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Early detection of Alzheimer's disease is essential to develop preventive treatment strategies. Detectible change in brain volume emerges relatively late in the pathogenic progression of disease, but microstructural changes caused by early neuropathology may cause subtle changes in the MR signal, quantifiable using texture analysis. Texture analysis quantifies spatial patterns in an image, such as
This thesis aims at describing the developmental patterns of text production in four text types: spoken and written narrative texts, and spoken and written expository texts (n=316), produced by four age groups: 10-year-olds, 13-year-olds, 17-year-olds and university students (n=79). It explores material from an experimental study with a cross-sectional design comprising spoken texts recorded on vi
I modern svensk myndighetsutövning används tekniska lösningar för att underlätta eller effektivisera interna processer med hjälp av artificiell intelligens (AI). Den offentliga förvaltningen kan nyttja maskininlärda AI-system för beslutsstöd eller till och med automatiserat beslutsfattande. Försäkringskassan använder sådana verktyg för att automatiskt granska vab-ansökningar och markera potentiellIn modern Swedish public administration, technical solutions are used to facilitate or streamline internal processes with the help of artificial intelligence (AI). Public management can use machine-learned systems for assessment purposes or even automated decision-making. The Swedish Social Insurance Agency (Försäkringskassan) uses such tools to automatically review Care of a sick child (vab) appl
Wood is one of the oldest building materials, which have recently gained more focus in aneffort to reach net zero emissions. The mechanical properties of wood are dependent on the moisture content, and a high moisture content can also lead to biological attacks from decay fungi. To avoid biological attacks the wood must be protected from moisture, and a traditional method is to pressure impregnate
Denna rapport avser en stabilitetsanalys för att undersöka möjligheten att bygga en kupol i trä med en spännvidd på 300 meter. Alla lastbärande delar har modellerats med limträ av klassen GL30c och med dimensionerna 0.8×1.6 m2. Lastfallen valdes till 2 kN/m2 respektive 4 kN/m2 för symmetriska och asymmetriska snölaster. De numeriska beräkningarna utfördes i finita element-mjukvaran Abaqus FEA och The aim of this thesis is to study the feasibility of building a timber dome with a span of 300 metres, concerning elastic stability. The load-bearing members were modelled with the properties of glued laminated timber GL30c with the dimensions 0.8×1.6 m2. The design loads were 2 kN/m2 and 4 kN/m2 in symmetrical and asymmetrical load cases, respectively. The numerical calculations were performed u
Ett koordinerat samarbete och tydlig kommunikation utgör grunden för en välfungerande projektering av ett byggprojekt. I det traditionella tillvägagångssättet utförs arbetet sekventiellt, där projektet passerar mellan de inblandade parterna i turordning. Detta linjära arbetsflöde leder ofta till fragmentering av projektdata och svårigheter att bibehålla en gemensam förståelse mellan inblandade parA coordinated collaboration and clear communication forms the foundation for a well-functioning construction project. In the traditional approach, the work is carried out sequentially, where the project is passed on from one involved party to the next. This linear work flow often leads to fragmentation of work data and difficulties in maintaining a common understanding of the project, which in tur
Background and objective: The pharmacokinetics of mycophenolic acid (MPA) are complex, with large interindividual variability over time. There are also well documented interactions with ciclosporin, and assessment of MPA exposure is therefore necessary when reducing or stopping ciclosporin therapy. Here we report on the pharmacokinetic and pharmacodynamic behaviour of MPA in renal transplant patie
Background IKEA has realized the potential benefits of improving inventory management on a strategic level. For IKEA as a market leader in the home furnishing business, an efficient supply chain and proper management of inventory is of crucial importance in order to support their business idea of offering lowpriced products to the many people. Inventory management at IKEA is characterized by an ad
Denna studie presenterar en detaljerad undersökning av utvecklingen av sedimentära landformer under en ablationssäsong vid Blåisen, en del av Hardangerjøkulen, Norge. Två besök vid Blåisen, i början och i slutet av ablationssäsongen, gjorde det möjligt att studera hur landformerna bevaras och utvecklas. Det pågår mycket forskning om glaciala landformer som är en nyckel till förståelse av hur tidigThis study presents a detailed investigation into the evolution of sedimentary landforms over an ablation season at Blåisen, an outlet of the Hardangerjøkulen Icecap, Norway. The two visits to Blåisen, one each side of the ablation season, allowed the preservation and evolution of the landforms to be studied. Much research is conducted studying glacial landforms, which are key in our understanding
Med hänvisning till den rådande resursbristen och till den ökade efterfrågan av vård i allmänhet och intensivvård i synnerhet är prioriteringsbeslut något som många vårdgivare måste befatta sig med dagligen. Under år 2020 när coronapandemin svepte över oss och belastade sjukvården ytterligare så blev frågeställningarna rörande prioriteringsbeslut ännu mer aktuella än innan. Socialstyrelsen släpptIn regard to the current shortage of resources and the increasing demand for care in general and intensive care in particular, priority decisions are something that many healthcare providers have to deal with on a daily basis. In 2020, as the Corona pandemic swept across us and further burdened the healthcare system, the issues surrounding priority decisions became even more relevant than before.
