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Exploring the Effects of Deep Brain Stimulation and Vision on Tremor in Parkinson's Disease : Benefits from Objective Methods

BACKGROUND: Tremor is a cardinal symptom of Parkinson's disease (PD) that may cause severe disability. As such, objective methods to determine the exact characteristics of the tremor may improve the evaluation of therapy. This methodology study aims to validate the utility of two objective technical methods of recording Parkinsonian tremor and evaluate their ability to determine the effects of Dee

Early Paleogene biosiliceous sedimentation in the Atlantic Ocean : Testing the inorganic origin hypothesis for Paleocene and Eocene chert and porcellanite

The widespread occurrence of lower Eocene chert and porcellanite has been viewed as a major paleoceanographic issue since the advent of ocean drilling, and both biotic and abiotic forcings have been proposed to explain it. We present a reconstruction of indurated siliceous sediment (ISS) and preserved biosiliceous sediment (PBS) occurrences in the Atlantic Ocean through the Paleocene and Eocene (~

Differences in incubation behaviour and niche separation of two competing flycatcher species

Abstract: Food availability sets the stage for incubation behaviour of a female bird and thereby indirectly determines the nest temperature, which in turn affects development and metabolism of avian embryos. Changes in development and metabolism in turn are known to influence offspring’s ability to adjust to environmental changes later in life. However, few studies have investigated the role of in

Combining dense and sparse labeling in optical DNA mapping

Optical DNA mapping (ODM) is based on fluorescent labeling, stretching and imaging of single DNA molecules to obtain sequence-specific fluorescence profiles, DNA barcodes. These barcodes can be mapped to theoretical counterparts obtained from DNA reference sequences, which in turn allow for DNA identification in complex samples and for detecting structural changes in individual DNA molecules. Ther

Plateaus and jumps in the atmospheric radiocarbon record - Potential origin and value as global age markers for glacial-to-deglacial paleoceanography, a synthesis

Changes in the geometry of ocean meridional overturning circulation (MOC) are crucial in controlling past changes of climate and the carbon inventory of the atmosphere. However, the accurate timing and global correlation of short-term glacial-to-deglacial changes of MOC in different ocean basins still present a major challenge. The fine structure of jumps and plateaus in atmospheric and planktic r

Two-Substrate Glyoxalase i Mechanism : A Quantum Mechanics/Molecular Mechanics Study

Glyoxalase I (GlxI) is an important enzyme that catalyzes the detoxification of methylglyoxal (MG) with the help of glutathione (H-SG). It is currently unclear whether MG and H-SG are substrates of GlxI or whether the enzyme processes hemithioacetal (HTA), which is nonenzymatically formed from MG and H-SG. Most previous studies have concentrated on the latter mechanism. Here, we study the two-subs

Structures of subcontracting : Work organisation, control, and labour in the Swedish building sector

Svensk byggindustri är under förändring. Stora delar av produktionen läggs idag ut på entreprenad och byggföretag förlitar sig på underentreprenörer i större utsträckning än tidigare. Som en del av en global trend av kostnadsreducering inom byggindustrin, försöker byggföretag minimera antalet anställda hantverkare och istället utkontraktera arbete till underentreprenörer i strävan efter organisatoThe organisation of work in the Swedish building sector is changing due to increased subcontracting and the adoption of construction management. In this study, construction management refers to a specific subcontracting regime, in which contractors externalise all parts of the production process and organise work through subcontractors. Echoing global trends of cost-cutting, this externalisation b

A combined fracture and mortality risk index useful for treatment stratification in hip fragility fractures

Objectives: In this study, we aimed to assess the stratification ability of the Fracture and Mortality Risk Evaluation (FAME) index for reoperation, new fragility fracture, and mortality during one-year follow-up. Patients and methods: Between November 2018 and July 2019, a total of 94 consecutive hip fragility fracture patients from two centers (20 males, 74 females; mean age: 79.3±8.9 years; ran

Bottom-water oxygenation and environmental change in Santa Monica Basin, Southern California during the last 23kyr

The Southern California Borderland is a region that experiences strong natural variations in bottom water oxygen and pH. We use marine sediments from Santa Monica Basin to reconstruct environmental conditions in the basin's bottom water from the Last Glacial Maximum (LGM) to present. We then compare the records to the adjacent Santa Barbara Basin and Santa Lucia Slope. High-resolution records of b

Critical biomass harvesting – Applying a new concept for Swedish forest soils

The contribution of forest harvesting to base cation losses and soil acidification has increased in recent years in Sweden, as the demand for bioenergy has increased and the sulphur deposition has decreased. Thus, new policy tools are required to evaluate the progress of the recovery from acidification, and as a basis for forest management recommendations. In this study we introduce and test a con

Hormone Sensitive Lipase - in vitro phosphorylation

Abstract Fatty acids mobilized from triacylglycerol stores are a major energy source in humans. Mobilization occurs through the consecutive action of three lipases: adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL) and monoglyceride lipase (MGL). Whereas ATGL and MGL only hydrolyse tri- and monoacylglycerols, respectively, HSL has a broad substrate range and hydrolyses cholesterol

Use of neural progenitor cell lines and astrocytes for transplantation and gene transfer to the CNS.

