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This article summarizes the current understanding of the heterogeneity of type 1 diabetes from a June 2024 international Expert Forum organized by the editors of Diabetes, Diabetes Care, and Diabetologia. The Forum reviewed key factors contributing to the development and progression of type 1 diabetes and outlined specific, high-priority research questions. Knowledge gaps were identified, and, not
This article summarizes the current understanding of the heterogeneity of type 1 diabetes from a June 2024 international Expert Forum organized by the editors of Diabetes, Diabetes Care, and Diabetologia. The Forum reviewed key factors contributing to the development and progression of type 1 diabetes and outlined specific, high-priority research questions. Knowledge gaps were identified, and, not
Methanol is a promising renewable fuel that can be used to reduce the carbon intensity of internal combustion engines. In any combustion strategy with methanol, both unburned methanol and formaldehyde emissions are criteria pollutants that are potential drawbacks, so their accurate measurement is critical. The flame ionization detectors (FIDs) typically used in engine research to measure unburned
Patterns of correlations among judgments of targets on different attributes are the basis for common psychometric procedures such as factor analysis and network modeling. The outcomes of such analyses may shape the images (i.e., theories) that we as scientists have of the phenomena that we study. However, key conceptual issues tend to be overlooked in these analyses, which is especially problemati
This chapter is an effort to explore the challenges related to establishing civil liability for independent activities for Maritime Autonomous Surface Ships (MASS) and discusses how these challenges can be addressed in a manner that maintains the balance of interests implied by existing legal mechanisms. The chapter concludes that existing legal mechanisms are insufficient. They fail to recognise
Background: Studies on national policies for biologics are warranted. Objectives: To map and compare national healthcare set-ups for prescription, start, switch, tapering, and discontinuation of biologic/targeted synthetic disease-modifying antirheumatic drugs (DMARDs) in patients with psoriatic arthritis and axial spondyloarthritis across Europe, and assess the healthcare set-ups in relation to c
Background: Postmastectomy radiotherapy (PMRT) impairs the outcome of immediate breast reconstruction in patients with breast cancer, and the sentinel lymph node (SLN) status is crucial in evaluating the need for PMRT. The aim of this study was to develop and validate models to stratify the risk of clinically significant SLN macrometastases (macro-SLNMs) before surgery. Methods: Women diagnosed wi
Most agricultural and food policies often overlook diversity of farming households, resulting in generalized and ineffective interventions. Recognizing changing and diverse characteristics of farm types is therefore critical. Using data from 502 households in West Pokot County, Kenya, we employ principal component and cluster analyses to create farm typologies to guide targeted policy intervention
This study examines the influence of environmental concerns on water conservation behaviors among Gen Z tourists in Iranian desert regions by extending the Norm Activation Theory (NAT). Adopting a quantitative approach, data were collected through a structured questionnaire from 330 Gen Z tourists (born between 1997 and 2012) who visited four Iranian desert villages (Qale Bala, Mesr, Abyaneh, and
The aim of this study is to analyse how a taxonomy-based course design can support students’ qualitative learning processes in online university courses. The paper presents a case study based on two online courses in comparative literature in Swedish and English. A document analysis has been applied to analyse the empirical material, which includes the syllabuses, study guides, and examination ass
The Gaussian phase distribution approximation enables analysis of restricted diffusion encoded by general gradient waveforms but fails to account for the diffraction-like features that may occur for simple pore geometries. We investigate the range of validity of the approximation by random walk simulations of restricted diffusion in a cylinder using isotropic diffusion encoding sequences as well a
Studies investigating how the number of children in a family affects the parents or the children face problems because the variable of interestis endogenous in the model. The currently accepted solution to this problem is to use instrumental variables (IVs), for example, based on twin births. In this paper, I review and add to the critique of IVs based on twin births and show that that there are
Being the premier forum for automotive user interface research and other vehicular technologies, AutomotiveUI concerns professionals, academics, researchers, and industry representatives from all around the world interested in innovation, research, and application of automotive user interface topics, embodying diversity at its core. This diversity is however not always reflected in the conference'
Introduction: Carbon monoxide (CO) is a leading cause of environmental poisoning in the United States with substantial mortality and morbidity. The mechanism of CO poisoning is complex and includes hypoxia, inflammation, and mitochondrial dysfunction. Currently both biomarkers and therapies for CO poisoning are limited and require new approaches. Methods: Rats (~ 300 g) were divided into four grou
BACKGROUND: The risk of infection-related death is high in patients undergoing dialysis. This study aimed to identify the modifiable risk factors for PD-related infections in patients undergoing peritoneal dialysis.METHODS: This was a population-based retrospective cohort study conducted in Skåne, South Sweden, which included all patients receiving peritoneal dialysis (PD) between 2011 and 2020. T
Background: Rubber accelerators found in rubber gloves may cause contact allergy and thus allergic contact dermatitis. Objectives: To investigate which doses of tetraethylthiuram disulfide (TETD) elicit allergic contact dermatitis by patch testing and in a repeated occluded application test simulating glove use. Patients and Methods: A multicentre study was conducted. Eight patients with contact a
A search for long-lived particles (LLPs) using Formula Presented of Formula Presented collision data with Formula Presented recorded by the ATLAS experiment at the LHC is presented. The search targets LLPs with masses between 5 and 55 GeV that decay hadronically in the ATLAS inner detector. Benchmark models with LLP pair production from exotic decays of the Higgs boson and models featuring long-li
BACKGROUND: Brief Admission by self-referral (BA) was implemented in 2018 in Swedish child and adolescent psychiatric (CAP) inpatient care. This intervention empowers adolescents to self-admit at their own request for brief periods to prevent self-harm and suicidal crisis. As BA enhances healthcare user autonomy, it is a timely intervention to consider with the emerging human rights discourse and
Two 2 x 10-year climate change experiments made with the Rossby Centre regional Atmospheric climate model (RCA) are reported. These two experiments are driven by boundary data from two global climate change simulations, one made with HadCM2 and the other with ECHAM4/OPYC3, in which the global mean warning is virtually the same, 2.6°C. The changes in mean temperature and precipitation show similari
