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Abstract Over the past decade, mass spectrometry has had an essential role in improvement of proteomics techniques. New instrument and analytical protocol developments have made mass spectrometry one of the most widely used analytical methods in quantitative proteomics. Today one of the commonly used protocols in proteomics is digestion of proteins to peptides and analysis of the peptides with li
Popular Abstract in Swedish Det försurande nedfallet över Europa har minskat kraftigt sedan 1970- och 1980-talen. Detta beror delvis på framgångsrikt arbete inom konventionen om långväga gränsöverskridande luftföroreningar (LRTAP), inom ramen för FN:s ekonomiska kommission för Europa (UNECE). Marken i många områden i Sverige och övriga Europa är fortfarande kraftigt försurad trots det minskade ned
The aims of this study have been focused on the identification of cell surface structures involved in the induction and regulation of apoptosis. Monoclonal antibodies against the major histocompatibility complex class I (MHC-I) were shown to induce apoptosis when cross-linked on the cell surface of different malignant cells having a pre-B or a myeloid precursor phenotype. The apoptotic response wa
Popular Abstract in Swedish Genom att inta en bärdryck med extra fiber från råg eller havre steg inte blodsockret och insulinnivån lika snabbt jämfört med samma måltid utan fiber i drycken. Dessutom visade ett test två timmar efter havreklimåltiden att avläsningen av insulinrelaterade gener (genuttrycket) hade nedreglerats. Andra gener som påverkades av havremåltiden var kopplade till proteinsynteIt is well established that dietary fibre, especially soluble dietary fibre, has beneficial effects and can prevent diseases associated with the modern lifestyle. This has been explained by the viscous effects of soluble fibre, which can reduce or delay the absorption of carbohydrates and fat in the small intestine, resulting in lower blood concentrations of glucose, insulin and cholesterol. Oats,
Popular Abstract in Swedish Datorer har blivit en viktig del inom den moderna medicinen. Resultat från patientundersökningar såsom bilder, kurvor och mätvärden bearbetas ofta av datorer och presenteras sedan på ett överskådligt sätt för läkaren som grundar sitt svar på bland annat denna information. Denna doktorsavhandling beskriver hur datorn kan hjälpa till vid själva tolkningen av undersökningThe principal purposes of the studies reported in this thesis were to develop new methods to make computerised decision support systems in medicine both more reliable and fully automated. These aims were pursued in the belief that the solution to these problems will lead to an increased clinical use of such systems resulting in benefit to both patient and physician. In the first two studies, meth
Popular Abstract in Swedish Är det möjligt att det pågår en hård kamp under våra fötter när vi tar en promenad i den Skånska lövskogen? Oftast tänker man på ett positivt förhållande mellan växter och marken's bakterier och svampar, där den autotrofa växten omvandlar luften's kol (C), i form av koldioxid, till organiskt C som därigenom blir tillgängligt för mikroorganismerna. Mikroorganismerna bryCompetition between and within species has been one of the most studied concepts in ecology. In this thesis the aim was to test the idea of plant-microbial competition for N and, by studying this interaction, to gain a better understanding of different N processes in soil. The research carried out seeks to investigate plant-microbial competition for N based on the definition that competition only
In this chapter a technology for the enhancement of video data obtained at low light levels is presented. The method was inspired by the way in which nocturnal animals adaptively sum intensities, spatially and temporally, to improve vision at night. Due to the low photon count under these conditions the visual input is dark and unreliable, which leads to noisy low contrast images. The noise become
α-Synuclein (aSyn) is a 140 residue long protein present in presynaptic termini of nerve cells. The protein is associated with Parkinson's disease, in which case it has been found to self-Assemble into long amyloid fibrils forming intracellular inclusions that are also rich in lipids. Furthermore, its synaptic function is proposed to involve interaction with lipid membranes, and hence, it is of in
Natural selection on floral scent composition is a key element of the hypothesis that pollinators and other floral visitors drive scent evolution. The measure of such selection is complicated by the high-dimensional nature of floral scent data and uncertainty about the cognitive processes involved in scent-mediated communication. We use dimension reduction through reduced-rank regression to jointl
The streaming instability is a promising mechanism to induce the formation of planetesimals. Nonetheless, this process has been found in previous studies to require either a dust-to-gas surface density ratio or a dust size that is enhanced compared to observed values. Employing two-dimensional global simulations of protoplanetary disks, we show that the vertical shear instability and the streaming
Industrialization and the emergence of a manufacturing sector are generally perceived as key drivers for countries to see economic growth and increases in living standards. Only 200 years ago, most countries were relatively poor and had similarly low living standards. With industrialization and the growth of manufacturing, primarily Western countries pulled ahead and noticed sustained increases in
Seaweeds (macroalgae) are gaining attention as potential sustainable feedstock for the production of fuels and chemicals. This comparative study focuses on the characterization of the microbial production of alcohols from fermentable carbohydrates in the hydrolysate of the macroalgae Laminaria digitata as raw material. The potential of a hydrolysate as a carbon source for the production of selecte
An increasing number of researchers record binocular eye-tracking signals from participants viewing moving stimuli, but the majority of event-detection algorithms are monocular and do not consider smooth pursuit movements. The purposes of the present study are to develop an algorithm that discriminates between fixations and smooth pursuit movements in binocular eye-tracking signals and to evaluate
When trying to map the bibliometrics based ‘research evaluation landscape’ in terms of for instance methods, technical systems and stakeholders; the complexities soon become obvious. Different methods are used at different national and local levels; there is a great variation of systems used for gathering, organizing, and analyzing data; and a multitude of stakeholders, many of which taking on a v
BACKGROUND: Thrombosis is one of the most important causes of morbidity in the medical field. Several independent in vitro studies have shown that the fibrinolytic process may be enhanced by ultrasound, but the effect of ultrasound on thrombus formation in vivo is unexplored. The present study was designed to investigate this matter. METHODS: In a blind randomized study, standardized arteriotomies
The prediction of transcription factor binding sites in genomic sequences is in principle very useful to identify upstream regulatory factors. However, when applying this concept to genomes of multicellular organisms such as mammals, one has to deal with a large number of false positive predictions since many transcription factor genes are only expressed in specific tissues or cell types. We devel
Angiogenesis and increased permeability of the blood-brain barrier have been reported to occur in animal models of Parkinson's disease and l-dopa-induced dyskinesia, but the significance of these phenomena has remained unclear. Using a validated rat model of l-dopa-induced dyskinesia, this study demonstrates that chronic treatment with l-dopa dose dependently induces the expression of vascular end
Background: Ischemic injury to the pancreas occurs in various clinical conditions. A method for online monitoring of pathophysiological events in pancreatic parenchyma is missing. Aims: To assess the timing of microdialysis (MD) technique response on temporary changes in pancreatic perfusion, and to evaluate the relationship between MD data and systemic markers of anaerobic metabolism and inflamma
1. When stimulating the local nerves in the bovine ovarian follicle wall preparation (4 Hz, 1 ms pulse duration and 7.5 V between the electrodes) vasoactive intestinal polypeptide reduced the neurogenic contraction and at the highest concentration tested (3 x 10(-7) M) almost abolished the response. Peptide histidine isoleucine only slightly reduced the contraction. 2. Strips from the follicle wal