Popular Abstract in Swedish Transplantation av nervvävnad till hjärnan är inte en ny idé. Redan 1890, publiserade Thompson de första försöken att transplantera vuxen hjärnvävnad till det vuxna centrala nervsystemet och han rapporterade att vävnaden överlevde i sju veckor "without wholly losing its identity". Trots detta var det först under 1970-talet som metoderna för intracerebral nervcellstranspIntracerebral neuronal transplantation have been shown to ameliorate symptoms of brain dysfunction in both animals models and Parkinson's disease, although problems still remain. The newly introduced technique of ex vivo gene transfer could serve as an alternative approach, possible avoiding some of the draw-backs of the embryonal tissue used in neuronal grafting. We have investigated the feasibli

Encapsulation of sugar beet phytoglobin BvPgb 1.2 and myoglobin in a lipid sponge phase system

Globins are usually associated with oxygen carriage in vertebrates. However, plants also contain similar heme-containing proteins, called phytoglobins (Pgbs). Unlike conventional hemoglobin, these proteins are often linked to nitric oxide metabolism, energy metabolism and redox maintenance under hypoxic and related abiotic and biotic stress conditions. Class I and II non-symbiotic Pgbs (nsPgbs) ha

Exploring the impacts of unprecedented climate extremes on forest ecosystems : Hypotheses to guide modeling and experimental studies

Climatic extreme events are expected to occur more frequently in the future, increasing the likelihood of unprecedented climate extremes (UCEs) or record-breaking events. UCEs, such as extreme heatwaves and droughts, substantially affect ecosystem stability and carbon cycling by increasing plant mortality and delaying ecosystem recovery. Quantitative knowledge of such effects is limited due to the

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Omtentamen grundkurs, delkurs 3 Senmedeltid och tidigmodern tid HT2024 10 januari 2025 8:00-13:00 (LUX B336) Läs detta noga innan du skriver tentan 1. Du ska besvara de nedanstående frågorna: 3 essäfrågor och 12 korta frågor. 2. Inga hjälpmedel är tillåtna. 3. Läs frågan noggrant minst 2 gånger innan du börjar besvara den. 4. Skriv allt du kan som är relevant för frågeställningen. Svaren ska inte

https://www.hist.lu.se/fileadmin/user_upload/historiska/hist/Historia/dokument_utb_Hist/Extentor/Extentor_Senmedeltid.pdf - 2026-06-22

Acquisition model for small privately held manufacturing businesses in the United Kingdom

Issue of study: The plastic injection moulding industry has become highly competitive in terms of lead times and pricing, following an increase in low-cost manufacturing from Asia, as a part of the full supply chain. To remain competitive, mould tool manufacturers are looking to complement new tool manufacturing with local after-sales services in countries where their mould tools are being used. U

Know-who? Know-what? Know-how? : investigating learning in a multi-actor partnership for urban freight transport in the city of Gothenburg

People’s ability to learn holds a promise for sustainability as learning is seen to enable change; yet, the prevalence of norms and values in society that reinforce unsustainability may severely challenge this process. The debate on what role learning can play is centered around the question whether people can learn from others and if so, how to enhance it. More precisely, who has to learn what fr

Finding The Women's Voice

“There is no tool for development more effective than the empowerment of women,” Kofi Annan (UN News Center, 2005). The empowerment of women takes different forms such as pursuit of education, participation in political activities and representation in leadership, equal employment opportunities and wages, access to health care and ability to make decisions on personal reproductive health, economic

Modelling of nitrous oxide emissions from clover grass ley : wheat crop rotations in central eastern Germany : an application of DNDC

Nitrous oxide (N2O) is one of the three primary anthropogenic greenhouse gases. The agricultural sector accounts for 75.7 % of all anthropogenic N2O emissions in Germany (Umweltbundesamt, 2012). Thus, accurately estimating N2O emissions as well as mitigation strategies for N2O are crucial. This study optimizes the process-based model DNDC to simulate N2O emissions by conventional winter wheat and