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Nationwide Observational Case–Control Study of Risk Factors for Aerococcus Bloodstream Infections, Sweden

Risk factors for developing bloodstream infections (BSIs) caused by Aerococcus bacteria remain insufficiently examined. In this nationwide case–control study in Sweden, 19 of 23 clinical microbiological laboratories identified patients who had aerococcal BSIs during 2012–2016. We compared each of those index patients with 4 controls matched for age, sex, and county of residence. Overall, 588 episo

Self-Assembly of Quantum-Confined CsPbBr3 Perovskite Nanocrystals into Rhombic, Frame, and Rectangular Superlattices

Superlattices of quantum-confined perovskite nanocrystals (5–6 nm) present an interesting example of colloidal crystals because of the interplay between nanoscopic parameters (nanocrystal sizes, shapes, and colloidal softness) and the microscopic shapes of their assemblies. These superlattices are reported as rectangular or rhombic, with little discussion of the outcomes of self-assembly experimen

Photophysics and photochemistry of a d5 Ruthenium complex

Transition metal complexes (TMCs) with charge transfer states play a crucial role in photophysical and photochemical processes, particularly in energy conversion applications. This thesis investigates the photophysics and photochemistry of the d⁵ ruthenium complex ([Ru(III)(phtmeimb)2]+), focusing on its excited-state dynamics and charge transfer properties. The photophysical study involves steady

Tuning structure and morphology of lipidic cubosomes by encapsulation of novel porphyrin-derivatives

Cubosomes are non-lamellar lipid nanoparticles that have drawn a significant attention in the field of nanomedicine due to their tunable properties. However, the formation of vesicles during the preparation of cubosomes, and the presence of mixed bicontinuous cubic phases, may lead to artifacts and lack of correlation between the physico-chemical and biological characterization. In this work, we h

ENHANCING DIGITAL TWINS WITH DEEP REINFORCEMENT LEARNING : A USE CASE IN MAINTENANCE PRIORITIZATION

This paper introduces an innovative framework that enhances digital twins with deep reinforcement learning (DRL) to support maintenance in manufacturing systems. Utilizing a sophisticated artificial intelligence (AI) layer, this framework integrates real-time and historical production data from a physical manufacturing system to a digital twin, enabling dynamic simulation and analysis. Maintenance

Common infections in children aged 6 months to 7 years after high prenatal exposure to perfluoroalkyl substances from contaminated drinking water in Ronneby, Sweden

Background: Perfluorinated alkyl substances (PFAS) are suggested to impair immune function in children. Previous studies investigating associations between prenatal PFAS exposure and common infections were performed in background-exposed populations whilst studies from high-exposed populations are lacking. Objectives: To investigate the association between prenatal PFAS exposure from contaminated

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Introduction: Persistent pharmaceutical contaminants, such as Platinum cytostatics, commonly used in cancer therapy, have been detected in water bodies at low concentrations. Electrochemical, photochemical and biological treatments for the removal and degradation of these contaminants are expensive and sometimes ineffective. Sorption methods are a viable and more efficient alternative. Objectives:

Exploring Structural Dynamics and Photophysics in Metal Halide Perovskites and Related Materials

Metal halide perovskites and related materials have sparked intense debate in the field of optoelectronic applications, including solar cells, light-emitting diodes, and lasers. Despite significant progress in improving device efficiency and stability, understanding the structure-property relationships remains largely elusive. This thesis presents an in-depth investigation of the structural dynami

Unraveling the Genetics of Shared Clinical and Serological Manifestations in Patients With Systemic Inflammatory Autoimmune Diseases

OBJECTIVE: Systemic inflammatory autoimmune diseases (SIADs) such as systemic lupus erythematosus (SLE), primary Sjögren disease (pSS), and idiopathic inflammatory myopathies (myositis) are complex conditions characterized by shared circulating autoantibodies and clinical manifestations, including skin rashes, among others. This study was aimed at elucidating the genetics underlying these common f

Importance of individual residues in hydrophobic patch PLVIVGL (1481-1487) in FV-Short for synergistic TFPIα cofactor activity with protein S, an alanine-scanning study: AlphaFold-mediated prediction of FV-Short/TFPIα/protein S trimolecular complex structure

