked with disease progression remains untested. Methods: Eligible ADPKD patients with different stages of CKD (n = 105) and 105 non-diabetic control
BACKGROUND AND OBJECTIVES: Kidd blood group system consists of two major antigens: Jka and Jkb . Both the antigens are absent in individuals typed as Jknull and may develop clinically significant anti-Jk3 antibody. Screening donors for provision of Jknull blood is an ongoing task for blood centres with Jknull blood units kept frozen for specific requirements. In 2016, we discovered a previously ty
In this thesis, I have studied when an initially monomorphic population can diverge into two morphs in a heterogeneous environment. Evolution is driven by competition for resources or predation. In Paper I, we studied source-sink dynamics during evolution in an environment with two types of resource of different abundance in two habitats. We found that dispersal can help maintain higher diversity
Osteoarthritis (OA) is the most common form of arthritis and often causes pain and functional impairment. Despite its high burden on society, knowledge about the occurrence of OA and its associated mortality is sparse. The epidemiology of OA is difficult to determine due to the patients’ fluctuating symptoms and challenges in detecting and defining the radiographic disease. The specific aims of th
