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Japan’s influence in Southeast Asia has been enormous throughout history, whether in its military occupation, culture, or economic ties, and there is no doubt that Southeast Asia has developed under its influence. Have Southeast Asian states then developed and improved their human rights situation because of Japan? Or has Japan aggravated the situation being “blue washed”, by performing its busine
I min avhandling undersöker jag varierande placering av objekt till verb i svenskans historia. Primärt undersöks placering av nominala objekt visavi negerande adverbial, och sekundärt undersöks placering av nominala objekt visavi andra argument (subjekt och objekt) i huvudsatser. Materialet som ligger till grund för avhandlingen är texter från äldre och yngre fornsvenska (1225-1526), och huvudsaklThis thesis focuses on the distribution of objects in the history of Swedish. The primary focus of the thesis is the distribution of objects relative to negation, and the secondary focus is varying order of nominal arguments in Old Swedish (1225–1526).In Modern Swedish, objects may precede the negation, often referred to as Object Shift, OS, or precede a subject, often referred to as Long Object S
The timing and connections between global cooling, marine redox conditions, and biotic turnover are underconstrained for the Late Ordovician. The second most severe mass extinction occurred at the end of the Ordovician period, resulting in ~85% loss of marine species between two extinction pulses. As the only “Big 5” extinction that occurred during icehouse conditions, this interval is an importan
Aquatic organisms are constantly at risk of being exposed to potentially harmful chemical compounds of natural or anthropogenic origin. Biological life can for instance respond to chemical stressors by changes in gene expression, and thus, certain gene transcripts can potentially function as biomarkers, i.e. early warnings, of toxicity and chemical stress. A major challenge for biomarker applicati
The covid-19 pandemic was characterized by a series of variants of concern, different strains of SARS-CoV-2 which had a serious impact on transmission. One of these, denoted Omicron, dominated in early 2022 and caused covid-19 cases to soar. The increased transmission during the Omicron wave triggered hospitals to further strengthen airborne precautions. The reason for this surge in cases during O
In this special session we wish to critique and reimagine the anthropocentric present. In contemporary consumerist society (Schmitt et al., 2022), the global “free market” is presented as the solution to the environmental and climate urgency through pillars like unlimited growth, responsibilized consumers, and not least, the domination of Nature (e.g. Hornborg 2019). There are alternatives, but thIn this special session we wish to critique and reimagine the anthropocentric present. In contemporary consumerist society (Schmitt et al., 2022), the global “free market” is presented as the solution to the environmental and climate urgency through pillars like unlimited growth, responsibilized consumers, and not least, the domination of Nature (e.g. Hornborg 2019). There are alternatives, but th
Immunoglobulin G (IgG) is the main isotype of antibody in human blood. IgG consists of four subclasses (IgG1 to IgG4), encoded by separate constant region genes within the Ig heavy chain locus (IGH). Here, we report a genome-wide association study on blood IgG subclass levels. Across 4334 adults and 4571 individuals under 18 years, we discover ten new and identify four known variants at five loci
Mosaic chromosomal alterations (mCAs) in hematopoietic cells increase mortality and risk of hematological cancers and infections. We investigated the landscape of mCAs and their clinical consequences in 976 patients with multiple myeloma undergoing high-dose chemotherapy and autologous stem cell support (ASCT) with median 6.4 years of follow-up. mCAs were detected in the stem cell harvest product
The rapid proliferation of data across diverse fields has accentuated the importance of accurate imputation for missing values. This task is crucial for ensuring data integrity and deriving meaningful insights. In response to this challenge, we present Xputer, a novel imputation tool that adeptly integrates Non-negative Matrix Factorization (NMF) with the predictive strengths of XGBoost. One of Xp
The function of astrocytes intertwines with the extracellular matrix, whose neuron and glial cell-derived components shape neuronal plasticity. Astrocyte abnormalities have been reported in the brain of the mouse model for fragile X syndrome (FXS), the most common cause of inherited intellectual disability, and a monogenic cause of autism spectrum disorder. We compared human FXS and control astroc
The immersion freezing ability of soot particles has in previous studies been reported in the range of low/insignificant to very high. The aims of this study were to: (i) perform detailed physico-chemical characterisation of freshly produced soot particles with very different properties, (ii) investigate the immersion freezing ability of the same particles, and (iii) investigate the potential link
Thousands of non-coding variants have been associated with increased risk of human diseases, yet the causal variants and their mechanisms-of-action remain obscure. In an integrative study combining massively parallel reporter assays (MPRA), expression analyses (eQTL, meQTL, PCHiC) and chromatin accessibility analyses in primary cells (caQTL), we investigate 1,039 variants associated with multiple
Background. Airborne SARS-CoV-2 plays a prominent role in COVID-19 transmission. Numerous studies have sampled air from patient rooms, but airborne spread to other hospital areas such as corridors is less investigated. Methods. Size-fractionated aerosol particles were collected weekly, with 12 hours of sampling time daily, in corridors at two infectious disease wards in southern Sweden between Mar
BackgroundCurrent guidelines from Scandinavian Neuro Committee mandate a 24-hour observation for head trauma patients on anticoagulants, even with normal initial head CT scans, as a means not to miss delayed intracranial hemorrhages. This study aimed to assess the prevalence, and time to diagnosis, of clinically relevant delayed intracranial hemorrhage in head trauma patients treated with oral ant
