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BACKGROUND: The incidence of colorectal cancer (CRC) in individuals of fertile age is increasing. Oxaliplatin is a cornerstone treatment in the adjuvant setting for stage III and high-risk stage II CRC. Limited data exist on possible side effects of oxaliplatin on fertility and gonadal function. More data is needed to guide possible fertility preservation procedures and aid evidence-based fertilit
Mitotic cells attenuate the DNA damage response (DDR) by phosphorylating 53BP1, a critical DDR mediator, to prevent its localization to damaged chromatin. Timely dephosphorylation of 53BP1 is critical for genome integrity, as premature recruitment of 53BP1 to DNA lesions impairs mitotic fidelity. Protein phosphatase 4 (PP4) dephosphorylates 53BP1 in late mitosis to allow its recruitment to DNA les
This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state-of-the-art protocols for the preparation, phenotype analysis by flow cytometry, generation, fluorescence microscopy, and functional characterization of mouse and human dendritic cells (DC) from lymphoid organs, and various nonlymphoid tissues. Within this article, detailed protocols are prese
PurposeDual design for additive manufacturing (DfAM) takes into account both the opportunities and constraints of AM simultaneously, which research shows is more effective than considering them separately. Unlike existing reviews, this paper aims to map DfAM research within the engineering design process, focusing solely on studies adopting dual DfAM. Additionally, it aims to suggest future resear
Therapies derived from substances of human origin (SoHOs) such as organs, cells, and tissues provide life-saving or life-changing treatment for millions of people worldwide each year. However, many people lack timely access to SoHO-based therapies because of insufficient supplies of these exceptional health resources and/or broader barriers in access to healthcare. Despite well-established governm
Convex maps were first introduced by Hillier and Hanson in "The social logic of space", and have since become a standard diagram of space syntax, particularly in the analysis of interior of buildings. Despite of their extensive use, the computer generation of convex maps turns out to be quite difficult. An algorithmic description of the process would afford an objective form of reproducing analysi
Background: Chronic rhinosinusitis (CRS) disease control is a global metric of disease status for CRS. While there is broad acceptance that it is an important treatment goal, there has been inconsistency in the criteria used to define CRS control. The objective of this study was to identify and develop consensus around essential criteria for assessment of CRS disease control. Methods: Modified Del
We report metallicities for three ∼Gyr-old stars in the Milky Way nuclear star cluster (NSC) using high-resolution near-infrared spectroscopy. We derive effective temperatures from a calibration with Sc line strength, which yields results in good agreement with other methods, and metallicities from spectral fits to Fe i lines. Our derived metallicities range from −1.2 < [Fe/H] < + 0.5, a span of 1
Industry 4.0, with its focus on flexibility and customizability, is pushing in the direction of wireless communication in future smart factories, in particular massive multiple-input multiple-output (MIMO), and its future evolution Large Intelligent Surfaces (LIS), which provide more reliable channel quality than previous technologies. As such, there arises the need to perform efficient scheduling
The increased share of variable renewable energy sources such as wind and solar power poses constraints on the stability of the grid and the security of supply due to the imbalance between electricity production and demand. Chemical storage or power-to-X technologies can provide the flexibility that is needed to overcome this issue. To quantify the needs of such storage systems, energy system opti
We need energy intake to provide energy and nutrients to our cells. The amount of daily energy intake should aim for energy balance, which results in good health. Under-or overconsumption of total daily energy over a longer period leads to increased risk of diseases. In this scoping review, the components of daily energy requirement are defined. Several methods to estimate energy requirements and
To probe into the artistic possibilities of Artificial Intelligence (AI) generating operatic elements, we have engaged in a practice-led inquiry as designers and artists. We took the process of prototyping a chamber opera with interactive features as our starting point, exploring how AI could work as a source of stimuli in opera productions, and how prototyping might add to the design and evaluati
Objectives: The objective of this study was twofold: to determine the prevalence of arterial and venous thromboembolic events in the Norwegian Hereditary Hemorrhagic Telangiectasia (HHT) population, and to explore potential factors linked to such events, with particular emphasis on FVIII. Methods: Patients with an HHT diagnosis attending the Otorhinolaryngology Department at Oslo University Hospit
Robots and autonomous systems are being developed at an ever-increasing rate. Autonomous systems are already prolific in many households around the world, and their adoption is only expected to increase over the coming decades. Even so, many of the systems that are deployed today are still prone to small operational errors such as struggling to navigate complex environments. While the argument ove
Purpose of Review: Despite no general conclusions regarding the therapeutic effect of MSCs on virus-induced acute lung injury in pre-clinical studies, a significant number of clinical trials using MSC-based treatment for COVID-19-associated ARDS were initiated during the global pandemic. Here, we aimed to discuss differences and similarities in clinical trials using MSC-based treatments for classi
In past years efforts have concentrated on the development of arrays of Silicon Drift Detectors for X-ray spectroscopy. This is in stark contrast to the little effort that has been devoted to the improvement of germanium detectors, in particular for synchrotron applications. Germanium detectors have better energy resolution and are more efficient in detecting high energy photons than silicon detec
Titel: Prissättningsproblematiken för multikanalföretag - Hur bemöter multikanalföretag den ökade pristransparensen på Internet Ämne: FEKH69, Examensarbete i redovisning på kandidatnivå, 15 HP Författare: Linn Boman och Emina Holmgren Handledare: Ola Mattisson Nyckelord: Multikanalföretag, marknadsvillkor, ”The Long Tail model” e-handel, prissättningsstrategi, värdebaserad, nischade produkter
CO2 Catalysis has been studied with Planar Laser Induced Fluorescence (PLIF) in combination with a mass spectrometer for a small, 23 cubic centimeters, cube shaped flow reactor. Both catalysis processes with one and with two catalysts inside the reactor have been carried out and analysed. Some results have been visualised by images showing concentration, given by the PLIF signal, of CO2 inside the
