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New therapeutic agents for haemophilia with inhibitors that are in development or already licensed are expected to provide transformative treatment options. Many of these new therapies are not based on simply replacing the missing factor; new strategies include bispecific antibody technology that mimics factor VIII coagulation function (emicizumab), and inhibition of anticoagulant proteins such as
A number of techniques have been proposed to provide runtime performance guarantees while minimizing power consumption. One drawback of existing approaches is that they work only on a fixed set of components (or actuators) that must be specified at design time. If new components become available, these management systems must be redesigned and reimplemented. In this paper, we propose PTRADE, a nov
Background: Body composition is associated with survival outcome in oncological patients, but it is not routinely calculated. Manual segmentation of subcutaneous adipose tissue (SAT) and muscle is time-consuming and therefore limited to a single CT slice. Our goal was to develop an artificial-intelligence (AI)-based method for automated quantification of three-dimensional SAT and muscle volumes fr
Over the last two decades, electrification has gained importance as a means to decarbonise the transport sector. As the number of Electric Vehicles (EVs) increases, it is important to consider broader system aspects as well, especially when deciding the type, coverage, size and location of the charging infrastructure required. This article proposes a new approach using agent-based simulations to a
The use of organic mulch is important for urban green applications. For urban areas in arid and semiarid regions receiving short high-intensive rainfall, rainfall characteristics, and soil slope play an important role for mulch functioning. These properties of mulch were studied. For this purpose, rainfall simulation experiments using organic mulching were conducted in Jiufeng National Forestry Pa
Most waste textiles are currently incinerated or landfilled, which is becoming an increasing environmental problem due to the ever-increasing consumption of textiles in the world. New recycling processes are required to address this problem and, although textile-to-textile recycling would be preferable, many researchers have suggested implementing processes based on the depolymerization of the tex
Musical performance is a multimodal experience, for performers and listeners alike. This paper reports on a pilot study which constitutes the first step toward a comprehensive approach to the experience of music as performed. We aim at bridging the gap between qualitative and quantitative approaches, by combining methods for data collection. The purpose is to build a data corpus containing multimo
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To determine the effects of methylxanthine administration on the incidence of apnea and longer-term clinical outcomes in preterm infants including infants at risk for or having apnea and preterm infants peri-extubation.
Minority shareholdings have been on the regulatory agenda of competition authorities for some time. Recent empirical studies, however, draw attention to a new, thought-provoking theory of harm: common ownership by institutional investors holding small, parallel equity positions in several competing firms within concentrated industries. While critical voices abound, EU and U.S. antitrust agencies c
Syndecan-2 is a heparan sulfate proteoglycan that has a cell adhesion regulatory domain contained within its extracellular core protein. Cell adhesion to the syndecan-2 extracellular domain (S2ED) is β1 integrin dependent; however, syndecan-2 is not an integrin ligand. Here the protein tyrosine phosphatase receptor CD148 is shown to be a key intermediary in cell adhesion to S2ED, with downstream β
Liquid chromatography-mass spectrometry (LC-MS) and mass spectrometry imaging (MSI) are two techniques that are routinely used to study proteins, peptides, and metabolites at a large scale. Thousands of biological compounds can be identified and quantified in a single experiment with LC-MS, but many studies fail to convert this data to a better understanding of disease biology. One of the primary
OBJECTIVES: The National Board of Health and Welfare in Sweden published the national guidelines for Parkinson's Disease 2016. The aim of this study was to summarize this evidence review and development of the guidelines, focusing on the economic evaluation of device-aided therapies (deep brain stimulation, pump-based infusion of levodopa-carbidopa intestinal gel or apomorphine) for Parkinson's di
Svar till flera insändare som varit kritiska på "Min mening" till bekämpningen av vresrosor utmed Helsingborgs kust.
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To determine the effects of systemic opioid analgesics in neonates (term or preterm) undergoing surgery, on mortality, pain and major neurodevelopmental disability, compared to placebo or no drug, non-pharmacological intervention, other opioids, or other analgesics or sedatives.
The aim of this technical note is to present methods that allow for direct computation of the bed roughness due to sediment transport based on a formula developed in the literature for cases involving current or waves separately. The methods result in approximate nondimensional expressions for the exact solutions in terms of polynomials determined by least-square fits, where the accuracy of the po
The generation of attosecond pulse trains at free-electron lasers opens new opportunities in ultrafast science, as it gives access, for the first time, to reproducible, programmable, extreme ultraviolet (XUV) waveforms with high intensity. In this work, we present a detailed analysis of the theoretical model underlying the temporal characterization of the attosecond pulse trains recently generated
Most real-world applications of hypnosis involve a pair of actors: a hypnotist and a subject. Accordingly, most current models of hypnosis acknowledge the relevance of social factors in the development of the hypnotic response. Yet, psychophysiological research on hypnosis has been mostly restricted to techniques that are studying one individual, neglecting the complexity of hypnosis as a social p
Unsatisfactory indoor air quality (IAQ) can result from emissions of volatile organic compounds from the materials of the building. A surface emissions trap (cTrap) can be used to stop such emissions thus preventing them from reaching the indoor air. The present study concerned an apartment where the tenants experienced skin and mucous membrane irritation due to moisture-driven emissions from the
