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Prostate-specific antigen (PSA) levels have been used for detection and surveillance of prostate cancer (PCa). However, factors other than PCa - such as genetics - can impact PSA. Here we present findings from a genome-wide association study (GWAS) of PSA in 28,503 Kaiser Permanente whites and 17,428 men from replication cohorts. We detect 40 genome-wide significant (P<5 × 10-8) single-nucleotide

Aim: Information about the prevalence of special diets in preschool children is limited. The aim of this study was to measure the prevalence of all special diets among preschool children in a Swedish municipality. Methods: This was a population-based cross-sectional survey of all 3276 preschool children aged one to five years in the municipality of Karlskrona, Sweden. The questionnaire assessed th

Kraven på historisk rättvisa har intensifierats under de senaste decennierna. Sanningskommissioner, officiella ursäkter och ekonomiska ersättningar är nu vanliga sätt att bemöta människors vittnesmål om oförrätter i det förflutna. Tidigare forskning har fokuserat på uppgörelser med krig och kolonialism. I denna avhandling studeras gottgörelse för kränkningar i samband med sociala interventioner.I In 1999 the Swedish Parliament decided to provide economic compensation to victims of involuntary sterilization, and in 2012 a similar law was enacted to redress neglect and abuse in foster homes and orphanages. This study explores the dilemmas that arise with reparations for past injustices, focusing on the process leading up to the reparation laws. Four themes are investigated: [1] state redress

INTRODUCTION: Mild haemophilia is a congenital bleeding disorder affecting males. The burden of arthropathy in mild haemophilia has not been comprehensively described.AIM: The aim of this study was to compare the incidence, age at diagnosis and surgery for arthropathy and related hospitalizations between people with mild haemophilia and the general population in Sweden.METHODS: This was a register

This study examines aspects of prediction of suicide and death of undetermined intent. We investigated all consecutive, autopsied patients between 1993 and 1997 who had been in contact with the Addiction Centre in Malmö from 1968 onwards. The staff was asked, shortly after autopsy but before they knew of the manner of death, if they thought the patient had committed suicide. The case records were

Objectives Belimumab is the first biologic drug approved for Systemic Lupus Erythematosus (SLE). Here, we aimed to investigate the effects of belimumab on clinical and serologic outcomes, and sought to identify predictors of treatment response in three Swedish real-life settings. Methods Fifty-eight patients were enrolled at initiation of belimumab and followed longitudinally for up to 53 months.

Aims To assess the incremental value of biomarkers, including N-terminal prohormone of brain natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), growth differentiation factor 15 (GDF-15), and procollagen type 1 N-terminal propeptide (P1NP), in predicting incident cardiovascular events and mortality among asympto

Colony forming or clonogenic assay is an in vitro quantitative technique to examine the capability of a single cell to grow into a large colony through clonal expansion. Clonogenic activity is a sensitive indicator of undifferentiated cancer stem cells. Here, we described the colony forming ability of the isolated breast cancer stem cells from the total population of cancer cells using double-laye

Regeneration of severed peripheral nerves is unfortunately often incomplete, due to loss of nerve fibers and neuroma formation. A new approach is presented with the intention of improving the conditions for nerve repair. In the first of the two stages, a pseudosynovial tube is formed around a silicone rubber rod, surrounded by a stainless steel spiral, which was placed in the backs of rats. This t

I takt med att Sverige strävar efter att uppnå klimatneutralitet har återvinning av schaktmassor fått ökad betydelse. Vikten av samordning mellan olika bygg- och anläggningsprojekt har lyfts för att öka den cirkulära masshanteringen. Lokalt belägna återvinningsanläggningar för massor har angetts som ett sätt att underlätta återvinningen av massor. Samtidigt upplevs lagstiftningen som reglerar olikThe management of excavated materials is becoming more important as Sweden works towards climate neutrality. Improved coordination between construction projects and the use of local recycling facilities are seen as key to enabling circular mass management. However, the legislation governing the establishment and operation of mass recycling facilities is perceived as unclear, particularly regarding

Due to their high reactivity, organolithium and organomagnesium addition to ketones is usually performed under inert atmosphere at low temperature. Recent work has shown that, by dissolving the substrate in deep eutectic solvents (DES), these processes can be carried out on the benchtop, in air at room temperature. Surprisingly, the organometallic reagent, added to the DES from an organic solu

Knowledge about the natural history of severe alpha 1-antitrypsin (AAT) deficiency (PiZZ) is limited. Our aim was to compare the survival of PiZZ individuals with randomly selected controls from the Swedish general population. The PiZZ subjects (n=1585) were selected from the Swedish National AATD Register. The controls (n=5999) were randomly selected from the Swedish population register. Smoking