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Some parasites are expected to have beneficial impacts on wild populations in polluted environments because of their bioaccumulation potential of pollutants from their hosts. The fate of organic micropollutants in host-parasite systems and the combined effect of parasitism and pollution were investigated in chub Squalius cephalus, a freshwater fish, infected (n = 73) or uninfected (n = 45) by acan

If places indeed matter, as economic geographers believe, then it must matter most to the people who live their everyday lives in these places and experience the world materially and socially through it. When a crisis hits and uncertainty ensues, it affects people who call these places home the most. So much so, that some of them might be willing to stake a claim on its recovery, and development

BACKGROUND: Basal cell carcinoma (BCC) is the most common skin cancer. Incidence is largely unknown because of incomplete, or lack of, registration in most countries.OBJECTIVES: To assess current incidence rates and recent trends for BCC in the Swedish population.METHODS: Patient- and tumour-related features of all histologically confirmed BCC tumours diagnosed in Sweden from 2004 to 2017 were ext

A new generation of potent hDHODH inhibitors designed by a scaffold-hopping replacement of the quinolinecarboxylate moiety of brequinar, one of the most potent known hDHODH inhibitors, is presented here. Their general structure is characterized by a biphenyl moiety joined through an amide bridge with an acidic hydroxyazole scaffold (hydroxylated thiadiazole, pyrazole and triazole). Molecular model

The aim of this study was to synthesize and characterize a nano-hydroxyapatite (nHAP) and calcium sulfate bone substitute (NC) for cranioplasty. The NC was functionalized with low concentrations of bone morphogenetic protein-2 (BMP-2) and zoledronic acid (ZA) and characterized both in vitro and in vivo. In vitro studies included MTT, ALP assays, and fluorescent staining of Saos-2 (human osteoblast

Globally, an enormous number of polluted areas are in need of remediation to prevent adverse effects on health and environment. In situ remediation and especially the monitoring thereof needs further development to avoid costly and hazardous shipments associated with excavation. The monitoring of in situ remediation actions needs easier and cheaper nondestructive methods for evaluation and verific

Water loss is a crucial factor for vegetation in the semi-arid Sahel region of Africa. Global satellite-driven estimates of plant CO2 uptake (gross primary productivity, GPP) have been found to not accurately account for Sahelian conditions, particularly the impact of canopy water stress. Here, we identify the main biophysical limitations that induce canopy water stress in Sahelian vegetation and

Inputs of salt spray to the blanket bogs, due to their proximity to the coast and the predominant westerly winds from the Atlantic Ocean. To test this hypothesis we carried out an ecohydrological field study at a large blanket bog in the western part of Connemara, Ireland. We described peat profiles in two transects and sampled pore water from peat at different depths. The water samples were analy

For the last decades, molecular imprinting is developing intensively, especially in the case of the application of new imprinting techniques. In this work, for the first time, a Pickering emulsion polymerization was used to synthesize the S-naproxen-imprinted polymer spheres following a noncovalent protocol. To enhance the knowledge about imprinting process using mentioned technique, thorough anal

Aim: The study was undertaken to explore whether shortening of striated muscle during activity is associated with release of bound Ca2+ into the myofibrillar space as has previously been proposed in order to explain the depressant effect of active shortening. Methods: The experiments were carried out on single muscle fibres isolated from the anterior tibialis muscle of Rana temporaria. The fibres

Haemosporidian parasites (genera Plasmodium and Haemoproteus) are common blood parasites of birds transmitted by dipteran insect vectors. We analyzed blood samples from 329 individuals of 43 bird species in eastern Tennessee to better understand the relationship between the local community of birds and their blood parasites, including the distribution of parasites across hosts and the underlying e

Constraints on the composition of the depleted mantle Sm–Nd and Lu–Hf crust formation ages have a long history of scientific debate. When calculating mantle extraction ages, and constructing crustal growth models, a linear evolution of incompatible trace elements in a depleted mantle since > 4 Ga is routinely used. Mantle depletion however varies regionally and over time and subduction of sediment

Infection with the human gastric pathogen Helicobacter pylori can give rise to chronic gastritis, peptic ulcer, and gastric cancer. All H. pylori strains express the surface-localized protein HpaA, a promising candidate for a vaccine against H. pylori infection. To study the physiological importance of HpaA, a mutation of the hpaA gene was introduced into a mouse-adapted H. pylori strain. To justi

Studies of predator-mediated selection on behaviour are critical for our understanding of the evolution and maintenance of behavioural diversity in natural populations. Consistent individual differences in prey behaviour, especially in the propensity to take risks ("boldness"), are widespread in the animal kingdom. Theory predicts that individual behavioural types differ in a cost-benefit trade-of

This paper describes in depth the design and application considerations of a computer based measurement system enabling 1 MS/s simultaneous sampling of 47 hydrophones for cross sectional recordings of echolocation beams of toothed whales (Odontocetes). An earlier prototype version of the system has previously only been presented as a brief proof of principle that did not offer a complete descripti

Context Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality. Objectives Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone. Design Bi-directional Mendelian randomization (MR) analysis on prospective cohorts. Setting Five cohorts from Denmark, Germany and Sweden (Inte

OBJECTIVE-: The purpose of this study was to characterize a phosphorylation motif at serine 225 as a molecular switch that regulates the pressure-dependent activation of sphingosine kinase 1 (Sk1) in resistance artery smooth muscle cells. METHODS AND RESULTS-: In isolated hamster gracilis muscle resistance arteries, pressure-dependent activation/translocation of Sk1 by ERK1/2 was critically depend