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Uronate isomerase (EC 5.3.1.12; URI) catalyzes uronate sugar interconversion, a key step in bacterial metabolism, yet its reaction mechanism remains poorly understood. This study delineates the detailed mechanism for the isomerization of d-glucuronate to d-fructuronate catalyzed by a Zn2+-dependent URI enzyme (from Bacillus halodurans). Using quantum mechanical (QM) cluster calculations, three mec
We present a novel deep neural network architecture for representing robot experiences in an episodic-like memory that facilitates encoding, recalling, and predicting action experiences. Our proposed unsupervised deep episodic memory model as follows: First, encodes observed actions in a latent vector space and, based on this latent encoding, second, infers most similar episodes previously experie
We describe an experimental setup for non-linear interaction and propagation of ultrashort and intense x-ray free-electron laser (XFEL) pulses in a dense gas. It allows one to provide high, but adjustable, target-gas pressures of up to 6 bar within a vacuum environment of 3∙10− 3 mbar or better. The setup enables investigation of intense x-ray propagation in an optically thick medium with minimal
Abstract – Introduction: Peripheral intravenous catheterization is commonly required in sick neonates but remains challenging due to small vessels, leading to multiple attempts and complications. This review evaluated the benefits and harms of device-assisted techniques versus standard technique. Methods: We searched MEDLINE, Embase, CENTRAL, Cochrane Reviews, WHO ICTRP, and ClinicalTrials.gov (Oc
The local average treatment effect (LATE) estimator has enabled a wide range of empirical studies that usenatural experiments to estimate causal effects from observational data. However, this empirical literature has overlooked a crucial assumption regarding the definition of the treatment—thepart of the stable unit treatment value assumption referred to asthe consistency assumption in epidemiolog
Pregnant women have historically and are currently being excluded from cervical cancer screening in most low and middle-income countries (LMICs). The aim of this study was to assess the feasibility and outcomes of including pregnant women in a HPV self-sampling-based screening program in Ethiopia. Pregnant women, recruited from a previously established cohort, were included. They answered a questi
The emergence of antibiotic resistance necessitates effective strategies for evaluating antimicrobial agents. Bioluminescent bacteria, either naturally occurring or engineered with modified reporter genes like bacterial luciferase, provide real-time assessment of bacterial viability through light emission. We investigated the antibacterial effects of cefotaxime and doxycycline using bioluminescent
Currant, and in particular blackcurrant, Ribes nigrum, is widely grown in Europe. It is the host of a number of pest insects, but their occurrence and the damage they cause vary geographically. In northern Europe, three lepidopteran species, the currant shoot borer (Lampronia capitella), the currant clearwing (Synanthedon tipuliformis), and the currant bud moth (Euhyponomeutoides albithoracellus),
When children exercise their right to political participation through climate activism and litigation, they demonstrate that an ethics of care is a core component of the postpaternalist era. Children’s ethics of care, however, is not only about care toward their immediate human relations, but also toward other species, the environment they live in and generations to come. They thereby develop the
Background: Recently developed buprenorphine depot injections have the potential to reduce risk for diversion and misuse, and to increase adherence with fewer visits for supervised intake. However, it is unclear how patients perceive this new form of medication. The purpose of this study was to explore patients experiences of depot injections and their reasons for continuing, discontinuing, or dec
Coherent Diffraction Imaging (CDI) is an experimental technique to image isolated structures by recording the scattered light. The sample density can be recovered from the scattered field through a Fourier Transform operation. However, the phase of the field is lost during the measurement and has to be algorithmically retrieved. Here we present SPRING, an analysis framework tailored to X-ray Free
Background: Geant4, a Monte Carlo Simulation Toolkit extensively used in bio-medical physics, is in continuous evolution to include newest research findings to improve its accuracy and to respond to the evolving needs of a very diverse user community. In 2014, the G4-Med benchmarking system was born from the effort of the Geant4 Medical Simulation Benchmarking Group, to benchmark and monitor the e
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with increased risk of stroke, heart failure, and mortality. One of the systems which AF is influenced by is the autonomic nervous system (ANS), which regulates involuntary functions such as heart rate. Environmental stressors, such as air pollution, may also affect these physiological systems and contribute
Bakgrund: Neuropsykiatriska funktionsnedsättningar uppstår oftast tidigt i barndomen, vilket gör tidig identifiering viktig för att stödja hälsosam utveckling. Det saknas ett bredare screeninginstrument för neuropsykiatrisk funktionsnedsättning för barn under två och ett halvt år. SÖK-Observations instrumentet utvecklades för att identifiera atypisk utveckling och autism hos barn vid 8-månaders hä
Hydrogen-fuelled technologies for home heating and cooking may provide a low-carbon solution for decarbonising parts of the global housing stock. For the transition to transpire, the attitudes and perceptions of consumers must be factored into policy making efforts. However, empirical studies are yet to explore potential levels of consumer heterogeneity regarding domestic hydrogen acceptance. In r
A search for the nonresonant Λc+→pμ+μ- decay is performed using proton-proton collision data recorded at a center-of-mass energy of 13 TeV by the LHCb experiment, corresponding to an integrated luminosity of 5.4 fb-1. No evidence for the decay is found in the dimuon invariant-mass regions where the expected contributions of resonances is subdominant. The upper limit on the branching fraction of th
