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People form part of the biosphere - the biosphere being the whole intertwined network of life on Earth. While there is convergence on the need for societal change for just sustainability and a healthy biosphere, the pathways to achieve these transformations remain relatively unclear. Through legal interpretation, conceptual and thematic analysis of academic and grey literature, we seek to answer t
BACKGROUND: Owing to the wide spread perception of a possible benefit from paclitaxel in the second-line situation the Nordic Gynecologic Oncology Group (NGOG) conducted two prospective phase II studies of paclitaxel single agent treatment (175 mg/m2, three-hour i.v. infusion with standard pre-medication every third week) in patients with relapsing or progressing epithelial ovarian cancer followin
The incidence of stroke and dementia are diverging across the world, rising for those in low- and middle-income countries and falling in those in high-income countries. This suggests that whatever factors cause these trends are potentially modifiable. At the population level, neurological disorders as a group account for the largest proportion of disability-adjusted life years globally (10%). Amon
UNLABELLED: Persistent CB1 cannabinoid receptor activity limits neurotransmitter release at various synapses throughout the brain. However, it is not fully understood how constitutively active CB1 receptors, tonic endocannabinoid signaling, and its regulation by multiple serine hydrolases contribute to the synapse-specific calibration of neurotransmitter release probability. To address this questi
A major challenge in neuroscience is to resolve the connection between gene functionality, neuronal circuits, and behavior. Most, if not all, neuronal circuits of the adult brain contain a glutamatergic component, the nature of which has been difficult to assess because of the vast cellular abundance of glutamate. In this study, we wanted to determine the role of a restricted subpopulation of glut
The existing information supports the use of this material as described in this safety assessment. Hexyl hexanoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog hexyl isobutyrate (CAS # 2349-07-7) show that hexyl hexanoate is not
Projekt Turnstone är ett samverkansprojekt delvis finansierat av Europeiska kommissionen. Projektet är ett initiativ av Stockholmspolisens gränsbevakningsenhet. Samverkanspartners i projektet är Svenska Kustbevakningen, Region Nord öst; Helsingforspolisen; Gränsbevakningsväsendet, Finland; Polis och Gränsbevakningen i Estland; Statliga Gränsbevakningen, Lettiska republiken; och den Statliga GränssProject Turnstone is a collaborative project funded in part by the European Commission. The project is an initiative by the Stockholm Police. Collaborating partners in the project are the Swedish Coast Guard, Region Northeast; the Helsinki Police; the Gulf of Finland Coast Guard District; the Police and Border Guard Board in Estonia; the State Border Guard of the Republic of Latvia; and the State
Isospin symmetry, combined with shell-model description, has long been successful in reproducing nuclear structure and predicting mirror energy differences. However, these descriptions have been primarily limited to mirror nuclei with well-bound ground states. As one approaches the proton drip line, coupling to the continuum becomes important. Despite this, little is known about medium-mass nuclei
Den svenska produktionen av Science fiction-film är för många okänd. Uppsatsen undersöker vilka svenska filmer som kan klassas som science fiction och hur den svenska konstfilmsinstitutionen inverkat på produktionen. Med utgångspunkt i svenska science fiction-entusiasters sammanställningar, analyseras innehållet kvantitaivt i de långfilmer som gjorts och graderas i en tregradig skala efter hur staThe production of Swedish science fiction is unknown for most people. The thesis studies which Swedish movies that can be classified as science fiction and how the Swedish art cinema institution has affected the production. The movies are analyzed and graded by how strong the science fiction influences are. The result eventuates in 29 Swedish science fiction movies, that strong influences are unco
Stem cell lines that faithfully maintain the regional identity and developmental potency of progenitors in the human brain would create new opportunities in developmental neurobiology and provide a resource for generating specialized human neurons. However, to date, neural progenitor cultures derived from the human brain have either been short-lived or exhibit restricted, predominantly glial, diff
BACKGROUND Targeted temperature management is recommended for patients after cardiac arrest, but the supporting evidence is of low certainty. METHODS In an open-label trial with blinded assessment of outcomes, we randomly assigned 1900 adults with coma who had had an out-of-hospital cardiac arrest of presumed cardiac or unknown cause to undergo targeted hypothermia at 33°C, followed by controlled
Background: Cognitive impairment is common following out-of-hospital cardiac arrest (OHCA), but the nature of the impairment is poorly understood. Our objective was to describe cognitive impairment in OHCA survivors, with the hypothesis that OHCA survivors would perform significantly worse on neuropsychological tests of cognition than controls with acute myocardial infarction (MI). Another aim was
Red blood cell (RBC) and iron status biomarkers are commonly used in clinical diagnostics. However, interpretations of infant test results are inherently challenging. Modern well-defined comparative data based on presumably healthy term-born infants have mainly been lacking and interpretations could be further complicated by interference from frequent infections. Moreover, the trends that follow w
Background: Targeted temperature management (TTM) is recommended following cardiac arrest; however, time to target temperature varies in clinical practice. We hypothesised the effects of a target temperature of 33 °C when compared to normothermia would differ based on average time to hypothermia and those patients achieving hypothermia fastest would have more favorable outcomes. Methods: In this p
Most scholars attribute the development and ubiquity of global value chains to economic forces, treating law as an exogenous factor, if at all. By contrast, we assert the centrality of legal regimes and private ordering mechanisms to the creation, structure, geography, distributive effects and governance of Global Value Chains (GVCs), and thereby seek to establish the study of law and GVCs as rich
BACKGROUND: Circulating adiponectin and leptin have been associated with risk of pancreatic cancer. However, the relationship between long-term exposure to these adipokines in the prediagnostic period with patient survival has not been investigated.METHODS: Adipokine levels were measured in prospectively collected samples from 472 patients with pancreatic cancer. Because of sex-specific difference
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https://www.lth.se/forskning/profilomraaden/ai-och-digitalisering/ - 2026-07-06
