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Despite the availability of new drugs on the clinics in recent years, drug-resistant epilepsy remains an unresolved challenge for healthcare, and one-third of epilepsy patients remain refractory to anti-seizure medications. Gene therapy in experimental models has emerged as effective treatment targeting specific neuronal populations in the epileptogenic focus. When combined with an external chemic
To be a caregiver while also being next of kin is emotionally charged. This article discusses narratives of care that goes beyond what Amelia DeFalco calls “caregiving at the limit”, i.e. care necessary for basic survival. In these narratives of what we call desperate care, not only is life at stake, but the care is anxious and urgent, partly done against the will of the care recipient, and the ca
Transmissibility has increased during the evolution of SARS-CoV-2, possibly by improved airborne transmission. An increased transmission was noted also in many hospitals. We analyzed SARS-CoV-2 in room air of hospitalized Omicron infected patients and compared results with previous findings with pre-Delta variants to study if SARS-CoV-2 was more prevalent in patient rooms after the introduction of
In vivo proton magnetic resonance spectroscopy (1H-MRS) data often exhibit baselines or low-amplitude signal variations resulting from residual water, imperfectly suppressed lipids, low-amplitude metabolites not considered for fitting, and other features not represented in a basis set. While multitudinous approaches exist to model these baselines in 1H-MR spectral analysis, many continue to lack s
We study under which conditions a first-order phase transition in a composite dark sector can yield an observable stochastic gravitational-wave signal. To this end, we employ the Linear-Sigma model featuring Nf = 3, 4, 5 flavours and perform a Cornwall-Jackiw-Tomboulis computation also accounting for the effects of the Polyakov loop. The model allows us to investigate the chiral phase transition i
Ov Cristian Norocels artikel diskuterar den svenska högerradikala populismenutifrån ett feministiskt perspektiv. Han kartlägger Sverigedemokraternas omtolkningar av den nationella metaforen om ”det svenska folkhemmet” och analyserar konstruktionen av maskuliniteter inom svensk högerradikal populism. Norocel för fram en specifik tolkning av den begreppsliga metaforteorin, en tolkning som innefattar
The X-linked DDX3X gene encodes an ATP-dependent DEAD-box RNA helicase frequently altered in various human cancers, including melanomas. Despite its important roles in translation and splicing, how DDX3X dysfunction specifically rewires gene expression in melanoma remains completely unknown. Here, we uncover a DDX3X-driven post-transcriptional program that dictates melanoma phenotype and poor dise
For patients living with chronic conditions, the daily life will change due to symptoms, drug treatment, and psychosocial factors caused by the disease. Our studies show that Swedish patients with PAH or CTEPH are satisfied with the information they have received, but still have a wish for more. Therefore, it is important to repeat the information on a regular basis and to make sure that patients
Purpose: The purpose of this paper is to enhance the heat transfer and thermal performance in the trailing edge region of the vane with vortex generators (VGs). Design/methodology/approach: This numerical study presents the enhancement of thermal performance in the trailing part of a gas turbine blade. In the trailing part, generally, pin fins are used either in staggered or in-line arrangements t
We are facing a climate and ecological emergency. On all levels in society and the economy, there is a need to work towards climate neutrality and sustainable development. A key way to address global and local complex challenges is through cities. But how can we design, create and achieve climate neutral and sustainable cities? This compendium focuses on how to support individuals and organisation
Objectives: The authors aimed to evaluate whether blood cadmium (B-Cd), lead (B-Pb) and mercury (B-Hg) in children differ regionally in 9 countries, and to identify factors correlating with exposure. Material and Methods: The authors performed a cross-sectional study of children aged 7–14 years, living in 2007–2008 in urban, rural, or potentially polluted (“hot spot”) areas (ca. 50 children from e
Reception – hospitality and hostilityMarcus Knutagård and Arne KristiansenSchool of Social Work, Lund UniversityThe aim of this paper is to analyse the practice of reception of newly arrived migrants. The paper is part of an ongoing project Scanian homes: Reception, settlement or rejection – homelessness policies and strategies for refugee settlement. The aim of the project is to investigate the p
This paper presents views of six Dutch development NGOs on possibilities and threats of social media for their work. A systematic analysis of the literature and the systematic analysis of the interviews yield an interesting theoretical framework in which social media characteristics are cross-referenced with NGO organisational characteristics. The resulting preliminary framework of emerging themes
Prior to the operation of the first Belarussian nuclear power plant (BelNPP), the baseline of the radiation environment was determined within a radius of about 30 km from BelNPP. This independent assessment was carried out during two expeditions in 2019. In 2022, a similar survey was carried out (during the initialoperation of BelNPP) on the Lithuanian side of the boarder. Here we present the over
