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OBJECTIVES: Under physiological conditions the blood flow velocity waveform in the umbilical vein (UV) has an even non-pulsating pattern. Pulsations in the UV have been described in human fetuses exposed to chronic hypoxia and heart failure. Current techniques for fetal surveillance during labor and delivery involve a risk of both over- and underestimation of fetal hypoxia. We aimed to examine whe
BACKGROUND: Information on autonomic neurapraxia in female urogenital surgery is scarce, and a model to study it is not available. OBJECTIVE: To develop a model to study the impact of autonomic neurapraxia on bladder function in female rats, as well as to assess the effects of corticosteroid therapy on the recovery of bladder function in this model. DESIGN, SETTING, AND PARTICIPANTS: Female Spra
Background: Renal insufficiency is a serious complication of lithium treatment. Therefore, regular monitoring of plasma (P) creatinine is always part of lithium treatment safety routines. Recently P-cystatin C-estimated glomerular filtration rate (cystatin C-eGFR) had been launched as a preferable alternative to P-creatinine. Aims: To find out which of the two alternatives to prefer in the safety
Background: Computed tomography (CT) of the brain is performed with high local doses due to high demands on low contrast resolution. Advanced algorithms for noise reduction might be able to preserve critical image information when reducing radiation dose.PurposeTo evaluate the effect of advanced noise filtering on image quality in brain CT acquired with reduced radiation dose. Material and Method
Mitochondrial dysfunction is an important cause for neonatal liver disease. Disruption of genes encoding oxidative phosphorylation (OXPHOS) components usually causes embryonic lethality, and thus few disease models are available. We developed a mouse model for GRACILE syndrome, a neonatal mitochondrial disease with liver and kidney involvement, caused by a homozygous BCS1L mutation (232A>G). This
This paper describes a driving simulator trial to evaluate driver reactions to a number of alternative information/ warning modes of a multi-modal system for the “safe speed and safe distance” concept. In 2006, eight Human Machine Interaction alternatives, consisting of a combination of visual, haptic and auditory modes were used alternatively to give information/warning to the driver on safe spee
De utsatta bostadsområdena har under årens lopp varit föremål för ett varierande tvärvetenskapligt intresse med inriktning allt ifrån arkitektur, byggteknik och allmänna kommunikationer, till samhällsvetenskapliga studier av bostadspolitikens effekter: befolkningssammansättningar, demokrati, segregation, osv. Forskningsfältet är således i sig mångfasetterat och kan sägas spegla olika perspektiv på
To confirm findings from a previous pilot study in a larger normal cohort and to study first trimester maternal serum levels of cell-free fetal hemoglobin (HbF) and the heme-scavenger α1-microglobulin (A1M) in patients who subsequently developed preeclampsia (PE), furthermore to evaluate these proteins as predictive biochemical markers of PE.
BACKGROUND: Laminin alpha2 chain mutations cause congenital muscular dystrophy with dysmyelination neuropathy (MDC1A). Previously, we demonstrated that laminin alpha1 chain ameliorates the disease in mice. Dystroglycan and integrins are major laminin receptors. Unlike laminin alpha2 chain, alpha1 chain binds the receptors by separate domains; laminin globular (LG) domains 4 and LG1-3, respectively
Aim: To investigate the impact of classical coronary heart disease (CHD) risk factors on the development of future erectile dysfunction (ED). Methods and results: A total of 830 randomly selected subjects were included. Baseline CHD risk factors were evaluated in relation to ED (evaluated by the International Index of Erectile Function-5 questionnaire) 25 years later. At follow-up, 499 men (60%) h
ABSTRACT: BACKGROUND: Today, no objective criteria exist to differentiate between individual primary tumors and intra- or intermammary dissemination respectively, in patients diagnosed with two or more synchronous breast cancers. To elucidate whether these tumors most likely arise through clonal expansion, or whether they represent individual primary tumors is of tumor biological interest and may
Abstract Background. Clinical treatment with radionuclides is usually preceded by biokinetic and dosimetry studies in small animals. Evaluation of the therapeutic efficacy is essential and must rely on accurate dosimetry, which in turn must be based on a realistic geometrical model that properly describes the transport of radiation. It is also important to include the source distribution in the do
To assess parents' opinions about their participation in the longitudinal, multicenter study - The Environmental Determinants of Diabetes in the Young (TEDDY) consortium.
Accurate knowledge about the amount and dynamics of terrestrial gross primary productivity is an important component for understanding of ecosystem functioning and processes. Recently a new diagnostic model, Southampton Carbon Flux (SCARF), was developed to predict terrestrial gross primary productivity at regional to global scale based on a chlorophyll index derived from MERIS data. The model aim
Att kunna cykla ses som närmast självklart i Sverige. Den som inte kan avviker från normen och från föreställningen om vilka kunskaper och kompetenser en vuxen människa förväntas ha. Att inte kunna cykla blir också ett problem för individen som riskerar att begränsas och utestängas. Intresset för cykelkurser är därför stort. I denna rapport om Cykelfrämjandets projekt Frihet på cykel undersöks för
Avsaknaden av en teknisk utbildning på mellannivå framstod i mitten av 1800-talet som såväl ett industrialiserings- som ett moderniseringshinder. Som svar på dessa problem etablerades tekniska elementarskolor under 1850-talet i Malmö, Borås, Örebro och Norrköping. Föreliggande artikel behandlar de viktigaste faktorerna bakom lokaliseringen av dessa skolor och svarar på frågorna varför de förlades