Earlier studies show that different concrete aggregates have different thermal properties, and from this an idea to optimize thermal properties of concrete was developed. The purpose of this master thesis is to investigate thermal properties of concrete so additional costs and negative environmental impacts can be minimized. Measurements of thermal properties of different Swedish aggregates from e
CITED1 as a potential marker of treatment response in breast cancer Background Breast cancer is the most common form of cancer in women worldwide. In the clinic, breast cancer is generally divided into hormone dependent and independent form, based on whether tumor growth is driven by a certain hormone or not. Generally, patients with hormone-dependent breast cancer have a better prognosis compare
This project (Enzymatic degradation of arabinoxylan and phytic acid as a method to increase yield and bioavailability of nutrients in liquid oat base) evaluates the degradation of phytic acid, of the insoluble fraction from Oatly’s existing production process, with the aim of increasing available nutrients such as minerals and proteins. Previous studies have shown that phytic acid from this fracti
Popular science Carbon cycle has great importance in all time scales for its inter-connected relation and response with climate system. Increased anthropogenic emission of CO2 is alleged to impact the climate system in the future, which will affect the feedback between carbon cycle and climate change. In this project, a climate-carbon cycle feedback analysis has been conducted by using long simula
Popular Abstract in Swedish Hormonerna vasopressin och oxytocin frisätts från hypofysens baklob. Hypofysen är en körtel, som är belägen på undersidan av hjärnan och utsöndrar en rad olika hormoner vilka i sin tur påverkar och reglerar aktiviteten i en mängd andra organ. Vasopressin medverkar till regleringen av vatten- och saltbalansen i kroppen, men verkar också sammandragande på icke-viljestyrdVasopressin and oxytocin seem to have pivotal roles in the pathophysiology of primary dysmenorrhoea and preterm labour. Prostaglandins are also involved in the regulation of uterine activity with different receptors mediating both stimulation and relaxation. We explored different aspects of synthesis, release and receptor pharmacology of vasopressin and oxytocin. We also tested a vasopressin and o
Popular Abstract in Swedish Avhandlingen diskuterar den sakramentala kyrkosynen hos den franske, romersk-katolske, teologen Henri de Lubac (1896-1991). Utgångpunkt är hans formulering (i ?Catholicisme? 1938): ?Om Kristus är Guds Sakrament, så är Kyrkan för oss Kristi sakrament. Hon (kyrkan) re-presenterar honom (Kristus), med detta ords hela urgamla kraft: hon gör honom i sanning närvarande.? ForThe thesis provides a discussion of the ecclesiology of the French Roman-Catholic theologian Henri de Lubac SJ (1896-1991) by showing how this is determined by his method of fundamental theology. I establish the term ?fundamental ecclesiology? for this inter-dependance of form and content, subject and object in theology; this is why his ecclesiology is sacramental in structure. I primarily use tex
As current silicon-based microelectronic devices and circuits are approaching their fundamental limits, the research field of nanoelectronics is emerging worldwide. With this background, the present thesis focuses on semiconductor nanoelectronic devices based on ballistic and quantum effects.
The main material studied was a modulation doped In0.75Ga0.25As/InP semiconductor two-dimensional el
Popular Abstract in Swedish Helicobacter pylori är en spiralformad Gramnegativ human-specifik patogen, som kan penetrera magsäckens slemlager och kolonisera epitelskiktet. H. pylori infektion är en högriskfaktor för utvecklandet av kronisk gastrit, magsår och ventrikelcancer. Både aktivt växande spiralformer av H. pylori och dess runda viloformer framkallar kronisk magkatarr (gastrit) i BALB/cA möHelicobacter pylori is a human pathogen strongly associated with chronic type B gastritis, peptic ulcer disease, gastric cancer and MALT lymphoma. Our aims were to establish a mouse model of H. pylori infection, to study pathogenesis of gastritis and gastric cancer and to investigate new treatment strategies in this model. Both spiral and coccoid forms of H. pylori strains 17874, 25 and 553/93 cau
Cloud computing has quickly grown to become an essential component in many modern-day software applications. It allows consumers, such as a provider of some web service, to quickly and on demand obtain the necessary computational resources to run their applications. It is desirable for these service providers to keep the running cost of their cloud application low while adhering to various perform
Bergskedjor är uppbyggda av olika slags berggrund som skjutits samman i de zoner på Jorden där tektoniska plattor möts (konvergerar). Sådana processer sker i dag exempelvis i Himalaya, Alperna eller Anderna, men det finns också gamla, nu inaktiva, bergskedjor som de Skandinaviska Kaledoniderna (ca 400 miljoner år gammal) eller den Svekonorvegiska bergskedjan (ca 1000 miljoner år gammal, i sydvästrThe 1.1-0.9 Ga Sveconorwegian orogen is one of several Grenvillian-aged orogenic belts that mark the amalgamation of supercontinent Rodinia. The highest-pressure rocks in the Sveconorwegian orogen are eclogites in the Eastern Segment (SW Sweden). The eclogites occur in a nappe in the high-grade metamorphic level of the Eastern Segment that represents a window into the deepest part of this Precambr
