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A direct numerical simulation (DNS) coupling with multi-zone chemistry mapping (MZCM) is presented to simulate flame propagation and auto-ignition in premixed fuel/air mixtures. In the MZCM approach, the physical domain is mapped into a low-dimensional phase domain with a few thermodynamic variables as the independent variables. The approach is based on the fractional step method, in which the flo

AZD0837 is a novel oral anticoagulant investigated in clinical studies for stroke prevention in patients with atrial fibrillation (AF). It is bioconverted to its active form, AR-H067637, a potent, specific and reversible thrombin inhibitor.

Developing a functional blood substitute as an alternative to donated blood for clinical use is believed to relieve present and future blood shortages, and to reduce the risks of infection and blood type mismatching. Hemoglobin vesicle (HbV) encapsulates a purified and concentrated human-derived Hb solution in a phospholipid vesicle (liposome). The in vivo safety and efficacy of HbV as a transfusi

We report on theoretical results of magnetic field induced transitions (MITs) in Ne- and Be-like ions without nuclear spin for two applicalions. Firstly, MITs are promising candidates in the determination of magnetic fields in plasmas. In our work on Ne-like ions we present accurate theoretical MIT rates for 2p(6 1)S(O) - 2p(5)3s 3P(O),2 [11. Purthermore, for Be-like ions, it has been proposed to

The use of nucleoside phosphorylases (NPs; EC 2.4.2.n) represents a convenient alternative to the chemical route for the synthesis of natural and modified nucleosides. We purified four recombinantly expressed nucleoside phosphorylases from the bacterial pathogens Citrobacter koseri, Clostridium perfringens, and Streptococcus pyogenes (CkPNPI, CkPNPII, CpUP, SpUP) and their substrate specificity wa

α1-microglobulin (A1M) is a 26 kDa plasma and a tissue protein belonging to the lipocalin family. The reductase and free radical scavenger A1M has been shown to protect cells and extracellular matrix against oxidative and irradiation-induced damage. The reductase activity was previously shown to depend upon an unpaired cysteinyl side-chain, C34, and three lysyl side-chains, K92, 118, and 130, loca

3-Hydroxypropionaldehyde (3HPA), a potential C3-platform chemical for a biobased industry, is produced from glycerol using Lactobacillus reuteri through its glycerol dehydratase activity. However, the process is characterized by low yield and productivity due to toxic effects of 3HPA on the biocatalyst activity. In this study, a semicarbazide-functionalized resin was prepared, evaluated for adsorp

The timing of birth is often correlated with offspring fitness in animals, but experimental studies that disentangle direct effects of parturition date and indirect effects mediated via variation in female traits are rare. In viviparous ectotherms, parturition date is largely driven by female thermal conditions, particularly maternal basking strategies. Our field and laboratory studies of a vivipa

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is usually differentiated based on clinical phenotypes, but recent data indicate that myeloperoxidase (MPO)-AAV is genetically distinct from proteinase 3 (PR3)-AAV. We reviewed a population-based cohort of AAV, focusing on differences in clinical and laboratory characteristics and to compare renal outcome between MPO-ANCA and P

A search is presented for microscopic black holes in a like-sign dimuon final state in proton-proton collisions at root s = 8 TeV. The data were collected with the ATLAS detector at the Large Hadron Collider in 2012 and correspond to an integrated luminosity of 20.3 fb(-1). Using a high track multiplicity requirement, 0.6 +/- 0.2 background events from Standard Model processes are predicted and no

The increasing number of new psychoactive substances made available for recreational drug use has created a challenge for clinical toxicology and drug testing laboratories. As a consequence, the routine immunoassay drug testing may become less effective due to an increased occurrence of false negative and false positive screening results. This work aimed to extend the knowledge about analytical cr

Palaeomagnetic analysis of the Lakhna Dykes (Bastar Craton, India) yields a palaeopole at 36.6 degrees N, 132.8 degrees E, dp=12.4 degrees, dm=15.9 degrees, and the U-Pb zircon age obtained from one of the rhyolitic dykes is 1466.4 +/- 2.6 Ma (MSWD = 0.21, concordia age based on two analyses with identical Pb/U ages), similar to previously published U-Pb ages. Major and trace element analyses of t

Introduction. Manual delineation of the left ventricle is clinical standard for quantification of cardiovascular magnetic resonance images despite being time consuming and observer dependent. Previous automatic methods generally do not account for one major contributor to stroke volume, the long-axis motion. Therefore, the aim of this study was to develop and validate an automatic algorithm for ti

A search for the b (b) over bar decay of the Standard Model Higgs boson is performed with the ATLAS experiment using the full dataset recorded at the LHC in Run 1. The integrated luminosities used are 4.7 and 20.3 fb(-1) from pp collisions at root s = 7 and 8 TeV, respectively. The processes considered are associated (WIZ)H production, where W -> e nu/mu nu, Z -> ee/mu mu, and Z -> nu nu. The obse

An L1 adaptive controller of piecewise constant type has been applied to a fighter aircraft by augmenting it to a linear state-feedback controller. Angle of attack and sideslip as well as velocity vector roll rate is demanded and controlled. It is relatively easy to design a controller augmentation this way; few parameters need to be tuned. To design an L1-controller for roll/pitch/yaw-motion of a