Filetype
We report two crystal structures of the PARP domain of human tankyrase-2 (TNKS2). Tankyrases are involved in fundamental cellular processes such as telomere homeostasis and Wnt signaling. The complex of TNKS2 with the potent inhibitor XAV939 provides insights into the molecular basis of the strong interaction and suggests routes for further development of tankyrase inhibitors.
Profilins are key regulators of actin dynamics. They sequester actin monomers, forming a pool for rapid polymer formation stimulated by proteins such as formins. Apicomplexan parasites utilize a highly specialized microfilament system for motility and host cell invasion. Their genomes encode only a small number of divergent actin regulators. We present the first crystal structure of an apicomplexa
The gut microbiota plays a crucial role in health and is significantly modulated by human diets. In addition to Western diets which are rich in proteins, high-protein diets are used for specific populations or indications, mainly weight loss. In this study, we investigated the effect of protein supplementation on Bacteroides caccae, a Gram-negative gut symbiont. The supplementation with whey prote
Coherent synchrotron radiation (CSR) is generated when the electron bunch length is in the order of the magnitude of the wavelength of the emitted radiation. The self-interaction of short electron bunches with their own electromagnetic fields changes the longitudinal beam dynamics significantly. Above a certain current threshold, the micro-bunching instability develops, characterized by the appear
Seaweeds (macroalgae) are an attractive resource for diverse microbial- and enzymatic production processes. They are abundant, underutilized, cheap, and rich in carbohydrates, and therefore have the potential to be used as a source of mono- or oligosaccharides, and as substrates for industrial fermentation processes. Many seaweed polysaccharides, including the sulfated polysaccharides ulvan and fu
COVID-19 is a severe respiratory disease affecting millions worldwide, causing significant morbidity and mortality. Adrenomedullin (bio-ADM) is a vasoactive hormone regulating the endothelial barrier and has been associated with COVID-19 mortality and other adverse events. This prospective cohort pilot study included 119 consecutive patients with verified SARS-CoV-2 infection admitted to two inten
In this study, wireless embedded relative humidity, RH, probes, developed by Electrotech Kalix AB, were evaluated in a laboratory setting. These RH-probes are designed to monitor the drying of concrete at construction sites in a Swedish climate. Two concrete slabs, each with a thickness of 100 mm, were fabricated, using two different concrete mixes, with water-to-cement (w/c) ratios of 0.6 and 0.4
The emergence of pandemics like Covid-19 has raised important issues regarding the safe utilisation of spaces due to the potential for virus transmission in both enclosed and open built environments. This chapter explores the challenges posed by pandemics in terms of safe space utilisation, considering the potential virus transmission risks. It presents a risk analysis methodology that makes use o
Collecting detailed hydrogeological data before, during, and after remediation campaigns is essential for effective management and monitoring of contaminated sites. As in-situ remediation injection treatment becomes more popular, recording the hydraulic response during these events offers an opportunity to collect detailed data on hydrogeological parameters. Often, multiple injections are performe
Hur ska vi förstå att det pågår ett folkmord i realtid? Nina Gren hittar vägledning i filosofen Achille Mbembes teori nekropolitik som visar hur social och politisk makt används för att frånta rasifierade människor sitt värde. De blir levande döda.
Shadi Hamid proposes “democratic minimalism” as a system and means of governing and rotating power with no prejudice to substantive ideological outcomes. Democratic minimalism is meant to decouple the question of actualizing an ideal society, even a liberal one that provides maximum freedom for the maximum groups of people, from the mechanism of transferring power between groups with opposing beli
We used infrared reflection microspectroscopy for chemical imaging of urinary calculi and showed that contribution of diffuse reflection, influencing the imaging results, can be suppressed by decreasing surface roughness and (or) increasing wavelength of infrared radiation applied for the imaging.
Introduction: Social robots are accompanied by high expectations of what they can bring to society and in the healthcare sector. So far, promising assumptions have been presented about how and where social robots are most relevant. We know that the industry has used robots for a long time, but what about social uptake outside industry, specifically, in the healthcare sector? This study discusses w
The advances in highly automated and autonomous transportation systems over the last decade have generated great interest in topics in the safe navigation of land vehicles. With distributed control strategies employed in the majority of applications of autonomous vehicles, such as traffic and formation control, the much-required resilience takes the form of fault-tolerance with respect to informat
Early metastatic spread and clonal expansion of individual mutations result in a heterogeneous tumour landscape in metastatic urothelial cancer (mUC). Substantial molecular heterogeneity of common drug targets, such as membranous NECTIN4, FGFR3 mutations, PDL1 or immune phenotypes, has been documented between primary and metastatic tumours. However, translational and clinical studies frequently do
Abstract—In numerous image-based studies, such as cell studies,a plethora of information is embedded in cell objects, whichmust first be accurately extracted before it can be utilized forfurther downstream analysis and linked to biological processesexplored in the original experiment. One such technique forthis purpose is instance segmentation. In our study, whichcell death and associated pathways
Schlieren imaging has been established as a reliable optical measurement technique for flame visualizations and retrieval of laminar burning velocity information. However, it is off limited capability and adaptability due to the optical configuration of a conventional Schlieren setup. In this regard, background oriented Schlieren (BOS) provides a unique opportunity to quantitatively characterize d
Significant groundwater (GW) head decline due to excessive withdrawal is an essential hydrological concern in several major plains of Iran. The capacity of an aquifer to retain GW can be described through the storativity parameters. Traditional methods to define these parameters are costly, time-consuming, and sometimes ineffective. The storativity of an aquifer, irrespective of its confinement ty
