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Genetic factors play an important role in determining bone mass and several genes probably act as regulators of this process. Interleukin-6 (IL-6) is a candidate gene for regulation of bone density, since it has stimulatory effects on cells of the osteoclast lineage and has been implicated in the pathogenesis of bone loss associated with estrogen deficiency. Here we studied the relationship betwee
Nanowires have the ability to absorb light much more efficient than conventional thin film layers. This makes them candidates for the development of new types of solar cells that have higher efficiency and lower material usage than current technologies. In this thesis fabrication of nanowires with techniques suitable for large area applications are investigated. The nanowires are grown by either M
The ability to design and implement silk feedstock formulations for tailored spinning has so far eluded the bioengineers. Recently, the high throughput screening technique of differential scanning fluorimetry (DSF) demonstrated the link between the instability transition temperature (Ti) and the processability of the silk feedstock. Using DSF we screened a large set of chemicals known to affect so
Hydrothermal alteration resulting in albitization and quartz dissolution has been identified in Paleoproterozoic metagranites down to - 1000 m elevation at Forsmark, Sweden. The alteration features were discovered during investigations to locate a site for the disposal of spent nuclear fuel in a deep geological repository. In general, albitization occurs extensively, but it is also observed locall
This paper presents and discusses results from the research project LETS 2050 that studies the governance challenges of a transition to a low-carbon transport and energy system in Sweden by 2050 (www.lets2050.se ). A key starting point of the project was that a low carbon transition is technically possible and economically feasible, while the main challenge is political. At the moment there is an
Abnormal metabolism of β-amyloid (Aβ) and soluble phosphorylated tau (P-tau), as well as neurodegeneration, are key components of Alzheimer disease (AD), but it is unclear how these different processes are related to genetic risk factors for AD.MethodsIn the Swedish BioFINDER study, we tested associations between a priori defined polygenic risk scores (PRSs) for AD (excluding single-nucleotide pol
Gas-liquid displacement in porous media widely exists in many terrestrial/extraterrestrial subsurface resource extraction and utilization applications. The typical fingering displacement during gas invading has been well identified through extensive research efforts. Yet, the evolution of fingering structures after invading breakthrough is rarely reported. Herein, through a joint approach of exper
Light-sheet fluorescent microscopy (LSFM) has, in recent years, allowed for rapid 3D-imaging of cleared biomedical samples at larger and larger scale. However, even in cleared samples, multiple light scattering often degrades the imaging contrast and widens the optical sectioning. Accumulation of scattering intensifies these negative effects as light propagates inside the tissue, which accentuates
Burst-mode laser systems have widely been employed in diagnostics for both reactive and non-reactive flows. Unlike the continuous pulse lasers, burst-mode lasers generate pulses in bursts lasting up to 100 ms, capable to deliver high energies up to Joules per pulse. This high energy fluency is optimal for effective wavelength conversion and tuning, enabling simultaneous measurements of various spe
A method that could assess the whole vehicle non-exhaust particle (NEP) emission from the whole vehicle level was proposed by combining sealed housing with the chassis dynamometer. The intake and exhaust systems were connected to the out of the chamber to avoid possible effects on NEP emissions. The most distinguishing feature of the proposed method is the whole vehicle assessment of the NEP. Base
An essential step for improving climate change models' performance is to evaluate their ability to represent the current climate conditions, especially extreme events. On such background, this study aims at evaluating the performance of the Quantile Delta Mapping (QDM) as a bias correction method for annual maximum daily precipitation series (bmax) generated from downscaled climate change models u
In this paper we conduct a multi-criteria analysis (MCA) from a multiple stakeholder point of view for the design of access and benefit sharing (ABS) agreements concerning genetic resources, in particular regarding the access component of such agreements. We start by analyzing the objectives defined by international law (viz. the Convention on Biodiversity and the Nagoya Protocol) that every party
Human activities in coastal areas have intensified over the last 200 years, impacting also high-latitude regions such as the Baltic Sea. Benthic foraminifera, protists often with calcite shells (tests), are typically well preserved in marine sediments and known to record past bottom-water conditions. Morphological analyses of marine shells acquired by microcomputed tomography (µCT) have made signi
Purpose: The majority of women with ovarian cancer are diagnosed in late stages. Most women do have symptoms prior to diagnosis, sometimes several months before the diagnosis. The aim of this study was to evaluate the timeline from the first presentation of symptoms to a physician until there is a reasonable suspicion of cancer, among women diagnosed with advanced stage ovarian cancer. We wanted t
Autopsy data indicate that the locus coeruleus (LC) is one of the first sites in the brain to accumulate hyperphosphorylated tau pathology, with the rostral part possibly being more vulnerable in the earlier stages of the disease. Taking advantage of recent developments in ultra-high field (7 T) imaging, we investigated whether imaging measures of the LC also reveal a specific anatomic correlation
This study aims at evaluating nutritional, toxicological, and sensory attributes of microwave heat-treated potato powder-supplemented unleavened flatbread. Straight-grade wheat flour (SGF) was substituted with potato powder at the rate of 2.5-10% d.w. A comparison was made for nutritional, antinutrient, and organoleptic attributes of microwave heat-treated potato powder and SGF - potato powder com
Non-technical summaryBrazil – one of the world's largest biocultural diversities – faces high rates of habitat loss, social inequality, and land conflicts impacting indigenous and local peoples. To challenge that, Brazilian sustainability science and education needs to be strengthened. We searched for elements in ongoing bottom-up sustainability social movements that can help serve that purpose. W
Emotion dysregulation and psychological inflexibility are widely regarded as key contributors to a range of mental health issues and are integral to several treatment models in the mental health field. However, no study has examined whether the two constructs reflect distinct aspects of psychological functioning or whether they can be clearly differentiated from mental health symptoms and associat
Inverse stochastic resonance (ISR) is a counterintuitive phenomenon where noise reduces the oscillation frequency of an oscillator to a minimum occurring at an intermediate noise intensity, and sometimes even to the complete absence of oscillations. In neuroscience, ISR was first experimentally verified with cerebellar Purkinje neurons [Buchin et al., PLOS Comput. Biol. 12, e1005000 (2016)]. These
