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Objective: Progressive Supranuclear Palsy (PSP) is a severe neurodegenerative disease characterized by tangles of hyperphosphorylated tau protein and tufted astrocytes. Developing treatments for PSP is challenging due to the lack of disease models reproducing its key pathological features. This study aimed to model sporadic PSP-Richardson's syndrome (PSP-RS) using multi-donor midbrain organoids (M
Purpose: Mental illness due to longstanding stress is increasing. It has been shown that service users with mental illness may benefit from nature-based interventions (NBI), including equine-assisted therapy, to support their health, recovery, and activity level of daily life. However, the evidence base to support this is still weak. The aim was thus to evaluate and provide knowledge of the possib
The moult of Barred Warblers Sylvia nisoria was studied during three winter seasons in southeastern Kenya at a southward passage site (Ngulia) and a wintering site (Mtito Andei). Most Barred Warblers migrating through Ngulia in November had yet to commence winter moult. These birds probably moulted subsequently in winter in northern Tanzania. In December, birds were found in heavy moult at Mtito A
BACKGROUND: One of the critical challenges with capitation payment to primary care providers is ensuring that the fixed payments are equitable and adjusted for expected care needs. Patients of lower socioeconomic status (SES) generally have higher health care need. Sweden developed a Care Needs Index, which is used in the capitation payments to primary care providers to account for patient SES.OBJ
This article presents a critical appraisal of the European Union’s (EU) policy process that delivered the Critical Raw Materials Act, 2023–2024. We combine Marxist-Gramscian perspectives on regional blocs and social movement theory on transnational contestation to study a framing contest at two points in the policy process. First, we examined environmental justice frames in technical campaigns to
PURPOSE: The predictive value of excision repair cross-complementation group 1 (ERCC1) gene for survival and response to platinum-based chemotherapy in gastric cancer (GC) remains controversial. We performed a meta-analysis to clarify the precise estimation of the prognostic and predictive effect of ERCC1.METHODS: A systematic literature search was conducted using PubMed, ScienceDirect, Wiley and
BACKGROUND: Little is known about whether the recommended, non-pharmacological treatments for chronic pain yield reductions in healthcare utilization, social costs and increased productivity in actual practice.METHODS: The primary aim of this study ( n = 232) was to conduct secondary analyses of health economic outcomes using data from national registries combined with clinical outcome data from
Knowledge of animal diets is fundamental in ecology as it can provide insight into the structure, function and resilience of entire ecosystems. In this study we investigate the diet composition of the harbour porpoise (Phocoena phocoena), a small marine top predator with great ecological importance, to provide updated dietary estimates for the species in Swedish waters. This is done by parallel us
Introduction: Patients with substantial comorbidity burden are underrepresented in clinical trials on endovascular thrombectomy (EVT), despite being common in clinical routine care. Therefore, analysis of observational data is needed to evaluate how increasing comorbidity burden affects procedural success rate, complication rate, and clinical outcome following EVT. Patients and methods: We conduct
This article examines how more democratic forms of state-citizen engagement can be engineered under less than favorable political conditions, through the case of the Village Development Committees under the Left Front government in West Bengal, India. Our research shows that these Committees embodied empowered participatory governance ideals and made meaningful contributions to citizens' participa
Background: Non-β-hemolytic streptococci (NBHS) cause blood stream infections (BSI) which can be complicated by infective endocarditis (IE). To stratify the risk for IE in NBHS BSI and to guide the use of echocardiography in this condition, two risk stratification systems (RSSs), the HANDOC score (HANDOC), and the Chamat-Hedemand algorithm (CH-A) have been developed.Objectives: To compare the sens
Title: Women experiencing the second stage of labour for the first time: a qualitative free-text analysis within the Oneplus trial. Background: The second stage of labour is the time from full cervical dilation to the birth of the baby. The risks to the woman and the baby are increased during this stage, leading to intensified midwifery care. A positive birth experience is a significant goal of in
Background: Observational data on composite scores often comes with missing component information. When a complete-case (CC) analysis of composite scores is unbiased, preferable approaches of dealing with missing component information should also be unbiased and provide a more precise estimate. We assessed the performance of several methods compared to CC analysis in estimating the means of common
Purpose: Incisional hernia (IH) after open liver surgery is a well-recognized complication. The clinical importance of IH detected on computed tomography in terms of objective abdominal wall discomfort and impairment of quality of life (QoL) is less well known. Methods: Patients who underwent curative surgery for colorectal liver metastases between 2010 and 2015 at a single center and were alive i
Slow sand filters (SSFs) for drinking water production are habitats for diverse microbes from multiple domains of life, which are integral to the ability of SSFs to purify water. While cultivation-independent analyses of the prokaryotic communities of SSFs have provided valuable insights, little attention has been paid to fungi inhabiting SSFs. This study characterized the fungal communities in th
External quality assessment (EQA) schemes for pathology are essential, yet large/international programmes do not assess morphology-based biomarkers or address local/regional needs. This study outlines bottom-up initiated, flexible Swedish Digital Pathology EQA rounds for breast pathology, and presents results from the 2021 and 2023 rounds. Six breast carcinoma cases were selected for each EQA roun
Background: The growing challenges of population aging create a pressing need for specialized geriatric medicine services to effectively address the complex health needs of older adults and influence supportive healthcare policies. Older patients may present clinical complexity with multimorbidity, disability, and/or frailty, necessitating a shift from the traditional organ-oriented clinical appro
Angiogenesis is a target in the treatment of ovarian cancer. Nintedanib, an oral triple angiokinase inhibitor of VEGF receptor, platelet-derived growth factor receptor, and fibroblast growth factor receptor, has shown activity in phase 2 trials in this setting. We investigated the combination of nintedanib with standard carboplatin and paclitaxel chemotherapy in patients with newly diagnosed advan
Background: Potential fragrance allergens used in daily products should have a concentration limited to levels that are at, or below, acceptable exposure levels based on the quantitative risk assessment for the induction of dermal sensitization. To date, there are insufficient data to discern any quantitative relationship between induction and elicitation concentrations for fragrance ingredients
A search for new heavy particles manifested as resonances in two-jet final states is presented. The data were produced in 7 TeV proton-proton collisions by the LHC and correspond to an integrated luminosity of 315 nb(-1) collected by the ATLAS detector. No resonances were observed. Upper limits were set on the product of cross section and signal acceptance for excited-quark (q*) production as a fu
