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Changes in drug use in the general population during the COVID-19 pandemic and their long-term consequences are not well understood. We employed natural language processing and machine learning to analyse a large dataset of self-reported rates of and reasons for drug use during the pandemic, along with their associations with anxiety, depression and substance use problems post-pandemic. Our findin
Labile organic carbon is a major nutrient, controlling microbial activity in aquatic ecosystems and contributing to the global cycling of carbon. During the production and distribution of drinking water, labile carbon fractions often escape treatment, which threatens water quality and biostability. This study proposes and compares two rapid methods for monitoring the production and removal of labi
Background: Concerns about the cardiovascular safety of medications used for the treatment of attention-deficit hyperactivity disorder (ADHD) remain. We aimed to compare the effects of pharmacological treatments for ADHD on haemodynamic values and electrocardiogram (ECG) parameters in children, adolescents, and adults. Methods: For this systematic review and network meta-analysis, we searched 12 e
During a series of writing workshops at a shelter for young homeless people in Copenhagen, I examined to what extent the literary practice of student-driven imitation with its emphasis on self-governance and a dialogical approach can engage marginalized learners in reading and writing. I found that studentdriven imitation had the potential to engage different kinds of writers and that they adopted
This article is a collective response to the 2020 iteration of The Manifesto for Teaching Online. Originally published in 2011 as 20 simple but provocative statements, the aim was, and continues to be, to critically challenge the normalization of education as techno-corporate enterprise and the failure to properly account for digital methods in teaching in Higher Education. The 2020 Manifesto cont
Given the complex nature of agri-food value chains and related sustainability challenges, the question arises who has the agency and responsibility to address these challenges and facilitate systemic change. We address this question through a mixed method approach and examine experiences with agriculture among different actors along the agricultural value chains in Germany. Based on this, we explo
The aim was to identify treatment-related risk factors for diabetes in 5-year survivors of childhood cancer (CCS). This case-cohort study within Adult Life after Childhood Cancer in Scandinavia (ALiCCS) included 140 CCS with diabetes and a subcohort of 390 randomly selected CCS. Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated to assess the association between treatm
Aims: Stratifying renal damage in type 2 diabetes is challenging due to overlapping features between diabetic nephropathy (DN) and non-diabetic renal disease (NDRD). While miR-27b-3p modulates kidney fibrosis in DN through the lysine63 ubiquitination pathway, its upstream regulation and diagnostic relevance remain unclear. Methods: In a biopsy-verified cohort of 231 chronic kidney disease (CKD) pa
The vast majority of patients with pancreatic cancer present with unresectable disease and precision medicine is lagging behind. Circulating tumor DNA (ctDNA) has emerged as a promising tool, both as a proxy for tumor burden and for capturing tumor heterogeneity, but optimal gene panels and prognostic cutoffs remain to be determined. Herein, we applied ultra-deep ctDNA sequencing using a customize
Introduction Neoadjuvant therapy is the standard of care for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC). Studies on first-generation antibody-drug conjugates, such as trastuzumab emtansine (T-DM1), showed equal or slightly lower efficacy than chemotherapy combined with dual HER2 blockade. Trastuzumab deruxtecan (T-DXd) is a next-generation conjugat
Firms require multi-stakeholder ecosystems to successfully create and implement circular business models for electric vehicle (EV) battery second life. However, there is a notable absence of guiding instruments to assist EV battery ecosystem actors in formulating and managing strategies for battery second-life operations. This study's aim is to analyze how circular ecosystems are formed and manage
Background: Expanding access to self-management via Digital Health Technologies may supplement traditional care, mitigating pressures on primary care through self-management. Primary Care Physicians (PCP) can play a critical role in the integration of digital health technologies into patient care, but it is unclear what factors influence PCPs’ recommendation of such technologies. Aims: To identify
BACKGROUND AND OBJECTIVE: Bacillus Calmette-Guérin (BCG) reduces disease recurrence and progression in intermediate- and high-risk non-muscle-invasive bladder cancer (NMIBC). BCG-associated adverse events during instillations are common, leading to treatment cessation. Prophylactic use of quinolones in conjunction with BCG instillations is one approach for reducing BCG-associated adverse events. O
Chapter 3 examines the techniques and elements of paramilitarism through the intersections of both domestic and foreign policy. By focusing on extralegal activities as a derivative of state violence, the interactions between domestic and foreign policy and the continuities of unconventional warfare are analyzed. Specifically, it explores how Turkey has acquired and transformed modern forms of unco
Emerging from the citizen movements of the early 2010s, New Municipalism merges the administrative capacity of municipal government with the organizational capacities of activists and social movements to build more equal, just and ecological local economies. In these contexts, Digital Municipal Currencies (DMCs) emerge as potent instruments of counter-hegemonic struggle, enabling cities to impleme
BACKGROUND: This systematic review and meta-analysis aimed to assess the diagnostic test accuracy of blood-based biomarkers (BBMs) for detecting Alzheimer's disease (AD) pathology in cognitively impaired individuals in specialized care settings. The overarching goal is to inform the development of a clinical practice guideline, led by the Alzheimer's Association, for use in clinical practice. METH
Stable carbon isotope curves derived from Lower Triassic carbonate rocks from three Iranian sections are established to investigate changes in the carbon cycle during the Early Triassic in this area. The sections are located in the south-center (Abadeh), north (Amol), and northwest (Zal) of Iran. All three curves show a similar pattern starting out with high δ13C values in the uppermost Permian de
This Letter presents a search for highly ionizing magnetic monopoles in (Formula presented) of ultraperipheral (Formula presented) collision data at (Formula presented) collected by the ATLAS detector at the LHC. A new methodology that exploits the properties of clusters of hits reconstructed in the innermost silicon detector layers is introduced to study highly ionizing particles in heavy-ion dat
