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This work aimed to characterize single chain fragment variables (scFvs) against S100A7 and Calprotectin, proteins part of the Ca2+ binding S100 family that have been associated with inflammatory diseases and cancer. The mechanisms governing the physiological functions of S100 proteins are not fully understood, but it is known that many of them contribute to maintaining homeostasis in the intracell
Freshwater systems are active components of the global carbon cycle and contribute to global CO2 emissions. Freshwater studies in the Arctic are underrepresented, especially regarding lakes and their Dissolved Organic Carbon (DOC) reactivity and composition dynamics. DOC is a main part of DOM (dissolved organic matter), which drives processes central to carbon cycling, influences chemical and biol
Non-fungible tokens (NFTs) are a type of cryptocurrency that consist of unique, non-exchangeable tokens, which are traded on a blockchain. These unique tokens are associated with digital assets such as images, art, videos, or music. With the rapid rise of NFTs’ popularity in 2021, a community established around trading, selling, and collecting of NFTs. This study explored the NFT community at larg
Populärvetenskaplig sammanfattning av examensarbete utfört vid institutionen för byggvetenskaper vid LTH i samarbete med Sweco Civil AB. Under vissa förhållanden kan sugkrafter uppstå i jord. Fenomenet är sammankopplat med hur mycket vatten det finns i marken, desto mindre vatten desto högre sugkraft och därmed mindre risk för att t.ex. jordslänter rasar. För att undersöka detta fenomen har finiIn this master´s dissertation I investigated if it is possible to increase the total stability for excavations in clay, if suction is taken into account during the calculations. The work has been performed at, and in cooperation with, Sweco Civil AB as well as the Dept. of Construction Sciences at Faculty of Engineering LTH, Lund University. The objective of this master´s dissertation is to asse
With millions of yearly beach visitors in southern California, beach water quality represents an important factor in public health and ocean dependent economy. Fecal indicator bacteria (FIB) in water is much easier to measure than disease causing organisms but correlation exists between the two. For this reason, FIB concentrations are used to measure recreational water quality and related health r
Tunnelling below water passages is a challenging task in terms of planning, pre-investigation and construction. Fracture zones in the underlying bedrock lead to low rock quality and thus reduced stability. For natural reasons, they tend to be more frequent at water passages. Ground investigations that provide information on the subsurface are necessary prior to the construction phase, but these ca
The accurate diagnosis of malaria is crucial for ensuring an effective treatment and combating the developing drug resistance of the parasite. The standard diagnostic method, consisting of light microscopy in combination with Giemsa-staining, requires manual examination through a trained clinician. This is time-consuming and prone to human error. While emerging diagnostic innovations can overcome
Understanding the dynamic of a population via either abundance or density is crucial for wildlife conservation. The brown bear (Ursus arctos) is a commonly distributed, yet elusive species, playing a major role in the ecosystem. Usually monitored with genetic sampling, hunted bags, or telemetry data, the use of camera traps for bear monitoring is still to this day a rarely used, yet promising meth
As climate change and unsustainable waste practices present major global challenges, effective waste management in developing countries becomes critically important. In South Africa, organic waste constitutes a significant share of general waste and is often landfilled, contributing to methane emissions and serious health risks for the population. In response, the Western Cape province has introdu
Head and neck squamous cell carcinoma (HNSCC) is a heterogenous cancer with poor prognosis, especially for patients with advanced or recurrent disease. The complex tumor microenvironment (TME) plays an important role in mediating immune evasion and therapy resistance. To improve preclinical testing, advanced 3D in vitro and ex vivo models such as spheroids, organoids, and tumor slice cultures have
Background and objective: We established prognostic nomograms incorporating prostate-specific membrane antigen (PSMA) positron emission tomography (PET) parameters standardised by Prostate Cancer Molecular Imaging Standardized Evaluation (PROMISE; PPP1). Here, we develop an updated PPP2 risk score from a large international multicentre registry study. Methods: We included 6128 prostate cancer pati
Solpaneler på taket är numera en vanlig syn, men vart tar elen vägen när solen skiner som mest? I detta examensarbete har det undersökts hur flerbostadshus kan använda egna batterier för att spara pengar, bli mer självförsörjande och samtidigt stötta elsystemet. Svaret är att batterier kan löna sig, om de används smart. När elnätet blir allt mer pressat och produktionen från förnybar energi varierThis thesis examines the economic potential of lithium-ion battery storage systems in multi-family residential buildings in Sweden, focusing on profitability, revenue opportunities, and the factors influencing investment decisions. The increasing share of renewable electricity, combined with the electrification of society, has intensified the need for energy storage solutions capable of balancing
Importance: The ability to predict sudden cardiac death (SCD) in children and adolescents with hypertrophic cardiomyopathy (HCM) is currently inadequate. Late gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR) imaging is associated with SCD events in adults with HCM. Objective: To examine the prognostic significance of LGE in patients with HCM who are younger than 21 years. De
Throughout history, human civilisation and wildlife have instinctively settled close to water and coastlines out of necessity for resources. It has always been a natural instinct, yet we have also continually adapted to weather conditions and relocated when resources were found elsewhere. We have always been flexible and mobile, adapting to nature and allowing it to lead and guide us. With the ris
Saccharomyces cerevisiae: Genome editing and investigation of the peroxisome & beta-oxidation For thousands of years humans have used yeast to brew beer, bake bread and make wine. Nowadays, these microorganisms can be used to produce various chemicals and proteins. One interesting compound is capsaicin, found in the chili pepper plant and commonly used in food, but lesser-known for its applic
GPS tracking technologies are essential to follow long-distance migratory species throughout their annual cycle and identify the threats they encounter at large geographical scales. Information on the “lost” years of juvenile individuals of many species is lacking and it is vital to uncover their movements during these critical early stages. The Baltic Lesser Black-backed Gull (L. f. fuscus), a lo
The PResymptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) is an investigator-driven study that was created in 2011 and enrolled cognitively normal older adults with a family history of sporadic AD. Participants are deeply phenotyped and have now been followed annually for more than 12 years (median follow-up 8.0 years, SD 3.1). Multimodal magnetic reson
Background: The benefit of surgical resection for colorectal cancer (CRC) lung metastases is unclear. The aim was to investigate the incidence, treatment strategy, and 5-year overall survival (OS) in CRC patients with isolated lung metastases. Methods: This registry-based retrospective cohort study included patients treated with curative resection of CRC within the county of Skåne during the perio
Uppsatsen behandlar hur miljörelaterade fordringar hanteras när en verksamhet går i konkurs och i vilken utsträckning principen om att förorenaren ska betala får genomslag i svensk konkursrätt. Utgångspunkten är de praktiska problem som uppstår när kostsamma efterbehandlingsåtgärder aktualiseras först efter konkursutbrottet, samtidigt som det inte finns någon generell skyldighet för staten eller kThis thesis examines how environmental claims are treated when a business is declared bankrupt, and to what extent the polluter pays principle is upheld in Swedish bankruptcy law. The point of departure is the practical difficulties that occur when costly remediation measures become relevant only after the opening of bankruptcy proceedings, while there is no general legal obligation for the State
BACKGROUND: – Proteins linked to heritable coronary heart disease (CHD) could uncover new pathophysiological mechanisms of atherosclerosis. We report on the protein profile associated with a family history of early-onset CHD and whether the relation between proteins and coronary atherosclerotic burden differs according to family history status, as well as inferences from Mendelian randomization. M
