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SNP allelic copy number data provides intensity measurements for the two different alleles separately. We present a method that estimates the number of copies of each allele at each SNP position, using a continuous-index hidden Markov model. The method is especially suited for cancer data, since it includes the fraction of normal tissue contamination, often present when studying data from cancer t

The late Eocene may have been a period with an enhanced flux of extraterrestrial matter to Earth related either to a comet or an asteroid shower. The evidence comes from two very large and several medium-sized impact craters, at least two microtektite-microkrystite layers, and a stratigraphic interval with enhanced extraterrestrial He-3, all within the period ca. 36.3-34.3 Ma. Here, we show that t

Popular Abstract in Swedish Avhandlingen analyserar den schweiziske teologen Hans Küng och hans arbete med att utforma en universell moral. Enligt Küng kan världsreligionerna ligga till grund för en moral som kan sträcka sig över alla ideologiska, kulturella och religiösa gränser. Denna moral, som vilar på världsreligionerna, kan sedan ligga till grund för världspolitiken och garantera att relatioThis dissertation analyzes the work on universal morality by the Swiss theologian Hans Küng. According to Küng, a universal morality can be formed out of the world's religions that can reconcile ideological, cultural and religious differences. This morality can then form the basis for international policy and politics and guarantee that relations among states are peaceful. Küng's project focuses

Comparisons have revealed large discrepancies among the many methods for measuring soil CO2 efflux indicating the need for an absolute calibration of methods. This study presents a calibration system, constructed to imitate an area of soil, and its application to two different chamber systems for the measurement Of Soil CO2 efflux: one open and one closed dynamic. Air rich in CO2 was allowed to di

The presence of a specialised dorsal rim area with an ability to detect the e-vector orientation of polarised light is shown for the first time in a nocturnal hymenopteran. The dorsal rim area of the halictid bee Megalopta genalis features a number of characteristic anatomical specialisations including an increased rhabdom diameter and a lack of primary screening pigments. Optically, these special

Several strains belonging to genera Pseudomonas and Achromobacter and characterized by the ability to degrade anionic surfactants were tested as potential bases of microbial biosensors for surfactant detection. For each strain the substrate specificity and stability of sensor signals were studied. The total amount of the substrates tested (including carbohydrates, alcohols, aromatics, organic acid

We report on the applications of a single-longitudinal-mode (SLM) pulsed alexandrite laser system for diagnostics of parameters of flow/combustion interest. The laser system is characterized by its narrow linewidth, high peak power, and broad tunablity. The absolute frequency of the laser output was monitored by a wavelength diagnostic system, which included a high-resolution confocal etalon and a

Analytic expressions for the exact bit error probabilities of rate R = 1/2, memory m = 2 convolutional encoders are derived for a maximum-likelihood (ML) decoder and transmission over the binary-symmetric channel (BSC). The resulting expressions are rational functions of the crossover probability of the BSC. In addition to classical nonsystematic encoders without feedback, we consider also recursi

Combination chemotherapy may induce remission from acute myeloid leukemia (AML), but validated criteria for treatment of elderly are lacking. The remission intention ( RI) rate for elderly patients, as reported to the Swedish Leukemia Registry, was known to be different when comparing the six health care regions, but the consequences of different management are unknown. The Leukemia Registry, cont

Under seeing limited conditions very high resolution spectroscopy becomes very difficult for extremely large telescopes (ELTs). Using adaptive optics (AO) the stellar image size decreases proportional with the telescope diameter. This makes the spectrograph optics and hence its resolution independent of the telescope diameter. However AO for use with ELTs at visible wavelengths require deformable

We tested the hypothesis that populations in small habitat fragments remaining in agricultural landscapes are maintained by repeated immigration, using three grassland butterflies (Aphantopus hyperantus, Coenonympha pamphilus and Maniola jurtina). Transect counts in 12 matched sets of semi-natural pastures, and linear habitat elements proximate and isolated from the pastures showed that population

In a Northern country such as Sweden, energy use in the home may be reduced by 20% through changes in behaviour. However, little is known about how households respond to policy instruments encouraging such change or to what degree this in turn may affect the workload of women and men in such communities. The current study presents findings from interviews with 30 households in Sweden that particip