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BACKGROUND: Fever is associated with brain injury after cardiac arrest. It is unknown whether fever management with a feedback-controlled device impacts patient-centered outcomes in cardiac arrest patients. This trial aims to investigate fever management with or without a temperature control device after out-of-hospital cardiac arrest. METHODS: The TEMP-CARE trial is part of the 2 × 2 × 2 factoria

Background: In patients resuscitated after cardiac arrest, a higher mean arterial pressure (MAP) may increase cerebral perfusion and attenuate hypoxic brain injury. Here we present the protocol of the mean arterial pressure after cardiac arrest and resuscitation (MAP-CARE) trial aiming to investigate the influence of MAP targets on patient outcomes. Methods: MAP-CARE is one component of the Sedati

Microbial contamination in coastal environments and groundwater is explored within this thesis, focusing onfecal contamination from anthropogenic sources and microbial community dynamics. The spread andpersistence of microbial contaminants in complex aquatic environments with multiple intermittent and pointsources of contamination, was studied in order to lay a groundwork for developing more robus

Background and objective: Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is an evolving diagnostic tool for prostate cancer. There is a need to harmonise existing guidelines and reporting recommendations for PSMA PET/CT. The Standardised PSMA PET/CT Analysis and Reporting Consensus (SPARC) project aims to consolidate classifications and recommen

OBJECTIVES: The Sepsis-3 definition states the clinical criteria for sepsis but lacks clear definitions of the underlying infection. To address the lack of applicable definitions of infection for sepsis research, we propose new criteria, termed the Linder-Mellhammar criteria of infection (LMCI). The aim of this study was to validate these new infection criteria.DESIGN: A multicenter cohort study o

Fine-grained windblown deposits (loess) in which fossil soils (palaeosols) are preserved are excellent records of past climate. However, so far paleoclimate reconstruction studies conducted on such loess-palaeosol sequences (LPS) in SE Europe were focused on the climate changes of the last one or two glacial-interglacial cycles, while almost no attention has been directed to the climate of the cur

IntroductionAlthough Chronic Obstructive Pulmonary Disease (COPD) is generally considered a progressive condition with limited reversibility, recent data suggests potential for lung function improvement with exercise. Mechanistic insights into exercise-induced benefits remain limited, but in vitro models offer promise for understanding cellular and molecular changes. This study aims to elucidate t

Both phosphoryl and sulfuryl transfers are ubiquitous in biology, being involved in a wide range of processes, ranging from cell division to apoptosis. Additionally, it is becoming increasingly clear that enzymes that can catalyze phosphoryl transfer can often cross-catalyze sulfuryl transfer (and vice versa). However, while there have been extensive experimental and theoretical studies performed

Mapping in situ eddy covariance measurements of terrestrial land–atmosphere fluxes to the globe is a key method for diagnosing the Earth system from a data-driven perspective. We describe the first global products (called X-BASE) from a newly implemented upscaling framework, FLUXCOM-X, representing an advancement from the previous generation of FLUXCOM products in terms of flexibility and technica

Background: Metabolic syndrome (MetS) is characterized by coexisting risk factors for type 2 diabetes and cardiovascular disease. Diet is of importance in their aetiology, and gut microbiota (GM) may constitute a link between diet and metabolic health. Understanding the interplay between diet and GM could contribute novel insights for future dietary guidelines, and aid in preventive actions to mot

Association studies were carried out on a sample of 87 patients from Sweden who had survived a myocardial infarction (MI) at a young age and 93 age-matched healthy individuals, to compare the impact of polymorphisms (PvuII, HindIII and Serine447-Stop) at the lipoprotein lipase (LPL) gene locus on among-individual differences in plasma lipid traits and progression of atherosclerosis. Significant li

The bird-lemming hypothesis postulates that breeding success of tundra-nesting geese and waders in Siberia follows the cyclic pattern of lemming populations, as a result of predators switching from lemmings to birds when the lemming, population crashes. We present 50 years of data on constant-effort catches of red knot Calidris canutus and curlew sandpiper C. ferruginea at an autumn migratory stop

1 LÄRANDE I LTH Detta nummer av Lärande i LTH innehåller två artiklar, som på ett sätt kompletterar varandra, samtidigt som de är skrivna helt åtskilda och med olika innehåll. Den första artikeln är skriven av en lärare vid Filosofiska institutionen, som beskriver lärandetrösklar hos kursdeltagare som inte förväntar sig inslag av matematik och logik i strikt mening inom ramen för en kurs vid Human

https://www.lth.se/fileadmin/cee/genombrottet/Laerande_i_LTH/La__rande_i_LTH_blad_33.pdf - 2026-06-07

BACKGROUND: Tremor is a cardinal symptom of Parkinson's disease (PD) that may cause severe disability. As such, objective methods to determine the exact characteristics of the tremor may improve the evaluation of therapy. This methodology study aims to validate the utility of two objective technical methods of recording Parkinsonian tremor and evaluate their ability to determine the effects of Dee

The widespread occurrence of lower Eocene chert and porcellanite has been viewed as a major paleoceanographic issue since the advent of ocean drilling, and both biotic and abiotic forcings have been proposed to explain it. We present a reconstruction of indurated siliceous sediment (ISS) and preserved biosiliceous sediment (PBS) occurrences in the Atlantic Ocean through the Paleocene and Eocene (~

Abstract: Food availability sets the stage for incubation behaviour of a female bird and thereby indirectly determines the nest temperature, which in turn affects development and metabolism of avian embryos. Changes in development and metabolism in turn are known to influence offspring’s ability to adjust to environmental changes later in life. However, few studies have investigated the role of in

Popular Abstract in Swedish Det finns många skäl till varför streptomyceter är en intressant grupp av bakterier att undersöka. Den här avhandlingen fokuserar på celldifferentieringen hos dessa organismer och deras förmåga att bilda en specialiserad typ av tåliga celler som kallas sporer. Genom att studera sporuleringsprocessen hos dessa bakterier kan man lära sig mycket om fundamentala livsprocessStreptomycetes are Gram-positive bacteria with a complex developmental life cycle. They form spores on specialized cells called aerial hyphae, and this sporulation involves alterations in growth, morphogenesis and cell cycle processes like cell division and chromosome segregation. Understanding the developmental mechanisms that streptomycetes have evolved for regulating for example cell division i

Popular Abstract in Swedish De generella företeelser som sker i samband med en axonal skada i det perifera nervsystemet (PNS) har tidigare beskrivits i detalj. Däremot är de molekylära mekanismer som ligger bakom celldöd, eller bakom nervcellens förmåga att regenerera efter en axonal skada, ringa studerade. Den här avhandlingen behandlar en sådan molekylär mekanism, JNK-medierad aktivering av c-JuThe events associated with axonal injury in the peripheral nervous system (PNS) have been described in detail. However, the molecular mechanisms underlying the regenerative response, or neuronal cell death, following axonal injury are poorly understood. This thesis concerns one such molecular mechanism, JNK-mediated c-Jun activation, in peripheral sensory and sympathetic neurons. By immunohistoche