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Patients admitted to intensive care after cardiac arrest are at risk of circulatory shock and early mortality due to cardiovascular failure. The aim of this study was to evaluate the ability of the veno-arterial pCO2 difference (∆pCO2; central venous CO2 – arterial CO2) and lactate to predict early mortality in postcardiac arrest patients. This was a pre-planned prospective observational sub-study
Nitrogenase is the only enzyme that can convert N2 into NH3. The reaction requires the addition of eight electrons and protons to the enzyme and the mechanism is normally described by nine states, E0–E8, differing in the number of added electrons. Experimentally, it is known that three or four electrons need to be added before the enzyme can bind N2. We have used combined quantum mechanical and mo
Popular Abstract in Swedish Antagandet att människor är förmögna att kontrollera och avsiktligt glömma oönskade minnen har varit kontroversiellt allt sedan Freud (1915/2000) först antog den typen av psykologisk process. Men aktuell experimentell forskning ger ökat belägg för att avsiktligt undertryckande av oönskade minnen faktiskt kan leda till senare glömska (cf. Levy & Anderson, 2002). ResuForgetting can be highly functional when unwanted or irrelevant memory representations interfere with cognitive or motivational goals. Current theory assumes that forgetting can be brought about by the intentional or unintentional inhibition of interfering memory representations. In four studies, the present thesis investigated this claim by employing behavioral testing, and neuroimaging methods b
An ability to interact with plasminogen or plasmin could provide micro-organisms with a mechanism for invasion. Thus, group A, C and G streptococci secrete streptokinase which binds and activates plasminogen. Some streptococci also express surface structures which bind plasminogen without causing its activation. Plasminogen-binding surface proteins were extracted from one group C and one group G s
The aim of this study is to generate a quality-controlled sub-kilometer dataset of the fraction of absorbed photosynthetically active radiation (FAPAR) across Scandinavia from satellite. FAPAR is required for estimating the amount of PAR absorbed (APAR) by vegetation, which in turn allows for estimation of carbon uptake. In this study, FA-PAR was modeled from normalized difference vegetation index
Issue management in market-driven software projects is constantly under time pressure. A limited set of developers must share their time between developing features for the next release and resolving reported issues. Project managers need to find the appropriate balance between a high quality product and fast time to market. We study a telecom company in Sweden developing embedded systems for a co
Second harmonic generation is popular due to its numerous applications in different technologies dealing with multiple fields of science. The rapid technical advancement with the second harmonic generation demands parallel development in the theoretical understanding. With this view in mind, in our three papers, we theoretically investigated second harmonic generation from different systems in an
Objective: To systematically evaluate the ability of the CINA® LVO software to detect large vessel occlusions eligible for mechanical thrombectomy on CTA using conventional neuroradiological assessment as gold standard. Methods: Retrospectively, two hundred consecutive patients referred for a brain CTA and two hundred patients that had been subject for endovascular thrombectomy, with an accessible
Purpose: We assessed long-term outcomes in acutely admitted adult patients with delirium treated in intensive care unit (ICU) with haloperidol versus placebo. Methods: We conducted pre-planned analyses of 1-year outcomes in the Agents Intervening against Delirium in the ICU (AID-ICU) trial, including mortality and health-related quality of life (HRQoL) assessed by Euroqol (EQ) 5-dimension 5-level
Background: Few individuals with alcohol use disorders receive treatment. Primary care has been suggested as an arena for early treatment for these disorders. Aim: To evaluate whether the presence of a specialized addiction nurse can increase alcohol-related physician consultations in a primary care setting. Method: This controlled intervention study included one intervention and one control prima
Pyocyanin, a redox-active secondary metabolite produced by Pseudomonas aeruginosa, serves as a crucial virulence factor. Detection and quantification of pyocyanin can aid early diagnosis of infection. A selective and sensitive molecularly imprinted electrochemical sensor was constructed by using a green polymerization technique to deposit an ultrathin polydopamine film on an electrode modified wit
The input of strontium from aquatic resources in an omnivorous diet has been researched to a lesser degree than that of terrestrial sources, which, in specific sociocultural settings, complicates the study of provenance and mobility. To address this lack of research and to investigate forager mobility in an archipelago environment, where access to terrestrial resources was limited and earlier stud
This study explores the interplay between gender, gaming, and cultural memory through the case of Code: Kite, a Chinese female-oriented historical game that reimagines the Three Kingdoms era from a female perspective. Drawing on semi-structured interviews with eleven female players and analyzed through thematic analysis, the research examines how players perceive gender expression in the game, how
Since ancient times, public squares have played a significant role in the social and political life of towns and cities. They were designed as open spaces for public use, allowing people to meet, communicate, and demonstrate, and as centers for commercial and civic culture that reflected historical transformations. However, nowadays, public squares are often nearly abandoned urban voids, rather th
Cultural institutions such as museums and art galleries are important agents in educating the broader public on matters where current awareness is missing, inadequate or inaccurate. In this study, I focus on one such matter, which is the knowledge regarding ethnic minorities, their history, traditions, and current challenges. My primary focus is on how cultural institutions utilise their exhibitio
