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Understanding and therapeutic targeting of lysosome-dependent cell death 1. Deciphering the molecular machinery of lysosome-dependent cell death and its interactions with other cell death and survival processes 2. Understanding the role of lysosomes in diseases with altered cell death 3. Therapeutic modulation of lysosome-dependent cell death 4. Development of novel tools and methods for study

Our ultimate research vision is to discover, develop and implement novel neuroprotective and neurorestorative therapies for neurological disorders such as Parkinson’s disease, Huntingtons disease and stroke. My group works with translational research that is tightly linked to clinical research questions. Our experimental focus is to understand neurovascular disease mechanisms. We examine the dysfu

The target group of our research is adults with limitations in participation and everyday life due to illness, injury or age. Our research is based on theories and models derived mainly within occupational therapy and occupational science, gerontology, rehabilitation, health economics, evaluation and implementation research. The research group is linked to the Centre for Ageing and Supportive

Our research uses advanced technology to generate neurons from novel cell sources with the aim to extensively define the subtype and function of the generated neurons and their potential for therapeutic use in the future. For this we are using reprogramming technology in animal models or human stem cell culture system, together with electrophysiology, RNA sequencing, tracing technologies and cell

Centre for Innovation Research – CIRCLE – is an interdisciplinary centre which connects innovation researchers from different faculties at Lund University as well as other Swedish and international universities. The meaning of the term innovation has transformed and is now tightly linked to sustainable development goals including climate change, social sustainability and food security. CIRCLE’s a

Uppsatsen har undersökt huruvida spelföretaget Star Stable Entertainment AB marknadsföring av virtuella valutor och produkter till barn bryter mot EU:s konsumentskyddslagstiftning i ljuset av Sveriges Konsumenters anmälan mot företaget. Uppsatsen har även diskuterat om direktivet om otillbörliga affärs-metoder är anpassat för den digitala miljön med hänsyn till kommissionens aktuella fitness checkThe essay analyses whether the gaming company Star Stable Entertainment AB´s marketing of virtual currencies and other virtual products against chil-dren violates EU consumer law, considering the Swedish Consumers Associ-ation’s complaint against the company. The paper also discusses whether the Unfair Commercial Practice Directive (UCPD) is fit for the digital environ-ment, given the European Com

Bacterial infections spanning from local wound infections, affecting patients with non-healing leg ulcers, postoperative wounds or burns, to severe infections and sepsis, are significant medical problems. Today's anti-infective treatments do not address the excessive activation of inflammatory pathways during infection and sepsis, and resistance problems are increasing. Hence, there is a huge unmBacterial infections spanning from local wound infections, affecting patients with non-healing leg ulcers, postoperative wounds or burns, to severe infections and sepsis, are significant medical problems. Today's anti-infective treatments do not address the excessive activation of inflammatory pathways during infection and sepsis, and resistance problems are increasing. Hence, there is a huge unm

Epilepsy is a devastating neurological disorder characterized by synchronous neuronal activity, which manifests as epileptic seizures. It usually develops after an initial insult, such as head trauma or stroke, which triggers the epileptogenic process. During epileptogenesis, the affected brain regions undergo multiple changes in connectivity and gene expression, and among the most affected genes Epilepsy is a devastating neurological disorder characterized by synchronous neuronal activity, which manifests as epileptic seizures. It usually develops after an initial insult, such as head trauma or stroke, which triggers the epileptogenic process. During epileptogenesis, the affected brain regions undergo multiple changes in connectivity and gene expression, and among the most affected genes

Följderna av narkotikamissbruk kostar samhället stora summor pengar varje år. Att beräkna den exakta storleken på dessa summor är omöjligt, eftersom stora delar av den narkotikarelaterade verksamheten är olaglig. De kostnadsberäkningar man kan göra blir ungefärliga uppskattningar. Ändå är det viktigt att försöka, eftersom den kunskap man har om kostnaderna för narkotikamissbrukets konsekvenser utg

Injectable Bioresorbable Organic Bioelectronics Neuropharmacology—our ambition is to supplement classical biochemical signaling with the modulation of bioelectricity using both ionic and electronic processes. We focus on organic electronics that self-assemble directly inside or near the nervous system to form electronic circuits that mimic its structure and organization, enabling seamless integratInjectable Bioresorbable Organic Bioelectronics Neuropharmacology—our ambition is to supplement classical biochemical signaling with the modulation of bioelectricity using both ionic and electronic processes. We focus on organic electronics that self-assemble directly inside or near the nervous system to form electronic circuits that mimic its structure and organization, enabling seamless integrat

In diffusion MRI (dMRI), images are sensitised to water diffusion by the application of magnetic field gradients. Cell membranes hinder the diffusional motion and thereby contribute to the contrast in dMRI. Thus, the diffusion of water molecules is used a probe of tissue microstructure. Data from dMRI is often analysed using diffusion tensor imaging (DTI), which yields image biomarkers that reflecIn diffusion MRI (dMRI), images are sensitised to water diffusion by the application of magnetic field gradients. Cell membranes hinder the diffusional motion and thereby contribute to the contrast in dMRI. Thus, the diffusion of water molecules is used a probe of tissue microstructure. Data from dMRI is often analysed using diffusion tensor imaging (DTI), which yields image biomarkers that reflec

Our research group on paediatric haematology is focused on bleeding- and coagulation disorders in children, in particular on haemophilia and venous thrombosis. Haemophilia A and B are hereditary, X chromosomal recessive bleeding disorders caused by deficiency or absence of coagulation factors VIII (FVIII) or IX (FIX) in the blood. The general aim of this part of the research program is to improve Our research group on paediatric haematology is focused on bleeding- and coagulation disorders in children, in particular on haemophilia and venous thrombosis. Haemophilia A and B are hereditary, X chromosomal recessive bleeding disorders caused by deficiency or absence of coagulation factors VIII (FVIII) or IX (FIX) in the blood. The general aim of this part of the research program is to improve