Search results

Background: Choroid plexus (CP) supports the entry of monocyte-derived macrophages (MDMs) to the central nervous system in animal models of traumatic brain injury, spinal cord injury, and Alzheimer's disease. Whether the CP is involved in the recruitment of MDMs to the injured brain after ischemic stroke is unknown. Methods: Adult male C57BL/6 mice were subjected to focal cortical ischemia by perm

The epidemic of type 2 diabetes mellitus (T2DM) on a global scale is a matter of concern, not only from a public health perspective, but also with consideration of societal costs. The increased call on health care resources to treat and monitor T2DM and its complications could put a heavy burden on national health care systems and financing. An important contributing factor for development of T2DM

III-V compound semiconductors offer a path to continue Moore's law due to their excellent electron transport properties. One major challenge, integrating III-V's on Si, can be addressed by using vapor-liquid-solid grown vertical nanowires. InAs is an attractive material due to its superior mobility, although InAs metal-oxide-semiconductor field-effect transistors (MOSFETs) typically suffer from ba

I takt med att Sverige strävar efter att uppnå klimatneutralitet har återvinning av schaktmassor fått ökad betydelse. Vikten av samordning mellan olika bygg- och anläggningsprojekt har lyfts för att öka den cirkulära masshanteringen. Lokalt belägna återvinningsanläggningar för massor har angetts som ett sätt att underlätta återvinningen av massor. Samtidigt upplevs lagstiftningen som reglerar olikThe management of excavated materials is becoming more important as Sweden works towards climate neutrality. Improved coordination between construction projects and the use of local recycling facilities are seen as key to enabling circular mass management. However, the legislation governing the establishment and operation of mass recycling facilities is perceived as unclear, particularly regarding

Cesium lead bromide (CsPbBr3) perovskite nanocrystals (NCs), with large two-photon absorption (TPA) cross-section and bright photoluminescence (PL), have been demonstrated as stable two-photon-pumped lasing medium. With two-photon excitation, red-shifted PL spectrum and increased PL lifetime is observed compared with one-photon excitation. We have investigated the origin of such difference using t

The project shows that the working environment is rarely the sole cause of early retirement, but working environment factors may explain a large fraction of the transition to disability pension in particular. Several working environment predictors of early retirement are well-documented in the Nordic countries, but workplace policies and activities to retain older workers rarely aim to improve the

Aim: This study assessed whether a Swedish school-based exercise intervention programme could increase total physical activity. Methods: We followed up 228 children who started school in 1998-2000 seven years later, when they had reached a mean age of 14.8. The 152 children (59% boys) at the intervention school did 200 minutes of physical education per week during that period, and the 76 children

AIMS: To investigate subjective health complaints (SHCs) (psychological and somatic, respectively) among disabled and non-disabled adolescents, focusing on the impact of traditional bullying and cyber harassment, and furthermore to report psychological and somatic SHCs across different types of disability.METHODS: Data from the public health survey of children and adolescents in Scania, Sweden, 20

A Scania 13 1 engine modified for single cylinder operations was run using nine fuels in the boiling point range of gasoline, but very different octane number, together with PRF20 and MK1-diesel. The eleven fuels were tested in a load sweep between 5 and 26 bar gross IMEP at 1250 rpm and also at idle (2.5 bar IMEP, 600 rpm). The boost level was proportional to the load while the inlet temperature

The current research focuses in understanding how inlet pressure, EGR, combustion phasing, engine speed and pilot main ratio are affecting the main parameters of the combustion (e.g. efficiency, NOx, soot, maximum pressure rise rate) in the novel concept of injecting high octane number fuels in partially premixed combustion. The influence of the above mentioned parameters was studied by performing

Using alternative fuels like Natural Gas (NG) has shown good potentials on heavy duty engines. Heavy duty NG engines can be operated either lean or stoichiometric diluted with EGR. Extending Dilution limit has been identified as a beneficial strategy for increasing efficiency and decreasing emissions. However dilution limit is limited in these types of engines because of the lower burnings rate of

The behavior of Ethanol and seven fuels in the boiling point range of gasoline but with an Octane Number spanning from 69 to 99 was investigated in Partially Premixed Combustion. A load sweep was performed from 5 to 18 bar gross IMEP at 1300 rpm. The engine used in the experiments was a single cylinder Scania D12. To allow high load operations and achieve sufficient mixing, the compression ratio w

It is tractable to increase the torque for an HCCI engine and one way is to add a turbocharger. Operating in HCCI mode requires accurate control of the combustion phasing, CA50. The higher the engine torque, the narrower the CA50 window becomes where HCCI operation is maintained. As the CA50 varies stochastically between cycles this requires improved CA50 control for turbo HCCI engines. The main f

By using a turbo the operating range of the HCCI engine can be increased, but at the expense of increased controller complexity. The dynamics the turbo introduces in the intake and the exhaust manifolds, have a large impact on the in-cylinder mixture temperature, pressure and finally the combustion phasing. To compensate for this and to maintain desired combustion phasing, precise control of the n

For diesel engines the major exhaust problem is particulate matter and NOx emissions. To reduce NOx, exhaust gas recirculation (EGR) is often used. The behavior of the EGR-level will therefore influence the emissions and it is therefore valuable to keep track of the EGR-level. Especially during transients it is difficult to predict how the EGR-level varies. In this paper the CO2-level in the intak

Partially Premixed Combustion (PPC) is a combustion concept by which it is possible to get low smoke and NOx emissions simultaneously. PPC requires high EGR levels and injection timings sufficiently early or late to extend the ignition delay so that air and fuel mix extensively prior to combustion. This paper investigates the operating region of single injection diesel PPC in a multi cylinder heav

In this study, we present integrated quantitative proteome, transcriptome, and methylome analyses of hematopoietic stem cells (HSCs) and four multipotent progenitor (MPP) populations. From the characterization of more than 6,000 proteins, 27,000 transcripts, and 15,000 differentially methylated regions (DMRs), we identified coordinated changes associated with early differentiation steps. DMRs show

Infections are associated with extensive platelet consumption, representing a high risk for health. However, the mechanism coordinating the rapid regeneration of the platelet pool during such stress conditions remains unclear. Here, we report that the phenotypic hematopoietic stem cell (HSC) compartment contains stem-like megakaryocyte-committed progenitors (SL-MkPs), a cell population that shares