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Background: Large bone defects are challenging to manage clinically and usually require treatment with bone graft or bone graft substitute. This study evaluated the effect of romosozumab, a sclerostin antibody, in combination with demineralized bone matrix (DBM) on bone regeneration in a critical-size ulnar defect model in nonhuman primates. Methods: In cynomolgus monkeys (N = 22, male, 10–12 year
Many first trimester sporadic miscarriages are unexplained and the role of environmental exposures is unknown. The present aim was to study if levels of Perfluoroalkyl substances (PFASs) in early pregnancy are associated with unexplained, sporadic first trimester miscarriage. The study was performed within the Swedish SELMA pregnancy cohort. Seventy-eight women with non-recurrent first trimester m
Introduction: Postnatal pesticide exposure and its association with child and adolescent behavioural outcomes remain underexplored in rural agricultural settings, particularly in Africa. This study examined behavioural outcomes in relation to urinary pesticide biomarkers and contextual exposure proxies in participants from the Child health Agricultural Pesticide (CapSA) cohort, South Africa. Metho
Asthma is a common, multifaceted respiratory disease with a major impact on quality of life. Despite increased insights into mechanisms underlying various asthma phenotypes and endotypes and the availability of targeted biologic treatment options, the disease remains uncontrolled in a substantial proportion of patients with risk of exacerbations, requiring systemic corticosteroids, and with progre
Objective: Both attention-deficit/hyperactivity disorder (ADHD) and neighborhood deprivation have been previously associated with an increased risk of type 2 diabetes (T2D). However, the potential association between neighborhood deprivation and T2D in ADHD patients remains underexplored. Our aim was to study the potential effect of neighborhood deprivation on incident T2D in patients with ADHD. M
This article suggests a model for lexical verb semantics that unifies Halliday’s model for transitivity with Langacker’s concept of base and profile and also with a model for situation type (cf. Smith 1997). It is claimed that verbs adhere to one of four macro domains: the material, the social, the mental or the relational domain. Within these domains there are numerous types of verbs, such as mot
Purpose: We aimed at analysing the risk of congestive heart failure (CHF) among first- and second-generation immigrants in younger age groups. Methods: All individuals aged 18–54 years, n = 3 973 454 in the first-generation study and n = 3 817 560 in the second-generation study, were included. CHF was defined as at least one registered diagnosis in the National Patient Register between 1 January 1
Background: Summary statistics often hide individual patients' suffering, thereby impeding quality improvement efforts. Objectives: We aimed to show the experience of a population with health care toward the end of life while preserving the experience of the individual. Design: We developed a data display method called per-patient illness trajectory analysis. We tested it using a demonstration coh
Aims Previous studies on disparities in healthcare and outcomes have shown conflicting results. The aim of this study was to assess differences in baseline characteristics, management, and outcomes in myocardial infarction (MI) patients, by country of birth. Met hods a nd results In total, 194 259 MI patients (64% male, 15% foreign-born) from the nationwide SWEDEHEART (The Swedish Web-system for E
BackgroundIn a previous phase II trial, intraperitoneal local anaesthetics shortened the time interval between surgery and adjuvant chemotherapy, an endpoint associated with improved survival in advanced ovarian cancer. Our objective was to test this in a phase III trial.MethodsA double-blind, phase III parallel superiority trial was conducted at two university hospitals in Sweden, within a public
The European Academy of Andrology (EAA) celebrates its 30th anniversary in 2022. An important part of the Academy's history is its scientific publishing activity, which started with the International Journal of Andrology (Int J Androl), and continued with Andrology, the journal created and overseen jointly by the EAA and the American Society of Andrology (ASA). The year 2022 marks the first decade
The carnivorous pitcher plant Sarracenia purpurea is native to North America, but has been introduced into Europe, where it is now widespread. Understanding of how this species functions in its non-native range is limited. We measured pitcher morphology and prey capture by S. purpurea in its non-native range in Britain and Ireland. Pitchers were removed from different plants at each of six bogs co
Background: Heart failure (HF) has been associated with psychosocial distress, but other long-term mental health sequelae are unclear. Objectives: In this study, the authors sought to determine risks of major depression and suicide, susceptible time periods, and sex-specific differences after HF diagnosis in a large population-based cohort. Methods: A national cohort study was conducted of all 154
Adverse childhood experiences (ACE) and high levels of disinhibition have been associated with a variety of negative outcomes such as aggressive antisocial behavior (AAB). However, forensic psychiatric populations remain an understudied group in this field of research. This study aimed to fill that gap by investigating associations between ACE, AAB, and disinhibition in a forensic psychiatric samp
Aiming to compare capability across persons with impairments using and not using assistive products and persons without impairments in Bangladesh for 16 different functionings, we contrast two sets of self-reported cross-sectional data from eight districts of Bangladesh: (i) data from persons with hearing impairment not using hearing aids, persons with hearing impairment using hearing aids and per
Knowledge in statistics is essential to draw solid conclusions from data. This chapter covers the basic concepts needed to navigate in the world of biostatistics, with the aim that the reader should know what to search for when encountering new situations. First, the chapter introduces basic concepts such as scales of measurement, relation between sample and population, and features of stochastic
Diagnostic nuclear medicine, more recently also named functional molecular imaging, deals with medical procedures performed to help diagnose a variety of diseases. The procedures are based on the use of tracer amounts of radioactive material, where a radionuclide is attached to a ligand with specific affinity to a physiological, metabolic, or receptor-specific process. To balance the benefit of a
Introduction: Few, if any, prior studies have considered whether undetermined intent (UDI) deaths and suicide deaths differ with respect to genetic liability for suicidal behavior or psychopathology. Methods: The authors used Swedish national registry data to identify suicide deaths (N = 31,835) and UDI deaths (N = 10,623); sociodemographic covariates; and registrations for psychopathology. Family
