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Antimicrobial peptides (AMPs) are evolutionarily ancient molecules. They are essential innate immune response molecules that protect organisms from invading pathogens. Tissue factor pathway inhibitors (TFPI-1 and TFPI-2) C-terminal derived peptides exert host defense mechanisms against microbes. Studies showed that in human plasma, C-terminal TFPI-1 and -2 derived peptides mediate bacterial killin
Complement C2 deficiency (C2D) is associated with immunological diseases and increased susceptibility to invasive infections caused by encapsulated bacteria such as Neisseria menigitidis. In this study we evaluate the immunogenicity of vaccination against N. menigitidis in C2D. C2D patients (n=22) and controls (n=52) were given a tetravalent meningococcal polysaccharide vaccine. Serum bactericidal
Transplantation of allogeneic embryonic neural tissue is a potential treatment for patients with Parkinson's and Huntington's diseases. The supply of human donor tissue is limited, and alternatives such as the use of animal (e.g., porcine) donor tissue are currently being evaluated. Before porcine grafts can be used clinically, strategies to prevent neural xenograft rejection must be developed. Kn
Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate-specific enzyme human kallikrein-related peptidase 2 (hK2; KLK2). In multiple rodent models, Actinium-225-labeled hu11B6-IgG1 ([225Ac]hu11B6-IgG1) has shown promising treatment efficacy. In the present study, we investigated options to enhance and optimize [225Ac]hu11B6 treatment. First,
It has previously been shown that sera from multiparous women have increased levels of anti-idiotypic antibodies specific for anti-HLA molecules. γ-Globulins prepared from these sera may be superior to commercial preparations of intravenous γ-globulin (IVIg) for inhibiting HLA alloimmunization. To test this, F(ab′)2 fragments prepared from either commercial IVIg or from the sera of men or multipar
Tissue factor pathway inhibitor-2 (TFPI-2) has previously been characterized as an endogenous anticoagulant. TFPI-2 is expressed in the vast majority of cells, mainly secreted into the extracellular matrix. Recently we reported that EDC34, a C-terminal peptide derived from TFPI-2, exerts a broad antimicrobial activity. In the present study, we describe a previously unknown antimicrobial mode of ac
Objective. Antileukoproteinase (ALP) is a physiologic inhibitor of granulocytic serine proteases. The present study was undertaken to investigate its therapeutic benefit in an antibody-transfer model of erosive polyarthritis and to elucidate its potential to interfere with immune complex-dependent inflammatory pathways. Methods. Arthritis development was induced in male (BALB/c x B10.Q)F-1 mice by
Introduction: Recent haemophilia treatment advances include new recombinant FVIII (rFVIII) products with improved pharmacokinetic (PK) properties that aim to reduce the burden of prophylaxis. These treatments are commonly referred to as extended half-life rFVIII products (EHL rFVIII). There is no uniform definition of what constitutes an EHL rFVIII. Such a definition would help physicians, patient
Of 30 bacterial species tested 18 stimulated DNA synthesis in human blood lymphocytes. The maximum response was after 3-4 days of culture suggesting a mitogenic effect. This was confirmed by the induction of polyclonal antibody production shown by a plaque assay. Most bacterial species increased the DNA synthesis in B-enriched lymphocytes and unseparated lymphocytes but had negligible activity on
IgA nephropathy (IgAN) and Henoch-Schönlein purpura (HSP) are diseases characterized by IgA deposits in the kidney and/or skin. Both may arise after upper respiratory tract infections, but the pathogenic mechanisms governing these diseases remain unclear. Patients with IgAN (n = 16) and HSP (n = 17) were included in this study aimed at examining whether IgA-binding M proteins of group A streptococ
Small synthetic ligands for protein purification have become increasingly interesting with the growing need for cheap chromatographic materials for protein purification and especially for the purification of monoclonal antibodies (mAbs). Today, Protein A-based chromatographic resins are the most commonly used capture step in mAb down stream processing; however, the use of Protein A chromatography
Kära medlemmar i Nordic Network for Narratives in Medicine! Vi hoppas att 2023 börjat bra på alla sätt! Här kommer årets första nyhetsbrev och vi passar på att påminna läsarna om att skicka information till mig (Åsa) som ni tror att era med-medlemmar har intresse av. Har ni tankar kring ett möjligt tema för nästa nordiska nätverksmöte (i Trondheim), mejla gärna Katarina.Bernhardsson@litt.lu.se Art
Brevmall 1 Konstnärliga fakulteten i Malmö Disputation och examen inom forskarutbildning Denna guide är framtagen som stöd under disputationsprocessen för doktorander antagna enligt särskild överenskommelse om forskarutbildning mellan Konstnärliga fakulteten, Lunds universitet och - doktorander som antagits inom Konstnärliga forskarskolans (KF) ram, - doktorander i musikpedagogik vid Kungl. Musikh
Master’s Dissertation Structural Mechanics JIMMY PERSSON Report TV SM -5181 JIM M Y PERSSO N N U M ER IC A L A N A LY SIS O F C O M PR ESSIO N PER PEN D IC U LA R TO TH E G R A IN IN G LU LA M B EA M S W ITH A N D W ITH O U T R EIN FO R C EM EN T NUMERICAL ANALYSIS OF COMPRESSION PERPENDICULAR TO THE GRAIN IN GLULAM BEAMS WITH AND WITHOUT REINFORCEMENT Detta är en tom sida! Copyright © 2011 by Str
https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5181.pdf - 2026-05-28
Botaniska trädgården har i samarbete med Visit Lund tagit fram tre olika guidade visningar i trädgården. Dessa kan du gå i egen takt. Du väljer själv om du vill lyssna på turerna eller läsa korta informationstexter. Turerna är följande: Utforska Botan: I denna visning kommer du att få utforska trädgården. Oavsett om du är trädgårdsentusiast eller bara nyfiken att uppleva något vackert, är denna vi
https://www.botan.lu.se/besok-och-program/guidade-visningar-i-appen - 2026-05-29
PowerPoint-presentation Swedish EXPRESS Study Karel Maršál Department of Obstetrics and Gynecology Lund University, Sweden Swedish national prospective study Extremely Preterm Infants in Sweden (EXPRESS) Inclusion criteria: • All live-born infants < 27 gestational weeks • Stillbirths 22+0 – 26+6 weeks April 1, 2004 – March 31, 2007 Exclusion criteria: • Births outside Sweden • Pregnancy terminatio
https://www.epihealth.lu.se/sites/epihealth.lu.se/files/express_cohort_-_epihealth_map_2014_km.pdf - 2026-05-30
