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Background Open abdomen (OA) treatment often results in difficulties in closing the abdomen. Highest closure rates are seen with the vacuum-assisted wound closure (VAWC) technique. However, we have experienced occasional failures with this technique in cases with severe visceral swelling needing longer treatment periods with open abdomen. Feasibility and short-term outcome of a novel combination o
Extraction systems for hydrophobically tagged proteins have been developed based on phase separation in aqueous solutions of non-ionic detergents and polymers. The systems have earlier only been applied for separation of membrane proteins. Here, we examine the partitioning and purification of the amphiphilic fusion protein endoglucanase I(core)-hydrophobin I (EGI(core)-HFBI) from culture filtrate
Detergent/polymer aqueous two-phase systems are studied as a fast, mild and efficient general separation method for isolation of labile integral membrane proteins. Mechanisms for phase behaviour and protein partitioning of both membrane-bound and hydrophilic proteins have been examined in a large number of detergent/polymer aqueous two-phase systems. Non-ionic detergents such as the Triton series
Activity quantification in nuclear medicine imaging is highly desirable, particularly for dosimetry and biodistribution studies of radiopharmaceuticals. Quantitative In-111 imaging is increasingly important with the current interest in therapy using Y-90 radiolabeled antibodies. One of the major problems in quantification is scatter in the images, which leads to degradation of image quality. The a
The four-year visual outcome was retrospectively studied in patients with older-onset diabetes mellitus and diabetic retinopathy in need of laser treatment. Visual acuity in 53 patients examined by ophthalmologists who referred the patients for an evaluation of retinopathy before laser treatment, was compared to that of 47 patients examined by ophthalmologists who also performed the photocoagulati
OBJECTIVE: To determine the diagnostic value of metaiodobenzylguanidine (MIBG) scintigraphy compared with computed tomography (CT) for the localization of phaeochromocytomas in clinical practice. DESIGN: Retrospective comparison between MIBG scintigrams and CT for localization of phaeochromocytomas in all patients successively examined with MIBG scintigraphy in Malmo from 1984 until January 1997.
Popular Abstract in Swedish Denna avhandling behandlar sociala utredningar om barn. Avhandlingens övergripande syfte är att ur ett kritiskt perspektiv analysera och diskutera hur de rättsligt givna handlingsdirektiven för utredningsförfarandet och det därmed integrerade stöd- och behandlingsarbetet tillämpas i socialtjänstens faktiska utredningsverksamhet, i förhållande till föräldrarna. Frågan bThis thesis is about the social services’ investigations into childrens need of protection and support. The principal purpose is, from a critical perspective, to analyse and discuss how the legally-accorded procedural directives for the execution of an investigation, and therein the integrated support and counselling work, are adapted in the social services’ actual investigation work in relation t
A model has been formulated for the pyrolysis of wood. This model includes heat and mass transfer. Heat transfer in the material is assumed to take place by thermal conduction and convection. Mass transfer of volatile pyrolysis products and water vapour occurs under the influlence of gradients in to tal pressure. Pyrolysis is assumed to conform to an Arrheniusfunction, and vaporization occurs at a
SiGe Esaki diodes have been realized by rapid thermal diffusion of phosphorous into an SiGe layer grown by ultra-high-vacuum chemical-vapor-deposition on an Si p(+)-substrate for the first time. The phosphorous-doped SiGe forms the n(+)-electrode, while heavily boron-doped Si0.74Ge0.26 and Si substrate is used for the p(+) electrode. The diodes show a peak current density of 0.18 kA/cm(2), a curre
Red blood cells may regulate tissue circulation and O-2 delivery by releasing the vasodilator ATP in response to hypoxia. When released extracellularly, ATP is rapidly degraded to ADP in the circulation by ectonucleotidases. In this study, we show that ADP acting on P2Y(13) receptors on red blood cells serves as a negative feedback pathway for the inhibition of ATP release. mRNA of the ADP recepto
Excited states in the T-z-1/2 nucleus Rb-75 were observed for the first time using the Ca-40(Ca-40,alpha p) reaction at 128 MeV. Identification was achieved using events detected by the Daresbury recoil separator in coincidence with gamma rays detected in the 45 element EUROGAM I Ge-detector array. Threefold events were used to build a decay scheme which consists of two rotational bands observed t
A new type of triangular phase diagram has been developed in which both the volume fractions and the shrinkage modes can be visualised and compared for the consolidation process in the paper dryer. The triangular phase diagrams show the development of the solid, the liquid and the gas volume fractions as well as the shrinkage relative to either ideal or no shrinkage of the sheets. Analysis showed
Popular Abstract in Swedish Parkinsons sjukdom uppstår när celler som producerar signalsubstansen dopamin i hjärnan dör. Detta leder till att de drabbade patienterna blir stela, får långsamma rörelser, svårt att påbörja och avsluta rörelser och även skakningar i framförallt armar och händer. Idag finns inget sätt att bota sjukdomen. Dock finns det läkemedel som kan lindra symptomen. Den vanligasteThe main pathological feature in Parkinson's disease is the progressive loss of dopamine neurons in the midbrain, which in turn leads to the appearance of motor deficits such as akinesia/bradykinesia (loss/slowness of movements), rigidity, postural imbalance and tremor. To this day, there is no cure for the disease, but there are medications to relieve the symptoms. The gold standard medication is
OBJECTIVE: To cross-validate, prospectively, the diagnostic performance of established ultrasound methods for discrimination of benign and malignant pelvic masses. METHODS: A total of 173 consecutive women with a pelvic mass judged clinically to be of adnexal origin underwent preoperative ultrasound examination including color and spectral Doppler techniques. A total of 149 tumors were benign, and
Objective: Interstitial laser coagulation (ILC) of the prostate is a minimally invasive method for treating symptomatic benign prostatic enlargement (BPE). We performed a prospective randomized study to compare the clinical outcomes of ILC and transurethral resection of the prostate (TURP). Material and Methods: Between December 1997 and February 2000, 38 patients with moderate-to-severe symptomat
Flow cytometric (FCM) DNA analysis yields information on ploidy status and the S-phase fraction (SPF), variables of prognostic importance in breast cancer. The clinical value of the SPF is currently being evaluated in prospective randomized trials. The widespread use of FCM DNA analysis emphasizes the importance of reproducibility (both intra- and interlaboratory). In this study, 67 nuclear suspen
