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Scientific summary: Ground settlement due to groundwater drainage during construction is important to be considered since ground settlement may cause severe building damages. The calculation of ground settlement contained several parameters with different magnitude of uncertainties. Thus a risk evaluation of ground settlement is necessary. The aim of this thesis was first to build a soil strata mo
Aim: The primary aim was to compare the 30-day morbidity and mortality in patients aged ≥80 years undergoing surgery for colorectal cancer with those aged <80 years. The secondary aim was to identify independent outcome predictors. Method: This was a retrospective study of patients undergoing surgery for colorectal cancer between January 2007 and February 2018. Patients were divided into those <80
Some polycyclic aromatic hydrocarbons (PAH) are known carcinogens and workplace PAH exposure may increase the risk of cancer. Monitoring early cancer-related changes can indicate whether the exposure is carcinogenic. Here, we enrolled 151 chimney sweeps, 152 controls, and 19 creosote-exposed male workers from Sweden. We measured urinary PAH metabolites using LC/MS/MS, the cancer-related markers te
Popular Abstract in Swedish Som en följd av de senaste årens förtätningstrend har stadens täthet blivit en aktuell stadsbyggnadsfråga. Förtätning är ett komplext fenomen som berör en rad centrala egenskaper hos staden. Förtätning är också en kontroversiell stadsbyggnadsstrategi. Det är motsättningen mellan förtätning och friytor som den här avhandlingen tar sin utgångspunkt i. Krymper mellanrummenThe new interest in density displayed by professional town planners and town-planning researchers is related to the present densification of the urban environment in many towns and cities. Research on densification is primarily concerned with the link between urban form and sustainable development. The point of departure of this thesis is to consider what a denser housing environment will mean to
Objectives To identify the genetic determinants of fracture risk and assess the role of 15 clinical risk factors on osteoporotic fracture risk. Design Meta-analysis of genome wide association studies (GWAS) and a two-sample mendelian randomisation approach. Setting 25 cohorts from Europe, United States, east Asia, and Australia with genome wide genotyping and fracture data. Participants A discover
OBJECTIVE: Resistance to androgens has been suggested as a possible cause of male infertility. This hypothesis is based mainly on binding studies in genital skin fibroblasts but the molecular evidence is sparse. DESIGN: Molecular studies of the androgen receptor gene were performed in 10 azoo- or oligozoospermic men, precenting with clinical signs of low androgen activity - poor virilization and h
An extended version of a numerical model introduced by Larson et al. (2013) to simulate long-term cross shore material exchange for the subaqueous portion of the profile has been developed. Efforts have focused on improving the model to better account for beach systems consisting of two bars (inner and outer bar), as well as simulating the feeder response over time of nearshore dredged material ba
PURPOSE: The R2Pulm trial was conducted to evaluate the effect of busulfan-melphalan high-dose chemotherapy with autologous stem-cell rescue (BuMel) without whole-lung irradiation (WLI) on event-free survival (main end point) and overall survival, compared with standard chemotherapy with WLI in Ewing sarcoma (ES) presenting with pulmonary and/or pleural metastases. METHODS: From 2000 to 2015, we e
Accurately quantifying soil base cation pool sizes is essential to interpreting the sustainability of forest harvests from element mass-balance studies. The soil-exchangeable pool is classically viewed as the bank of "available" base cations in the soil, withdrawn upon by plant uptake and leaching and refilled by litter decomposition, atmospheric deposition and mineral weathering. The operational
Despite advances in the treatment quality of HIV throughout the world, several countries are still facing numerous obstacles in delivering HIV treatment at a sufficiently high quality, putting patients' lives in jeopardy. The aim of this status article is to give an overview of HIV treatment outcomes in the West African country, Guinea-Bissau, and to assess how newer treatment strategies such as l
The immune system has evolved through thousands of years and its architecture has challenged the medical field since the first hieroglyphs and will likely continue do so. With our co-evolution with millions of other species, the complexity to treat infectious diseases has been a race in increasing speed ever since. The establishment of penicillin shortened the length of that battle against a broad
To address the importance of antigen-presenting cells for the survival of intracerebral neural allografts, allogeneic spleen cells were added to the graft tissue before transplantation. Dissociated embryonic, dopamine-rich mesencephalic and adult spleen tissues were prepared from either inbred Lewis or Sprague-Dawley rats. A mixture of neural and spleen cells was sterotaxically transplanted into t
Objective: Genome-wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS comprises one quarter of all ischemic stroke and is a major manifestation of cerebral small vessel disease, the primary cause of vascular cognitive impairment. Studies across neuro
Background: To prevent posterior capsule opacification (PCO), we followed the hypothesis that calcium channel blockers (antagonists) interfere with integrin signaling and block cell adhesion in lens epithelial cells (LEC). In primary human LEC we found that the T channel antagonist mibefradil induces apoptosis which was accompanied with cell shape changes and loss of cell adhesion. Although T-type
Background Late blight (caused by Phytophthora infestans) is a devastating potato disease that has been found to occur earlier in the season over the last decades in Fennoscandia. Up until now the reasons for this change have not been investigated. Possible explanations for this change are climate alterations, changes in potato production or changes in pathogen biology, such as increased fitness o
Objective Emotion regulation group therapy (ERGT) has shown promising results in several efficacy trials. However, it has not been evaluated outside a research setting. In order to increase the availability of empirically supported treatments for individuals with borderline personality disorder and deliberate self-harm, an evaluation of ERGT in routine clinical care was conducted with therapists o