BackgroundIn the splice variant factor (F)V-Short, 702 residues are deleted from the B domain, resulting in exposure of an acid region (AR2; 1493-1537) that binds TFPIα. FV-Short and protein S serve as synergistic TFPIα cofactors in inhibition of FXa. In the preAR2 region, a hydrophobic patch PLVIVGL (1481-1487) is crucial for synergistic TFPIα-cofactor activity and assembly of FV-Short, TFPIα, an

Programmable High-Dimensional Quantum Circuits in Space and Time

We harness the complex mixing process inside a commercial multi-mode fibre to program high-dimensional linear optical circuits for photonic qudits encoded in transverse space and time-of-arrival, and demonstrate their use for high-dimensional entanglement certification.

Fibrinogen genotypes and their impact on recurrence of venous thromboembolism and family history : A prospective population-based study

Venous thromboembolism (VTE) involves blood clot formation in veins, resulting in serious health issues. Fibrinogen, a crucial clotting protein, consists of three polypeptides encoded by the fibrinogen genes: alpha (FGA), beta (FGB) and gamma (FGG). We genotyped most common missense variants in the fibrinogen genes in relation to VTE, recurrence and family history in Malmö Thrombophilia Study, inc

Boosting Membrane Interactions and Antimicrobial Effects of Photocatalytic Titanium Dioxide Nanoparticles by Peptide Coating

Photocatalytic nanoparticles offer antimicrobial effects under illumination due to the formation of reactive oxygen species (ROS), capable of degrading bacterial membranes. ROS may, however, also degrade human cell membranes and trigger toxicity. Since antimicrobial peptides (AMPs) may display excellent selectivity between human cells and bacteria, these may offer opportunities to effectively “tar

Cooling-Induced Order-Disorder Phase Transition in CsPbBr3 Nanocrystal Superlattices

Perovskite nanocrystal superlattices are being actively studied after reports have emerged on collective excitonic properties at cryogenic temperatures, where energetic disorder is minimized due to the frozen lattice vibrations. However, an important issue related to structural disorder of superlattices at low temperatures has received little attention to date. In this work, it is shown that CsPbB

Experimental X-ray Diffraction Data for "Cooling-Induced Order-Disorder Phase Transition in CsPbBr3 Nanocrystal Superlattices"

Experimental X-ray diffraction data: -- temperature-dependent diffraction patterns (theta:2theta, rocking curves) for C18 and C8 CsPbBr3 nanocrystal superlattice samples;-- room temperature diffraction patterns (theta:2theta, rocking curves) for C6, C8, C10, C12, and C18 CsPbBr3 nanocrystal superlattices;in all files, first column is angle in degrees and the second column is intensity.

History of cellular grafting for central nervous system repair—A clinical perspective

As late as in the 1970s, the evidence supporting that brain function might be restored by replacing dead cells by transplantation of new healthy cells was scarce in experimental animals and lacking in humans. Repairing the human brain was regarded as completely unrealistic by clinicians. Fifty years later, the situation is very different, and cellular grafting has reached patient application in se

Health impact assessment of exposure to road traffic noise and air pollution according to pre- and post-densification scenarios in Helsingborg, Sweden

A prevalent solution to accommodate population growth due to urbanization is densification. However, this often pushes new residential housing closer to roads, increasing exposure to both noise and air pollution. The present study's aim was to estimate the health impacts of road traffic-related noise and air pollution for a low-income area (Drottninghög) in Helsingborg, Sweden, according to pre-de

Impact of Exposure to Hand-Held Vibrating Tools on Patient-Reported Outcome Measures after Open Carpal Tunnel Release : A Retrospective Cohort Study with Matched Controls

Objectives: Vibration exposure is a known risk factor for developing carpal tunnel syndrome (CTS), and insufficient outcomes for surgery for CTS have been reported after such exposure. We aim to investigate whether vibration exposure affects patient-reported outcomes following open carpal tunnel release. Methods: From a population surgically treated for CTS (n = 962), we identified patients who re